Reduced risk of pancreatic cancer associated with asthma and nasal allergies

Gomez‐Rubio, Paulina; Zock, Jan‐Paul; Rava, Marta; Márquez, Mirari; Sharp, Linda; Hidalgo, Manuel; Carrato, Alfredo; Ilzarbe, Lucas; Michalski, Christoph; Molero, Xavier; Farré, Antoni; Perea, José; Greenhalf, William; O’Rorke, Michael; Tardón, Adonina; Gress, Thomas M.; Barberá, Víctor Manuel; Crnogorac‐Jurčević, Tatjana; Domínguez‐Muñoz, Enrique; Muñoz‐Bellvís, Luís; Álvarez–Urturi, Cristina; Balcells, J.; Barneo, L; Costello, Eithne; Guillén‐Ponce, Carmen; Kleeff, Jörg; Kong, Bo; Lawlor, Rita T.; Löhr, Matthias; Móra, Josefina; Murray, Liam; O’Driscoll, Damian; Peláez, Pablo; Poves, Ignasi; Scarpa, Aldo; Real, Francisco X.; Malats, Núria; Investigators, PanGenEU Study

doi:10.1136/gutjnl-2015-310442

Cited by 60 publications

(56 citation statements)

References 40 publications

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“…Using the PanGenEU case-control study database, a 2015 study examined the association between 1297 cases of pancreatic ductal adenocarcinoma (PDAC) and two distinct exposures: asthma and nasal allergy [39]. Each exposure was significantly associated with a reduction in odds of PDAC (asthma OR 0.6, 95 % CI 0.5-0.9; nasal allergy OR 0.7, 95 % CI 0.5-0.8).…”

Section: Pancreatic Cancermentioning

confidence: 99%

Atopy and Specific Cancer Sites: a Review of Epidemiological Studies

Cui

Hill

2016

Clinic Rev Allerg Immunol

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Mounting evidence appears to link asthma and atopy to cancer susceptibility. This review presents and discusses published epidemiological studies on the association between site-specific cancers and atopy. PubMed was searched electronically for publications between 1995 and 2015, and cited references were researched manually. Quantitative studies relating to atopy, allergy, or asthma and cancer were identified and tabulated. Despite many exposure-related limitations, patterns in the studies were observed. Asthma, specifically, has been observed to be a risk factor for lung cancer. A protective effect of atopic diseases against pancreatic cancer has been shown consistently in case-control studies but not in cohort studies. Allergy of any type appears to be protective against glioma and adult acute lymphoblastic leukemia. Most studies on atopic diseases and non-Hodgkin lymphoma or colorectal cancer reported an inverse association. The other sites identified had varying and non-significant outcomes. Further research should be dedicated to carefully defined exposure assessments of "atopy" as well as the biological plausibility in the association between atopic diseases and cancer.

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Section: Pancreatic Cancermentioning

confidence: 99%

Atopy and Specific Cancer Sites: a Review of Epidemiological Studies

Cui

Hill

2016

Clinic Rev Allerg Immunol

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“…One likely reason for this poor outcome is that 92% of cases are diagnosed at a late stage when cure is not possible. Established risk factors for pancreatic cancer include older age, male gender [2], cigarette smoking [3,4], long-term diabetes [5,6], and high body mass index (BMI) [7,8], while respiratory allergies have been consistently linked to lower risk [9–11]. …”

Section: Introductionmentioning

confidence: 99%

The oral microbiota in patients with pancreatic cancer, patients with IPMNs, and controls: a pilot study

