Reduced Serum IGF-1 Associated With Hepatic Osteodystrophy Is a Main Determinant of Low Cortical but Not Trabecular Bone Mass

Liu, Zhongbo; Han, Tianzhen; Werner, Haim; Rosen, Clifford J.; Schaffler, Mitchell B.; Yakar, Shoshana

doi:10.1002/jbmr.3290

Cited by 20 publications

(18 citation statements)

References 89 publications

(175 reference statements)

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“…Osteoporosis was associated with primary biliary cirrhosis (PBC) and was a risk factor for vertebral fracture (Guanabens et al 2010), further studies that the links of TAA, PBC, and vertebral fracture will be necessary to establish their role in the pathogenesis of liver injury. Then again, some studies suggested vitamin K2, Zinc and selenoprotein P have important effect on bone metabolism (Lwamoto et al 2011;Pietschmann et al 2014;Sun et al 2011), insulin-like growth factor-1 (IGF-1) is a main determinant of low cortical but not trabecular bone mass (Liu et al 2018). We guess IGF-1 associated with metabolic bone disease.…”

Section: Discussionmentioning

confidence: 89%

“…Statistical signi cance differences between groups were assessed by one-way analysis of variance (Anova) followed by the Dunnett and LSD post hoc test for multiple comparisons. All data were analyzed using the SPSS statistical package version 22.0 for Windows (IBM, Armonk, NY, USA). P < 0.05 indicated a statistically signi cant difference.…”

Section: Discussionmentioning

confidence: 99%

“…Metabolic bone disease is related to patients with chronic liver disease,represented as osteoporosis, osteopenia, or osteomalacia, which increase bone pain and fracture risk (Collier 2007;Rouillard and Lane 2001). The pathogenesis of hepatic osteodystrophy (HOD) is complexed and likely is multifactorial, after its formation, HOD is hard to treat (Liu et al 2018;Moschen et al 2005;van der Merwe et al 2003). To allow an early diagnosis and nd the appropriate treatment plan, it is important to understand the mechanisms causing HOD.…”

Section: Discussionmentioning

confidence: 99%

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Acute Bone Damage Through Liver-bone Axis Induced by Thioacetamide in Rats

Li¹,

Li²,

Cheng³

et al. 2020

Preprint

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Background: Thioacetamide（TAA）is used in various fields, such as synthetic drugs, organic chemical synthesis, and materials chemistry. In the medical field, TAA is mainly used to establish animal liver injury models and other organ damage models to explore their mechanisms for helping patients with liver disease, however, TAA caused bone damage is barely understood. Therefore, the aim of our study consisted in building a rat model reflecting the TAA-treated caused acute bone damage. Results: Serum samples collected from 5-times TAA-treated rats and were used in biochemical test, we found the level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), uric acid (UA), total bile acid (TBA), alkaline phosphatase (ALP), carbamide (UREA) and creatinine (CREA) exhibited sharply rise, while the level of serum content of total protein (TP), lactate dehydrogenase (LDH), calcium (Ca) and phosphorus (P) were severely reduced. At the same time, we obtained some data about cortical bone and trabecular bone by Micro-CT analysis, it revealed significantly decreased bone surface, tissue surface, bone volume, tissue volume in TAA-treated rats, moreover, we used a static biomechanical test system to test the femoral force range of the hind limbs of SD rats, we found bone can resist less pressure and it is easy to take fracture. Conclusions: Summarizing, our rat model presents possible mediators of liver damage, liver damage and changes in bone structure and mineralization are already visible by Micro-CT analysis after five-times of TAA treatment. The fast response and easy building possibly make it an ideal model to investigate bone metabolism in liver damage after they were affected by TAA.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Acute Bone Damage Through Liver-bone Axis Induced by Thioacetamide in Rats

Li¹,

Li²,

Cheng³

et al. 2020

Preprint

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“…The researchers concluded that low bone mineral density is highly prevalent in this group of patients, and vitamin D levels and severity of liver disease are correlated with low BMD [ 4 ]. The pathogenic mechanism underlying this reduction is hypothesized in the literature to be a decrease in the proliferative capacity of osteoblasts with increasing bilirubin levels, which is dose dependent [ 4 , 5 , 24 , 25 ]. It is noteworthy that vitamin D3 is hydroxylated in the liver.…”

Section: Discussionmentioning

confidence: 99%

Osteoporosis and Jaw Abnormalities in Panoramic Radiography of Chronic Liver Failure Patients

