Reduced risk of Alzheimer's disease with high folate intake: The Baltimore Longitudinal Study of Aging

Corrada, María M.; Kawas, Claudia H.; Hallfrisch, Judith; Muller, Denis C.; Brookmeyer, Ron

doi:10.1016/j.jalz.2005.06.001

Cited by 135 publications

(84 citation statements)

References 45 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, the studies that examined the association of vitamin B 12 with AD were null (159,(176)(177)(178)(180)(181)(182) . There have been a number of randomised trials of the effects of supplementation with folic acid and vitamin B 12 on cognitive decline.…”

Section: B-vitamins Cognitive Decline and Alzheimer's Diseasementioning

confidence: 96%

Nutritional determinants of cognitive aging and dementia

2011

View full text Add to dashboard Cite

The objective of this review is to provide an overview of nutritional factors involved in cognitive aging and dementia with a focus on nutrients that are also important in neurocognitive development. Several dietary components were targeted, including antioxidant nutrients, dietary fats and B-vitamins. A critical review of the literature on each nutrient group is presented, beginning with laboratory and animal studies of the underlying biological mechanisms, followed by prospective epidemiological studies and randomised clinical trials. The evidence to date is fairly strong for protective associations of vitamin E from food sources, the n-3 fatty acid, DHA, found in fish, a high ratio of polyunsaturated to saturated fats, and vitamin B 12 and folate. Attention to the level of nutrient intake is crucial for interpreting the literature and the inconsistencies across studies. Most of the epidemiological studies that observe associations have sufficient numbers of individuals who have both low and adequate nutrient status. Few of the randomised clinical trials are designed to target participants who have low baseline status before randomising to vitamin supplement treatments, and this may have resulted in negative findings. Post-hoc analyses by some of the trials reveal vitamin effects in individuals with low baseline intakes. The field of diet and dementia is a relatively young area of study. Much further work needs to be done to understand dietary determinants of cognitive aging and diseases. Further, these studies must be particularly focused on the levels of nutrient intake or status that confer optimum or suboptimal brain functioning. Nutrition: Cognitive decline: Dementia: Antioxidant nutrients: Dietary fatsAfter more than a decade of research on nutrition and the aging brain, a number of promising nutritional factors have emerged that are also important to neurocognitive development. This review describes the evidence for these nutritional factors that show the most promise in the prevention of neurodegenerative disease. Among these are antioxidant nutrients, B-vitamins, dietary fat composition and n-3 fatty acids. Each of these factors has a body of literature to support underlying biological mechanisms for association as well as evidence of association from prospective epidemiological studies. The clinical trial evidence for vitamin supplements has been disappointing, but very few of these trials were designed to test whether supplementation is effective in persons who have low nutrient status for that particular dietary component.In general, potential recommendations to maintain a healthy brain reflect those that have been demonstrated to maintain a healthy heart: physical activity combined with a diet that has a high ratio of unsaturated to saturated fats, vegetables, fruits and fish. In this review, we first describe common neurodegenerative diseases of aging and some basic fundamentals in nutrient absorption and physiological function. These sections are followed by a review of the evidence for each die...

show abstract

Section: B-vitamins Cognitive Decline and Alzheimer's Diseasementioning

confidence: 96%

Nutritional determinants of cognitive aging and dementia

2011

View full text Add to dashboard Cite

show abstract

“…For example, the e4 allele of the Apolipoprotein E gene (APOE) has emerged as a clear genetic susceptibility factor for Alzheimer's dementia [8], although it has not resulted in effective therapeutic strategies, thus far. Numerous observational studies have reported putative protective effects in relation to dietary intake and nutritional supplementation (fish oils [9], folate [10] and vitamins E and C [11]); mental [12] and physical exercise [13]; and medications including estrogen therapy [14], non-steroidal anti-inflammatory drugs [15], and statins [16]. Unfortunately, the limited randomized clinical trials to date have not supported a role for these agents in the prevention of AD [17,18], but more studies need to be done.…”