Olson

Satagopan

et al. 2017

Cancer Causes Control

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Purpose Poor oral health appears to be a risk factor for pancreatic cancer, possibly implicating the oral microbiota. In this pilot study, we evaluated the characteristics of the oral microbiota in patients with pancreatic ductal adenocarcinoma (PDAC), intraductal papillary mucinous neoplasms (IPMN), and healthy controls. Methods Forty newly diagnosed PDAC patients, 39 IPMN patients, and 58 controls, excluding current smokers and users of antibiotics, provided saliva samples. Common oral bacterial species were comprehensively surveyed by sequencing of the 16S rRNA microbial genes. We obtained measures of diversity and the mean relative proportions of individual taxa. We explored the degree to which these measures differed according to respondent characteristics based on individual interviews. Results PDAC cases did not differ in diversity measures from either controls or IPMN cases. PDAC cases had higher mean relative proportions of Firmicutes and related taxa, while controls had higher mean relative proportions of Proteobacteria and related taxa. Results were generally similar when comparing PDAC to IPMN cases. Among IPMNs and controls combined, younger individuals had higher levels of several taxa within the Proteobacteria. The only other variable consistently related to mean relative proportions was mouthwash use, with taxa within Firmicutes more common among users. Conclusions While there were no differences in diversity of the oral microbiota among these groups, there were differences in the mean relative proportions of some taxa. Characteristics of the oral microbiota are not associated with most measures of oral health.

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“…The findings from one meta-analysis showed that there was no associa-tion between asthma and risk of pancreatic cancer, 20 while the results from another, more recent, meta-analysis showed consistent inverse associations between asthma and risk of pancreatic cancer as well as between nasal allergies and risk of pancreatic cancer. 6 The findings from a recent cohort study, which used a nationwide database, revealed that the associations between allergies and cancer are site specific, and that patients with more than one allergic disease had lower cancer risks compared with those with only one allergic disease. 8 Moreover, conflicting results were found between several studies examining the associations between allergies and gastric cancer risk.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7][8][9] Over the past few decades, substantial amounts of epidemiologic and clinical data have described the associations between allergic diseases and cancer. [5][6][7][8][9][10][11][12] However, to the best of our knowledge, only a few epidemiologic studies have examined the associations between allergic diseases and gastric cancer. One cohort study that analyzed subjects selected from a hospital discharge registry, reported that asthma was associated with reduced gastric cancer risk; 13 however, this study included patients with only severe asthma, and the number of gastric cancer cases was small.…”

Section: Introductionmentioning

confidence: 99%

Associations between Atopic Dermatitis and Risk of Gastric Cancer: A Nationwide Population-based Study

Kim

Lee

et al. 2018

Korean J Gastroenterol

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Background/Aims: Epidemiologic and clinical data indicate that allergies may be associated with reduced risks for several cancers; however, to date, only a few studies have examined the associations between allergies and gastric cancer. This study aimed to examine the associations between allergies and gastric cancer using a large population-based dataset. Methods: This cross-sectional study obtained data from the Korea National Health and Nutrition Examination Survey between 2010 and 2014, involving a total of 24,089 participants. The associations between allergies and gastric cancer were analyzed using univariable and multivariable logistic regression analyses with complex sampling, while adjusting for confounding factors that included age, sex, body mass index, smoking status, alcohol intake, and level of education. Results: Multivariable logistic regression analyses that were adjusted for the potential confounders determined that a history of allergic diseases tended to be associated with reduced risk of gastric cancer; however, this relationship was not statistically significant (any allergy: odds ratio [OR], 0.62; 95% confidence interval [CI], 0.34-1.12; atopic dermatitis: OR, 0.34; 95% CI, 0.50-1.72; allergic rhinitis: OR, 0.71; 95% CI, 0.34-1.46; asthma: OR, 0.44; 95% CI, 0.15-1.29). Multivariable analysis showed that a history of atopic dermatitis was associated with reduced risk of gastric cancer in men (OR, 0.16; 95% CI,. Conclusions: This findings of this study suggest that individuals with allergies tend to have a reduced risk of gastric cancer, without a statistically significant association. Furthermore, atopic dermatitis was associated with reduced risk of gastric cancer, particularly in men. (Korean J Gastroenterol 2018;71:38-44)

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Reduced risk of pancreatic cancer associated with asthma and nasal allergies

Cited by 60 publications

References 40 publications

Atopy and Specific Cancer Sites: a Review of Epidemiological Studies

Atopy and Specific Cancer Sites: a Review of Epidemiological Studies

The oral microbiota in patients with pancreatic cancer, patients with IPMNs, and controls: a pilot study

Associations between Atopic Dermatitis and Risk of Gastric Cancer: A Nationwide Population-based Study

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