Reduced quality of life when experiencing menstrual pain in women with primary dysmenorrhea

Iacovides, Stella; Avidon, Ingrid; Bentley, Alison; Baker, Fiona C.

doi:10.1111/aogs.12287

Cited by 124 publications

(90 citation statements)

References 18 publications

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“…Collectively, these are common gynecological complications in women. Regardless of the cause, dysmenorrhea can have a substantial impact on patient quality of life,7,8 yet many patients do not seek treatment 9. In a patient survey, some untreated women have expressed feelings of resistance or aversion toward seeking therapy, and many suggested that gynecologist consultations were unnecessary for their disorder 1.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the treatment patterns and economic burden of dysmenorrhea in Japanese women, using a claims database

Akiyama¹,

Tanaka²,

Cristeau³

et al. 2017

CEOR

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PurposeThis study aimed to describe treatment patterns and estimate health care resource utilization and associated costs among Japanese women with dysmenorrhea, using a claims database.MethodsThis was a retrospective analysis using health insurance data from the Japan Medical Data Center, assessing female patients aged 18–49 years with newly diagnosed primary or secondary dysmenorrhea. Treatment pattern analyses focused on hormonal medications, analgesics, hemostatic agents, traditional Chinese medicine (TCM), and gynecological surgeries. Data were collected on health care resource utilization and costs associated with medications, imaging procedures, and inpatient and outpatient care in both patients and matched controls.ResultsThe analysis included 6,315 women with dysmenorrhea (3,441 primary; 2,874 secondary). The most commonly prescribed initial therapies were low-dose estrogen progestins (LEPs, 37.7%) and TCM (30.0%), with substantial differences between primary (LEPs: 27.4%, TCM: 38.8%) and secondary (LEPs: 50.2%, TCM: 19.5%) dysmenorrhea cohorts. Surgery was conducted in <5% of all patients. Both primary and secondary cohorts of dysmenorrhea had significantly higher mean total health care costs compared to controls within the 1-year period following diagnosis (Case-primary: 191,680 JPY [1,916 USD]; secondary: 246,488 JPY [2,465 USD], Control-primary: 83,615 JPY [836 USD]; secondary: 90,711 JPY [907 USD]) (p<0.0001). After adjusting for baseline characteristics, these costs were 2.2 and 2.9 times higher for primary and secondary dysmenorrhea cohorts, respectively, compared with matched controls, (both p<0.0001). The main driver of these excess costs was outpatient care, with eight additional physician visits per year among dysmenorrhea patients compared to controls (p<0.0001).ConclusionConsiderable heterogeneity in treatment patterns was observed, with relatively low utilization of LEPs in patients with primary dysmenorrhea and those treated by internal medicine physicians. Total annual health care costs were approximately 2–3 times higher in patients with dysmenorrhea compared to women without the condition.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the treatment patterns and economic burden of dysmenorrhea in Japanese women, using a claims database

Akiyama¹,

Tanaka²,

Cristeau³

et al. 2017

CEOR

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“…This also applies to Japanese women [14–16]. In addition to physiological characteristics, menstrual cycle-related symptoms affect health-related quality of life [17]. According to an epidemiological study, average scores of students with premenstrual syndrome were significantly lower in all domains of quality of life [18, 19].…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular response to short-term fasting in menstrual phases in young women: an observational study

Okita

Kouda

Mase³

et al. 2015

BMC Women's Health

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BackgroundMenstrual cycle-related symptoms are an important health issue for many women, and some may affect cardiac autonomic regulation. In the present study, we evaluated the cardiovascular and physiological stress response to 12-h short-term fasting in the menstrual phases of healthy young women.MethodsWe performed a randomized crossover study. Subjects were seven female university students (age: 22.3 ± 1.0 years). The experiments comprised four sessions: meal intake in the follicular phase, meal intake in the luteal phase, fasting in the follicular phase, and fasting in the luteal phase. All subjects participated in a total of four experimental sessions during two successive phases (follicular and luteal phase in the same menstrual cycle, or luteal phase and follicular phase in the next menstrual cycle) according to a randomized crossover design. R-R intervals were continuously recorded before and after meals, and power spectral analysis of heart rate variability was performed. Other physiological data were obtained before and 20, 40, 60, and 80 min after meal intake or after the corresponding time point of meal intake (fasting in the follicular or luteal phase).ResultsHeart rate decreased during fasting in the follicular and luteal phases. High frequency power increased during fasting in the follicular and luteal phases. In addition, salivary cortisol concentrations decreased during fasting in the luteal phase.ConclusionsIn the present study, short-term fasting resulted in higher parasympathetic activity and lower cortisol levels in the luteal phase in these young women. These results indicate a possibility to produce an anti-stress effect in the luteal phase, which may reduce menstrual symptoms.

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“…The prevalence of dysmenorrhea varies greatly across different countries (16-91% [5][6][7]; of which, 2-40% report as being moderate to severe [4,8]. Dysmenorrhea is one of the most common menstrual disorders, and if accompanied by symptoms such as headache, fatigue, nausea, vomiting, diarrhea, impatience, chills, and muscle cramps can disrupt the quality of life and social activities of young women [9,10]. Primary dysmenorrhea is more common and has good prognosis.…”

Section: Introductionmentioning

confidence: 99%

Depression, anxiety, stress, and dysmenorrhea: a protocol for a systematic review

et al. 2020

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Background: Dysmenorrhea is one of the most common menstrual disorders and is influenced by various factors. Psychological disorders including anxiety, depression, and stress have been suggested as influencing dysmenorrhea, but previous findings are inconsistent. This study will investigate the relationship between depression/anxiety/stress and dysmenorrhea using a systematic review and meta-analysis. Methods: Online databases including PsycINFO, Scopus, PubMed, Science Direct, ProQuest, ISI Web of Knowledge, and Embase will be searched. Appropriate keywords and MeSH terms will be used to retrieve the journal papers published from 1990 until the end of December 2019. To improve search coverage, the reference lists of all included studies will be reviewed to find eligible papers. Inclusion criteria include the following: descriptive, cohort, case-control, and cross-sectional studies; the relationship between depression/anxiety/stress and dysmenorrhea being an objective of the study; and published in peer-reviewed journals. The paper selection, data extraction, and quality assessment of selected studies will be performed independently by two researchers, and disagreements will be resolved through discussions. The Newcastle-Ottawa Quality Assessment Scale will be used to assess the quality of selected studies. A quantitative synthesis will be performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) via the STATA software, if retrieving enough number of studies with no severe methodological heterogeneities. Otherwise, qualitative synthesis will be used to report the findings. Discussion: To the best of our knowledge, this will be the first systematic review on this topic. Performing an inclusive search in major databases over a wide timescale is one key strength of the proposed study and will maximize the coverage of the original research studies on this topic. Results of present study are expected to lead to deeper understanding the relationship between common mental health conditions and dysmenorrhea. Systematic review registration: PROSPERO CRD42018102199

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Reduced quality of life when experiencing menstrual pain in women with primary dysmenorrhea

Cited by 124 publications

References 18 publications

Evaluation of the treatment patterns and economic burden of dysmenorrhea in Japanese women, using a claims database

Evaluation of the treatment patterns and economic burden of dysmenorrhea in Japanese women, using a claims database

Cardiovascular response to short-term fasting in menstrual phases in young women: an observational study

Depression, anxiety, stress, and dysmenorrhea: a protocol for a systematic review

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