Ghapanchi

Zahed

Haghnegahdar

et al. 2018

BioMed Research International

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Introduction Patients with chronic liver failure (CLF) are faced with many complications, because this organ is involved in various metabolic activities. Hepatic osteodystrophy is one of the major health issues encountered by this group of patients. The current study evaluated osteoporosis and bone changes in oral panoramic radiographies of cirrhotic patients. Materials and Methods In this study, 138 panoramic views of CLF patients, candidates for liver transplant (65 females, 73 males, aged 19-68 years) referred to Shiraz University Dental Clinic (Shiraz, Iran) for pretransplant oral examination, were evaluated. Also 138 healthy individuals (69 females, 69 males, aged 18-70 years) referred to the same clinic were examined. Abnormalities such as osteoporosis, pathologic radiolucencies, pathologic calcifications, tonsilloliths, condylar degeneration, and other findings in the alveolar bones were recorded. ResultsOsteoporosis was a common finding in CLF patients (p<0.001), and the probability of detecting low bone density in the panoramic view was 20.37 times higher among patients than healthy subjects. The probability of detecting pathologic jaw radiolucencies was 8.92 times higher in the case group than in the controls (p<0.001). Other bone abnormalities such as condylar degeneration and idiopathic osteosclerosis were also more prevalent in CLF patients compared to healthy subjects (p<0.001). Conclusion Cirrhotic patients are prone to osteoporosis of the alveolar bones. Also, pathologic jaw radiolucencies as a result of oral infections are more prevalent in this group of patients. Routine oral panoramic views are acceptable and cost-effective radiographies for use in detecting such abnormalities in the alveolar bones as well as overall dental health. These findings also support the importance of dental health examinations prior to liver transplantation to reduce the risk of organ rejection.

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“…Insulin-like growth factor-1 ( IGF-1 ), a polypeptide containing 70 amino acid residues, exists almost all tissues in mammals, and can accelerate cell proliferation and differentiation, functioning as a mitosis promoter for many types of cell (including osteoblasts). [10] IGF-1 pathway can regulate bone metabolism through diverse pathways. IGF-1 can facilitate the synthesis and mineralization of bone matrix through mitosis-independent pathway, and affect bone metabolism through regulating the functions of bone cells.…”

Section: Introductionmentioning

confidence: 99%

IGF-1 polymorphisms modulate the susceptibility to osteonecrosis of the femoral head among Chinese Han population

2019

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The study was performed to investigate the genetic associations of IGF-1 polymorphisms rs35767, rs5742714, and rs972936 with susceptibility to osteonecrosis of the femoral head (ONFH) among Chinese Han population. Totally, 101 ONFH patients and 128 healthy controls were enrolled. Hardy–Weinberg equilibrium (HWE) was detected with chi-square test in control group. Odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to estimate the relationship between IGF-1 polymorphisms and ONFH risk. Besides, hyplotype analysis was performed to examine linkage disequilibrium between the studied polymorphisms. Genotype AA and allele A of polymorphism rs35767 were more frequent in control group, and offered protection for ONFH onset (AA: OR = 0.382, 95% CI = 0.158-0.923; A: OR = 0.650, 95% CI = 0.442–0.956). Furthermore, the negative relationship was also observed between ONFH risk and polymorphism rs5742714 under the comparisons CG vs CC, and G vs C (OR = 0.395, 95%CI = 0.199–0.787; OR = 0.346, 95%CI = 0.191–0.627). While the polymorphism rs972936 significantly enhanced the disease risk (CT vs CC: OR = 2.434, 95% CI = 1.184–5.003; TT vs CC: OR = 2.497, 95% CI = 1.040–5.990). Furthermore, haplotype analysis demonstrated that C-T (rs5742714–rs972936) could increase ONFH risk (OR = 2.177, 95% CI = 1.444–3.283), while G-T might be a protective factor for ONFH (OR = 0.472, 95% CI = 0.254–0.878). IGF-1 polymorphisms rs35767, rs5742714, and rs972936 show significant association with ONFH risk.

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Reduced Serum IGF-1 Associated With Hepatic Osteodystrophy Is a Main Determinant of Low Cortical but Not Trabecular Bone Mass

Cited by 20 publications

References 89 publications

Acute Bone Damage Through Liver-bone Axis Induced by Thioacetamide in Rats

Acute Bone Damage Through Liver-bone Axis Induced by Thioacetamide in Rats

Osteoporosis and Jaw Abnormalities in Panoramic Radiography of Chronic Liver Failure Patients

IGF-1 polymorphisms modulate the susceptibility to osteonecrosis of the femoral head among Chinese Han population

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