Reduced postprandial GLP‐1 responses in women with gestational diabetes mellitus

Abstract

Pregnancy is associated with reduced postprandial GLP-1 responses (most pronounced in patients with GDM) that normalize after delivery. In contrast, postprandial GIP responses seem unaffected by pregnancy but is increased in GDM patients.

Plasma YKL-40 during pregnancy and gestational diabetes mellitus

“…Initially nineteen pregnant women were included (11 women with GDM and 8 healthy controls) (Bonde et al, 2013). The women had not been diagnosed with diabetes before pregnancy and had no first or second-degree relatives with diabetes.…”

“…Participants and characteristics have previously been reported (Bonde et al, 2013;Hare et al, 2014).…”

“…The methods have previously been described in detail (Bonde et al, 2013). On each experimental day, the participants met in the laboratory after a 10 hour fast, rested in supine position and had an intravenous catheter inserted into a cubital vein.…”

Postprandial incretin and islet hormone responses and dipeptidyl-peptidase 4 enzymatic activity in patients with maturity onset diabetes of the young

“…Insulin resistance was calculated according to the homoeostasis model assessment (HOMA-IR) (32). The number of participants was based on similar studies in other populations (12,18,33,34,35,36).…”

The associations of incretin hormone concentration with gestational diabetes mellitus

“…Известно, что продуктом гена глюкагона, экс-прессируемого в интестинальных L-клетках, является проглюкагон, из которого под действием прогормон-конвертазы (PC1/3) образуется ГПП-1 [9,10]. Хотя экс-прессия гена глюкагона в α-клетках поджелудочной железы также приводит к образованию проглюкагона, ранее считалось, что α-клетки не способны синтезиро-вать ГПП-1.…”