Reduced Side Effects following Administration of a New Anorectic Agent, 4′-Chloro-2-(ethylamino)propiophenone, in Timed-Release Form

Rosen, Earl; Free, Spencer M.; Heil, George C.

doi:10.1002/jps.2600601236

Cited by 3 publications

(1 citation statement)

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“…This led to the conclusion that it is the metabolite, and not the starting diethylpropion, that causes the specific anorectic effect [7]. Compound 2 (4-chloroethcathinone, 4-CEC) had been briefly studied in terms of its potential anorectic effect [8]. Its current availability on the illegal drug market makes it probable that this compound will be taken off the register of medical drug candidates.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic characterization and crystal structures of two cathinone derivatives: N-ethyl-2-amino-1-phenylpropan-1-one (ethcathinone) hydrochloride and N-ethyl-2-amino-1-(4-chlorophenyl)propan-1-one (4-CEC) hydrochloride

et al. 2016

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Comprehensive chemical characterization for two cathinone derivatives, N-ethyl-2-amino-1-phenylpropan-1-one (ethcathinone) hydrochloride and N-ethyl-2-amino-1-(4-chlorophenyl)-propan-1-one (4-chloroethcathinone, 4-CEC) hydrochloride, in material seized by drug enforcement agencies was performed by nuclear magnetic resonance (NMR) spectroscopy, infrared spectroscopy, gas chromatography–mass spectrometry in positive electron ionization mode, liquid chromatography–mass spectrometry in positive electrospray ionization mode and X-ray crystallography. The examined samples of these two compounds proved to be very pure for ethcathinone and mixed with very small quantities of other substances for 4-CEC by NMR spectroscopy and mass spectrometry. X-ray crystallographic studies confirmed the occurrence of both compounds as racemic mixtures. These spectroscopic and crystallographic data seem very useful for their identification. Especially for 4-CEC, this is the first description on its spectroscopic characterization in a scientific context to our knowledge.

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Section: Introductionmentioning

confidence: 99%