Section: Risk and Preventive Factors And The Public Health Impact Of mentioning

confidence: 99%

Alzheimers and Dementia in the Oldest-Old: A Century of Challenges

Kawas

Corrada²

2006

CAR

View full text Add to dashboard Cite

Alzheimer's disease (AD) is the most common type of dementia in the US and much of the world with rates increasing exponentially from age 65. Increases in life expectancy in the last century have resulted in a large number of people living to old ages and will result in a quadrupling of AD cases by the middle of the century. Preventing or delaying the onset of AD could have a huge impact in the number of cases expected to develop. The oldest-old are the fastest growing segment of the population and are estimated to account for 12% of the population over 65. Establishing accurate estimates of dementia and AD rates in this group is crucial for public health planning. Prevalence and incidence estimates above age 85 are imprecise and inconsistent because of the lack of very old individuals in most studies. Moreover, risk and protective factors in our oldest citizens have been studied little, and clinical-pathological correlations appear to be poor. We introduce The 90+ Study, established to address some of the unanswered questions about AD and dementia in the oldest-old. Our preliminary results show that close to half of demented oldest-old do not have known cerebral pathology to account for their cognitive deficits. Furthermore, the APOE-e4 allele appears to be a risk factor for AD only in the women in our study. In addition to the challenge of preventing and treating AD, the oldest-old will require major investigative energy to better understand the concomitants of longevity, the causes of dementia, and the factors that promote successful aging in oldest citizens.

show abstract

“…High folate intake was associated with reduced risk of developing AD in the Baltimore Longitudinal Study of Aging (Corrada et al, 2005), but there was no association with vitamin supplement and/or food intake of folate in the Chicago Health and Aging Project (CHAP) study (Morris et al, 2006a). In both studies, no association was found with total intake of vitamins B12 or B6.…”

Section: Introductionmentioning

confidence: 95%

“…Moreover, there are a limited number of prospective cohort studies on B vitamins and dementia, and the findings have not been consistent. Very few prospective studies examined the levels of B vitamins and Hcy in relation to incidence of dementia (Luchsinger et al, 2004;Corrada et al, 2005;Ravaglia et al, 2005;Morris et al, 2006b;Luchsinger et al, 2007b;Wald et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Vitamin B complex and homocysteine status and Cognitive impairment in the elderly among Indian population

Basheer¹,

Soopy²,

Kumar³

et al. 2016

J. Neurosci. Behav. Health

View full text Add to dashboard Cite

Vitamins B complex and homocysteine has been given much attention as preventive factors against cognitive decline and dementia. Hyper homocysteinaemia has been suggested as a cause or mechanism in the development of Alzheimer's disease and other forms of dementia. The present study is designed to know the role of vitamin B complex and homocysteine and its relation with cognition, using biological samples. A total of 337 subjects with a mean age of 49 years participated in the cross sectional study from different parts of Kerala state in India. Participants were administered a series of neuropsychological test batteries with major emphasis on 7-min screen test. All test procedures were administered by standard protocol after a written consent was obtained from the participating subjects. Analysis of vitamin B complex and homocysteine was done, using serum samples and the data obtained was then statistically analyzed using statistical package for social sciences (SPSS) software version 17. Vitamin B 6 and B 9 were found to be significantly related to the cognitive score (P < 0.001, p < 0.003, respectively). Independent sample test showed a highly significant change with a p value < 0.048 and < 0.019 of vitamin B 12 and homocysteine, respectively. The results of our study give us an insight that Vitamin B complex and homocysteine may be closely associated with cognitive function in elderly population. But further studies on a larger population is required to come out with a definite conclusion.

show abstract

Reduced risk of Alzheimer's disease with high folate intake: The Baltimore Longitudinal Study of Aging

Cited by 135 publications

References 45 publications

Nutritional determinants of cognitive aging and dementia

Nutritional determinants of cognitive aging and dementia

Alzheimers and Dementia in the Oldest-Old: A Century of Challenges

Vitamin B complex and homocysteine status and Cognitive impairment in the elderly among Indian population

Contact Info

Product

Resources

About