Reduced Relative Lymphocyte Count in African-Americans With Decompensated Heart Failure

Ali, Sheharyar; Shahbaz, Atta U.; Nelson, M. D.; Weber, Karl T.; Shirwany, Arsalan; Ahmad, Mahmood; D’cruz, Ivan C.

doi:10.1097/maj.0b013e318182198f

Cited by 11 publications

(4 citation statements)

References 43 publications

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“…Bian et al reported that decreased lymphocyte levels can be used as a marker of acute coronary syndrome, [24] and several other studies have shown that a reduced percentage of lymphocytes in patients with acute heart failure is associated with morbidity and mortality. [25,26] However, Cooper et al reported that an increased neutrophil count could also be a marker of mortality in cases with left ventricular dysfunction. [27] Similar to these studies, we found that blood neutrophil levels were significantly increased and lymphocyte counts were significantly decreased in patients with RAO than in control subjects.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Patients with RetinalArtery Occlusion

Atum

Alagöz

2020

JOVR

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Purpose: This study aimed to compare the neutrophil-to-lymphocyte (NLR) and plateletto- lymphocyte (PLR) ratios in patients with retinal artery occlusion (RAO) with those from a healthy control population and to identify the relationship between them. Methods: Forty-six patients with RAO and fifty-one healthy control subjects were included in this retrospective case-control study. RAO was diagnosed following an ophthalmic examination and fluorescein angiography (FA). Blood neutrophil, lymphocyte, and platelet counts were recorded for each of the 97 subjects, from which NLR and PLR values were calculated. Results: There were 46 patients (28 male [M], 18 female [F]) in the RAO group and 51 patients (27 M, 24 F) in the control group. No significant differences were found between patients with RAO and the control subjects in terms of gender and age (P > 0.05). Patients with RAO had significantly increased NLR values (2.85 ± 1.70) than the control subjects (1.63 ± 0.59, P < 0.001). The mean PLR in patients with RAO was 123.69 ± 64.98, while that in control subjects was 103.08 ± 36.95; there was no significant difference between the two groups (P = 0.055). A logistic regression analysis revealed that NLRs were 3.8 times higher in patients with RAO than in control subjects (odds ratio = 3.880; 95% confidence interval = 1.94 to 7.74; P < 0.001). Conclusion: NLRs were significantly increased in patients with RAO compared to the control subjects.

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Section: Discussionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Patients with RetinalArtery Occlusion

Atum

Alagöz

2020

JOVR

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“…Bian and colleagues found that a low percentage of lymphocytes could be used as an independent predictor of acute coronary syndrome on admission (22). Studies have shown that a decreased relative percentage of lymphocytes is associated with morbidity and mortality in AHF patients (23,24). In addition, similar studies reported an association with an increased number of neutrophils.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio and in-hospital mortality in patients with acute heart failure

Turfan¹,

Erdoğan²,

Taşal³

et al. 2014

Clinics

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OBJECTIVES:Previous studies have demonstrated the role of inflammation in acute heart failure. The neutrophil-to-lymphocyte ratio was found to be a useful inflammatory marker for predicting adverse outcomes. We hypothesized that an elevated neutrophil-to-lymphocyte ratio would be associated with increased mortality in acute heart failure patients.METHODS:The study cohort consisted of 167 acute heart failure patients with an ejection fraction <50%. The primary endpoint was in-hospital mortality, and the patients were divided into two groups according to in-hospital mortality.RESULTS:In a multivariate regression analysis, including baseline demographic, clinical, and biochemical covariates, the neutrophil to lymphocyte ratio remained an independent predictor of mortality (OR 1.156, 95% CI 1.001 - 1.334, p = 0.048).CONCLUSION:In conclusion, an elevated neutrophil-to-lymphocyte ratio seems to be a predictor of short-term mortality in patients with acute heart failure and a reduced left ventricular ejection fraction.

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“…Monocyte activation and its differentiation to lipid-loaded macrophages have important role in the formation of atherosclerotic lesions. 5 –8 High-density lipoprotein cholesterol (HDL-C) has a protective role in cardiovascular diseases due to its anti-inflammatory, antioxidant, and antithrombotic properties. 9 Besides, a relationship between high number of monocytes and low HDL-C levels has been reported in inflammatory disorders.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Monocyte to High-Density Lipoprotein Cholesterol Ratio in the Presence and Severity of Metabolic Syndrome

Uslu

Sekin

Tarhan

et al. 2017

Clin Appl Thromb Hemost

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Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a systemic inflammatory marker, and recently, it has been used quite commonly for the assessment of inflammation in cardiovascular disorders. The aim of the present study is to investigate the relevance of MHR as a marker to assess metabolic syndrome (MetS) and MetS severity in clinical practice. A total of 147 patients with MetS who were diagnosed according to National Cholesterol Education Program Adult Treatment Panel III criteria and 134 healthy controls, matched for age and gender, were included in our retrospective study. MHR values were 13.15 + 6.07 for patients with MetS and 9.74 + 5.24 for the control group. MHR values of the patients were found to be statistically significantly higher than the control group (P < .0001). MHR showed a significantly positive correlation with the severity of MetS (r ¼ .429; P < .0001). When patients with MetS were assessed with MHR in the study population, receiver-operating characteristic curve analysis yielded a cutoff value of 9.36 with a sensitivity of 72%, a specificity of 61%, and a P value <.0001. In logistic regression analyses of MetS with several variables, MHR remained as an independent predictor of MetS (95% CI: 0.721-0.945, P ¼ .005). MHR might be an available and useful inflammatory marker to evaluate patients with MetS and disease severity.

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Reduced Relative Lymphocyte Count in African-Americans With Decompensated Heart Failure

Cited by 11 publications

References 43 publications

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Patients with RetinalArtery Occlusion

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Patients with RetinalArtery Occlusion

Neutrophil-to-lymphocyte ratio and in-hospital mortality in patients with acute heart failure

Evaluation of Monocyte to High-Density Lipoprotein Cholesterol Ratio in the Presence and Severity of Metabolic Syndrome

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