Reduced Short-Latency Afferent Inhibition in Prefrontal but not Motor Cortex and Its Association With Executive Function in Schizophrenia: A Combined TMS-EEG Study

Noda, Yoshihiro; Barr, Mera S.; Zomorrodi, Reza; Cash, Robin; Rajji, Tarek K.; Farzan, Faranak; Chen, Robert; George, Tony P.; Daskalakis, Zafiris J.; Blumberger, Daniel M.

doi:10.1093/schbul/sbx041

Cited by 31 publications

(51 citation statements)

References 56 publications

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“…Studies have reported N100 to be associated with GABA B -mediated inhibitory mechanisms in both motor (Bonnard et al, 2009;Farzan et al, 2013;Premoli, Rivolta, et al, 2014b;Rogasch, Daskalakis, et al, 2013a) and prefrontal cortex (Chung et al, 2017;Rogasch et al, 2015). The amplitude of N100 increased following SAI both in motor and prefrontal cortex (Noda et al, 2016;Noda, Zomorrodi, Backhouse, et al, 2017c), but decreased following cerebellar iTBS (Casula, Pellicciari, Ponzo, et al, 2016b), which are in line with the change observed in N100 following Ind iTBS. However, our previous studies showed increased N100 following prefrontal iTBS (50 Hz at 5 Hz) (Chung et al, 2017;Chung, Rogasch, Hoy, & Fitzgerald, 2018a;Chung, Rogasch, Hoy, Sullivan, et al, 2018b), and the discrepancy of the outcome…”

Section: Effect Of Individualised Itbs On Plastic Effects In the Prsupporting

confidence: 74%

“…The N100 is regarded as the most robust component in TMS-EEG recordings (Noda et al, 2016) with excellent reproducibility (Lioumis, Kicic, Savolainen, Makela, & Kahkonen, 2009) and signal to noise ratio (Chung et al, 2017). In addition, the N100 deflection is considered to have a high sensitivity to small changes in cortical excitability compared with other TEPs (Nikulin, Kicic, Kahkonen, & Ilmoniemi, 2003), making it an ideal candidate for tracking neuromodulatory paradigms.…”

Section: Effect Of Individualised Itbs On Plastic Effects In the Prmentioning

confidence: 99%

“…Characterisation of P200 is needed to better understand its role, as the changes in this component are often observed following neuromodulation (Casula, Pellicciari, Ponzo, et al, 2016b;Chung et al, 2017;Noda et al, 2016) or in clinical populations (Noda, Barr, Zomorrodi, Cash, Rajji, et al, 2017b). Positive correlations were observed only between mood and neurophysiological measures that showed the greatest change (i.e., Δ P60 at T5, Δ N100 at T30), suggesting robust physiological changes are required to translate into a behavioural outcome.…”

Section: Relationship Between Neurophysiological Changes and The Chmentioning

confidence: 99%

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The effects of individualised intermittent theta burst stimulation in the prefrontal cortex: A TMS‐EEG study

Chung

Sullivan

Rogasch

et al. 2018

Human Brain Mapping

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Recent studies have highlighted variability in response to theta burst stimulation (TBS) in humans. TBS paradigm was originally developed in rodents to mimic gamma bursts coupled with theta rhythms, and was shown to elicit long‐term potentiation. The protocol was subsequently adapted for humans using standardised frequencies of stimulation. However, each individual has different rhythmic firing pattern. The present study sought to explore whether individualised intermittent TBS (Ind iTBS) could outperform the effects of two other iTBS variants. Twenty healthy volunteers received iTBS over left prefrontal cortex using 30 Hz at 6 Hz, 50 Hz at 5 Hz, or individualised frequency in separate sessions. Ind iTBS was determined using theta‐gamma coupling during the 3‐back task. Concurrent use of transcranial magnetic stimulation and electroencephalography (TMS‐EEG) was used to track changes in cortical plasticity. We also utilised mood ratings using a visual analogue scale and assessed working memory via the 3‐back task before and after stimulation. No group‐level effect was observed following either 30 or 50 Hz iTBS in TMS‐EEG. Ind iTBS significantly increased the amplitude of the TMS‐evoked P60, and decreased N100 and P200 amplitudes. A significant positive correlation between neurophysiological change and change in mood rating was also observed. Improved accuracy in the 3‐back task was observed following both 50 Hz and Ind iTBS conditions. These findings highlight the critical importance of frequency in the parameter space of iTBS. Tailored stimulation parameters appear more efficacious than standard paradigms in neurophysiological and mood changes. This novel approach presents a promising option and benefits may extend to clinical applications.

