Reduced sialyl-Lewis^xon salivary MUC7 from patients with burning mouth syndrome

Abstract

We analyse and compare MUC7 O-glycosylation and inflammatory biomarkers in saliva from female patients with burning mouth syndrome (BMS) and gender/age-matched controls.

Salivary and Serum Inflammatory Profiles Reflect Different Aspects of Inflammatory Bowel Disease Activity

“…The majority of the inflammatory proteins, 67 out of 92, were detected in serum and in unstimulated and stimulated saliva samples, which is the highest detection rate of the Olink inflammation panel in saliva to date. 23 , 24 This result supports the hypothesis that salivary proteins may be analogous to circulatory biomarkers, since approximately 40% of previously suggested disease markers in plasma are detected in saliva as well. 25 Yet distinct differences in protein expression patterns were observed between serum and saliva, and the correlation of protein expression between saliva and serum was scarce.…”

Salivary biomarkers in burning mouth syndrome: A systematic review and meta‐analysis

“…This resulted in 33 possible references. After reading the full‐text articles, 16 references were discarded for the following reasons: one for not having a CG (Kang et al, 2017), one for not analyzing biomarkers (Castillo‐Felipe et al, 2021), two for being letters to the editor (Boras et al, 2006; López‐Jornet et al, 2009), four for evaluating genetic polymorphisms (Campello et al, 2020; Guimarães et al, 2006; Kim et al, 2017; Vucićević‐Boras et al, 2003), five for not clarifying the diagnostic criteria used for BMS (Hershkovich & Nagler, 2004; Loeb et al, 2008; Simcić et al, 2006; Srinivasan et al, 2008; Suh et al, 2009), and three for not presenting numerical values for biomarker levels (Acharya et al, 2019; Ji et al, 2017; Kho et al, 2013; these values were requested from the authors, and no response was obtained). Finally, 17 studies were included in this systematic review (Figure 1).…”

“…The International Classification of Orofacial Pain (ICOP) defines burning mouth syndrome (BMS) as “an intraoral burning or dysaesthetic sensation, recurring daily for more than 2 h/day for more than 3 months, without evident causative lesions on clinical examination and investigation” (ICOP, 2020). BMS affects 4% of the general population and 18%–33% of all postmenopausal women (Acharya et al, 2019; Ji et al, 2017; Lopez‐Jornet et al, 2020; Pekiner et al, 2009). BMS patients suffer bilateral intraoral pain or burning sensation that can vary in intensity without obvious clinical changes.…”

“…BMS patients suffer bilateral intraoral pain or burning sensation that can vary in intensity without obvious clinical changes. The most frequent location of the pain is the tip of the tongue, but it can also affect palate and lips (Acharya et al, 2019; Campello et al, 2020; Dias Fernandes et al, 2009; Ji et al, 2017; Lopez‐Jornet et al, 2020; Pekiner et al, 2009; Simcić et al, 2006). Pain is often accompanied by xerostomia (without hyposalivation), dysesthesia, and taste alterations (Acharya et al, 2019; Campello et al, 2020; Dias Fernandes et al, 2009; Imura et al, 2016; Ji et al, 2017; Lončar‐Brzak et al, 2020; Pekiner et al, 2009; Simcić et al, 2006).…”

Is Burning Mouth Syndrome Associated with Extraoral Dryness? A Systematic Review

“…The same group of researchers also analyzed the salivary samples of BMS patients and controls and demonstrated a complex pattern of inflammatory biomarkers, including Cystatin-5, (CST-5), Interleukin-7 (IL-7), Fibroblast Growth Factor-19 (FGF- 19), and C-C Motif Chemokine 19 . Both higher and lower levels of biomarkers were found in the BMS patients compared with the controls, indicating that BMS patients represent a diverse group when considering their levels of inflammatory biomarkers [27]. Although this study provided valuable insights, the concept of extraoral dryness, potential reasons, consequences for patients, and potential strategies to prevent or treat it remain uninvestigated.…”