Atopy and Specific Cancer Sites: a Review of Epidemiological Studies

Cui, Yubao; Hill, Andrew

doi:10.1007/s12016-016-8559-2

Cited by 40 publications

(54 citation statements)

References 110 publications

(82 reference statements)

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“…Expression levels of HDC and H2R are positively associated with increased survival in colorectal cancer patients [ 68 ], and some epidemiological studies support the association of atopy with the reduced incidence of some cancers [ 69 , 70 ], reinforcing a possible role of histamine in blocking tumour development.…”

Section: Regulatory and Immunomodulatory Functions Of Histaminementioning

confidence: 99%

Role of Histamine in Modulating the Immune Response and Inflammation

Branco

Yoshikawa

Pietrobon

et al. 2018

Mediators of Inflammation

230

187

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Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive amine, causes symptoms such as allergies and has a pleiotropic effect that is dependent on its interaction with its four histamine receptors. In this review, we discuss the dualistic effects of histamine: how histamine affects inflammation of the immune system through the activation of intracellular pathways that induce the production of inflammatory mediators and cytokines in different immune cells and how histamine exerts regulatory functions in innate and adaptive immune responses. We also evaluate the interactions between these effects.

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Section: Regulatory and Immunomodulatory Functions Of Histaminementioning

confidence: 99%

Role of Histamine in Modulating the Immune Response and Inflammation

Branco

Yoshikawa

Pietrobon

et al. 2018

Mediators of Inflammation

230

187

View full text Add to dashboard Cite

show abstract

“…To this end, several epidemiologic studies have observed history of asthma and/or allergies or higher serum IgE levels to be inversely associated with risk of various cancers (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). However, results have been inconsistent, and in fact, some research suggests that atopic disease may be associated with increased risk of cancer, potentially due to persistent immune stimulation (12,22,23).…”

Section: Introductionmentioning

confidence: 99%

Allergies and Asthma in Relation to Cancer Risk

Kantor

Hsu

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Allergies and asthma, conditions commonly characterized by immunoglobulin E-mediated atopic reactions, may decrease cancer risk via increases in immunosurveillance, but may increase risk due to persistent immune stimulation. Associations between allergies and asthma and cancer risk remain unclear, and it is unknown whether associations vary by race/ethnicity. Methods: We evaluated these associations in the Southern Community Cohort Study. At baseline (2002-2009), 64,170 participants were queried on history of allergies and asthma; participants were followed through 2011, during which time 3,628 incident, invasive cancers were identified, including 667 lung cancers, 539 breast cancers, and 529 prostate cancers. Cox proportional hazards regression was used to estimate multivariable-adjusted HRs and 95% confidence intervals (CI). Results: Neither allergies nor asthma was associated with risk of developing invasive cancer overall. Asthma was associated with increased lung cancer risk (HR, 1.25; 95% CI, 1.00-1.57), with no variation by race/ethnicity (P interaction ¼ 0.84). Conversely, history of allergies was associated with decreased lung cancer risk (HR, 0.80; 95% CI, 0.65-1.00), with an inverse association observed among non-Hispanic whites (HR, 0.65; 95% CI, 0.45-0.94) but not non-Hispanic blacks (HR, 0.95; 95% CI, 0.73-1.25; P interaction ¼ 0.10). No statistically significant associations were observed for risk of breast or prostate cancers, overall or by race/ethnicity. Conclusions: No associations were observed for risk of overall cancer, breast cancer, or prostate cancer. While asthma was associated with increased lung cancer risk, history of allergies was associated with decreased risk, an association driven by an inverse association among non-Hispanic whites. Impact: Associations pertaining to lung cancer merit follow up in a large, diverse study.

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“…Epidemiologic evidence documenting associations between allergic conditions and cancer has been mixed (16,17). The most consistent and robust inverse associations have been reported between all three allergic conditions and risk of brain cancer, with relative risks varying between 0.3 and 0.8 (17)(18)(19)(20)(21)(22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Allergies and the Subsequent Risk of Cancer among Elderly Adults in the United States

D’Arcy

Rivera

Grothen

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Allergic conditions may prevent some cancers by promoting immune surveillance. We examined associations of allergic rhinitis, asthma, and eczema with cancer risk among elderly Americans. Methods: We used Surveillance Epidemiology and End Results (SEER)-Medicare linked data to perform a case-control study. Cases were individuals with first cancer diagnosed in SEER registries (1992-2013, ages 66-99; N ¼ 1,744,575). Cancer-free controls (N ¼ 100,000) were randomly selected from Medicare and matched on sex, age, and selection year. Allergic conditions were identified using Medicare claims, and logistic regression was used to estimate adjusted ORs (aOR) with significance gauged with a Bonferroni P cutoff (P < 0.00034). Results: Allergic rhinitis, asthma, and eczema were present in 8.40%, 3.45%, and 0.78% of controls, respectively. For allergic rhinitis, strong inverse associations (aORs, 0.66-0.79) were observed for cancers of the hypopharynx, esophagus (squamous cell), cervix, tonsil/oropharynx, and vagina/vulva. More modest but significant inverse associations were noted for cancers of the esophagus (adenocarcinoma), stomach, colon, rectosigmoid/rectum, liver, gallbladder, lung, uterus, bladder, and miscellaneous sites. Associations were stronger in analyses requiring a dispensed medication to confirm the presence of allergic rhinitis. Asthma was associated with reduced risk of liver cancer [aOR 0.82; 95% confidence interval (CI), 0.75-0.91], whereas eczema was associated with elevated risk of T-cell lymphoma (aOR, 4.12; 95% CI, 3.43-4.95). Conclusions: Inverse associations with allergic rhinitis are present for multiple cancers and require etiologic investigation. Impact: Understanding of mechanisms by which allergic conditions reduce cancer risk may advance cancer prevention and treatment.

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Atopy and Specific Cancer Sites: a Review of Epidemiological Studies

Cited by 40 publications

References 110 publications

Role of Histamine in Modulating the Immune Response and Inflammation

Role of Histamine in Modulating the Immune Response and Inflammation

Allergies and Asthma in Relation to Cancer Risk

Allergies and the Subsequent Risk of Cancer among Elderly Adults in the United States

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