Reduced relapse rate in duodenal ulcer disease leads to normalization of psychological distress: twelve‐year follow‐up

Abstract

Normalization of anxiety and neuroticism following cure of DU disease supports the view that the increased anxiety and neuroticism are consequences, and not causes, of the disease.

Editorial: noncoeliac gluten sensitivity - a disease of the mind or gut?

“…This improvement in psychological functioning may be the result of symptomatic resolve and enhanced perception of health and psychological wellbeing. 5 In contrast, the induction of current feelings of depression following the consumption of gluten in this study points to a causative (not associative) role of gluten on mental state. The mechanistic action by which gluten might induce these changes in noncoeliac gluten sensitivity (NCGS) remains unknown.…”

“…4 It has been noted that treatment of the underlying disease process can lead to alleviation of anxiety and neuroticism. 5 This may also be the case in NCGS subjects who exhibit low levels of somatisation while on a GFD, 6 with Peters et al subsequently demonstrating blinded gluten exposure to induce a state of depression. 1 These findings are similar to that seen in coeliac disease where depression is commonly reported, 7 and a GFD in symptomatic individuals leads to an improvement in perception of health and psychological well-being.…”

Comorbidity of irritable bowel syndrome in general practice: a striking feature with clinical implications

“…8,15 The observed levels of health anxiety and neuroticism are also likely to be higher than in a population without IBS, although we have no control group in our study to confirm these differences. 16 Symptoms of IBS were in most patients, regardless of gender, of mild-to-moderate intensity, long-standing IBS, irritable bowel syndrome; OR, odds ratio; CI, confidence interval. All differences (both for any and substantial complaints) are statistically significant (P < 0.001) with the exception of eczema and colds, flu.…”

“…In the 166 patients, 145 patients (87%) reported abdominal pain/ discomfort within the last 3 months. The intensity of abdominal pain/discomfort was significantly lower at follow-up (mean 3.6, s. Table 3 gives the characteristics differences between patients with low (score £ 6), intermediate (score [7][8][9][10][11][12][13][14][15][16] and high SC (score >16). At follow-up, patients with high SC reported higher intensity of abdominal pain/discomfort than patients with intermediate or low comorbidity, with mean scores of 4.4, 3.3 and 2.8 respectively (P ¼ 0.02).…”

Intestinal autointoksikasjon - fortsatt aktuell sykdomsmekanisme?

“…Denne dysfunksjonen trenger imidlertid ikke å vaere sentralnervøs, slik Bruusgaard & Natvig foreslår, men kan like gjerne vaere mikrobiell (14). Magesårsykdommen er et godt eksempel: Ved eliminasjon av den mikrobielle årsaken (Helicobacter pylori-infeksjon), forsvinner nemlig både de somatiske og de psykiske manifestasjonene (15). Medisinsk uforklarte plager og symptomer tilskrives gjerne forstyrrelser i samspillet mellom psyke og soma -men mennesker består av mer enn kropp og sjel (fig 1).…”