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Section: Effect Of Individualised Itbs On Plastic Effects In the Prsupporting

confidence: 74%

Section: Effect Of Individualised Itbs On Plastic Effects In the Prmentioning

confidence: 99%

Section: Relationship Between Neurophysiological Changes and The Chmentioning

confidence: 99%

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The effects of individualised intermittent theta burst stimulation in the prefrontal cortex: A TMS‐EEG study

Chung

Sullivan

Rogasch

et al. 2018

Human Brain Mapping

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“…A recent meta‐analysis of the working memory performance following noninvasive brain stimulation demonstrates only small effect sizes in improvement in healthy controls compared to clinical populations that showed medium effect sizes (Brunoni & Vanderhasselt, ). Greater behavioural effects may be detected in disorders of WM, such as schizophrenia, in which considerable differences in physiological measures are often observed compared to a control group (Ferrarelli et al, ; Noda et al, ). However, it is also conceivable that other cognitive tasks may provide more robust behavioural outcome and should further be investigated.…”

Section: Discussionmentioning

confidence: 99%

Impact of different intensities of intermittent theta burst stimulation on the cortical properties during TMS‐EEG and working memory performance

Chung

Rogasch

Hoy

et al. 2017

Human Brain Mapping

100

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Intermittent theta burst stimulation (iTBS) is a noninvasive brain stimulation technique capable of increasing cortical excitability beyond the stimulation period. Due to the rapid induction of modulatory effects, prefrontal application of iTBS is gaining popularity as a therapeutic tool for psychiatric disorders such as depression. In an attempt to increase efficacy, higher than conventional intensities are currently being applied. The assumption that this increases neuromodulatory may be mechanistically false for iTBS. This study examined the influence of intensity on the neurophysiological and behavioural effects of iTBS in the prefrontal cortex. Sixteen healthy participants received iTBS over prefrontal cortex at either 50, 75 or 100% resting motor threshold in separate sessions. Single-pulse TMS and concurrent electroencephalography (EEG) was used to assess changes in cortical reactivity measured as TMS-evoked potentials and oscillations. The n-back task was used to assess changes in working memory performance. The data can be summarised as an inverse U-shape relationship between intensity and iTBS plastic effects, where 75% iTBS yielded the largest neurophysiological changes. Improvement in reaction time in the 3-back task was supported by the change in alpha power, however, comparison between conditions revealed no significant differences. The assumption that higher intensity results in greater neuromodulatory effects may be false, at least in healthy individuals, and should be carefully considered for clinical populations. Neurophysiological changes associated with working memory following iTBS suggest functional relevance. However, the effects of different intensities on behavioural performance remain elusive in the present healthy sample.

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“…In another study by the same group, cholinergic activity was assessed in SCZ via a recently developed TMS‐EEG paradigm, i.e., short‐latency afferent inhibition (SAI). In this study, SAI was investigated in 12 individuals with SCZ compared with 12 age‐matched healthy controls . Results showed impaired SAI in the DLPFC, but not in the control region, in patients with SCZ.…”

Section: Schizophreniamentioning

confidence: 97%

The Current and Future Potential of Transcranial Magnetic Stimulation With Electroencephalography in Psychiatry

Hui

Tremblay

Daskalakis

2019

Clin Pharma and Therapeutics

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The search for biological targets in psychiatric disorders is essential to better understand illness mechanisms and also to monitor and predict response to currently available therapeutic interventions. To this end, the combination of transcranial magnetic stimulation with electroencephalography (TMS‐EEG) has emerged as a powerful clinical research tool. TMS‐EEG allows cortical properties, such as excitability, inhibition, oscillatory activity, and connectivity, to be directly probed within a specific region of the cortex. This review will summarize the state of the current literature on TMS‐EEG and its potential to uncover biological targets in psychiatric illnesses, with a focus on major depressive disorder, bipolar disorder, and schizophrenia. Collectively, the reviewed studies suggest that alterations in gamma‐aminobutyric acid‐mediated inhibition and gamma oscillations in the dorsolateral prefrontal cortex and neighboring frontal regions are potential shared biomarkers in psychiatry, highlighting the potential of TMS‐EEG to help identify translational biomarkers.

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Reduced Short-Latency Afferent Inhibition in Prefrontal but not Motor Cortex and Its Association With Executive Function in Schizophrenia: A Combined TMS-EEG Study

Abstract: Our findings suggest that DLPFC-SAI but not M1-SAI were reduced in patients with schizophrenia and this was linked to deficits in cognition. This may reflect prefrontal cholinergic deficits and represent a biomarker for cholinergic and executive dysfunction in patients with schizophrenia.

Cited by 31 publications

References 56 publications

The effects of individualised intermittent theta burst stimulation in the prefrontal cortex: A TMS‐EEG study

The effects of individualised intermittent theta burst stimulation in the prefrontal cortex: A TMS‐EEG study

Impact of different intensities of intermittent theta burst stimulation on the cortical properties during TMS‐EEG and working memory performance

The Current and Future Potential of Transcranial Magnetic Stimulation With Electroencephalography in Psychiatry

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