Reduced polydopamine nanoparticles incorporated oxidized dextran/chitosan hybrid hydrogels with enhanced antioxidative and antibacterial properties for accelerated wound healing

Fu, Yu; Zhang, Jianhua; Wang, Yilin; Li, Jie; Bao, Jianxu; Xu, Xu; Zhang, Chaoqun; Li, Yiwen; Wu, Haoxing; Gu, Zhipeng

doi:10.1016/j.carbpol.2020.117598

Cited by 109 publications

(79 citation statements)

References 46 publications

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“…PDA-NPs are now emerging in the field of antibacterial application, particularly with the wound healing in TE. Fu et al ( Fu et al, 2021 )found that treating PDA-NPs with ascorbic acid was a simple strategy to obtain reduced PDA-NPs (rPDA-NPs), which showed improved antioxidative and antibacterial activity. Thus, the oxidized dextran/chitosan composite hydrogel incorporated with rPDA-NPs promoted the healing of infected full-thickness wound in rat dorsal skin.…”

Section: Biomedical Applications Of Pda-nps In Tementioning

confidence: 99%

Research Progress on Polydopamine Nanoparticles for Tissue Engineering

et al. 2021

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Tissue engineering is an interdisciplinary field that aims to develop biological substitutes for the replacement, repair, or enhancement of tissue function. The physical and chemical characteristics of biomaterials exert a profound influence on the biological responses and the following biofunction. Nanostructured coatings have been widely applied as an effective surface modification strategy to improve the bioactivity of biomaterials. Especially, polydopamine and polydopamine-derived nanoparticles are found with excessive adhesiveness, redox activity, photothermal conversion capacity, paramagnetism and conductivity other than excellent biocompatibility, and hydrophilicity. In this article, advances about polydopamine nanoparticles in tissue engineering applications are reviewed, including the repair of bone, cartilage, skin, heart, and nerve, to provide strategies for future biomaterial design.

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Section: Biomedical Applications Of Pda-nps In Tementioning

confidence: 99%

Research Progress on Polydopamine Nanoparticles for Tissue Engineering

et al. 2021

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“…There were no significant differences among the groups. Studies report that the application dopamine reduces the stiffness and strength of hydrogel, which may relate to the hydrogel substrate, composition, and pore structures [ 29 , 30 ]. Moreover, the mechanical properties of the synthesized hydrogels were in the range of those of biological tissues, such as the skin and articular cartilage [ 31 ], which is beneficial for biocompatibility.…”

Section: Resultsmentioning

confidence: 99%

More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing

Zhang

et al. 2021

J Nanobiotechnol

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Background During wound healing, the overproduction of reactive oxygen species (ROS) can break the cellular oxidant/antioxidant balance, which prolongs healing. The wound dressings targeting the mitigation of ROS will be of great advantages for the wound healing. puerarin (PUE) and ferulic acid (FA) are natural compounds derived from herbs that exhibit multiple pharmacological activities, such as antioxidant and anti-inflammatory effects. Polydopamine (PDA) is made from natural dopamine and shows excellent antioxidant function. Therefore, the combination of natural antioxidants into hydrogel dressing is a promising therapy for wound healing. Results Hydrogel wound dressings have been developed by incorporating PUE or FA via PDA nanoparticles (NPs) into polyethylene glycol diacrylate (PEG-DA) hydrogel. This hydrogel can load natural antioxidant drugs and retain the drug in the gel network for a long period due to the presence of PDA NPs. Under oxidative stress, this hydrogel can improve the activity of superoxide dismutase and glutathione peroxidase and reduce the levels of ROS and malondialdehyde, thus preventing oxidative damage to cells, and then promoting wound healing, tissue regeneration, and collagen accumulation. Conclusion Overall, this triple antioxidant hydrogel accelerates wound healing by alleviating oxidative injury. Our study thus provides a new way about co-delivery of multiple antioxidant natural molecules from herbs via antioxidant nanoparticles for wound healing and skin regeneration. Graphic Abstract

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“…designed several reduced PDA NPs to improve the antioxidative capacity of PDA NPs. The reduced PDA NPs, as an antioxidant, were loaded in hydrogel dressings to avoid the stimulation of external oxidative stress on cells for expedited wound healing [ 107 ].…”

Section: Ros-scavenging Nanomaterials That Promote Oxidative Damage Repair and Mechanisms Governing This Repairmentioning

confidence: 99%

Reactive-oxygen-species-scavenging nanomaterials for resolving inflammation

Huang

Zheng

et al. 2021

Materials Today Bio

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Reactive oxygen species (ROS) mediate multiple physiological functions; however, the over-accumulation of ROS causes premature aging and/or death and is associated with various inflammatory conditions. Nevertheless, there are limited clinical treatment options that are currently available. The good news is that owing to the considerable advances in nanoscience, multiple types of nanomaterials with unique ROS-scavenging abilities that influence the temporospatial dynamic behaviors of ROS in biological systems have been developed. This has led to the emergence of next-generation nanomaterial-controlled strategies aimed at ameliorating ROS-related inflammatory conditions. Accordingly, herein we reviewed recent progress in research on nanotherapy based on ROS scavenging. The underlying mechanisms of the employed nanomaterials are emphasized. Furthermore, important issues in developing cross-disciplinary nanomedicine-based strategies for ROS-based inflammatory conditions are discussed. Our review of this increasing interdisciplinary field will benefit ongoing studies and clinical applications of nanomedicine based on ROS scavenging.

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Reduced polydopamine nanoparticles incorporated oxidized dextran/chitosan hybrid hydrogels with enhanced antioxidative and antibacterial properties for accelerated wound healing

Cited by 109 publications

References 46 publications

Research Progress on Polydopamine Nanoparticles for Tissue Engineering

Research Progress on Polydopamine Nanoparticles for Tissue Engineering

More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing

Reactive-oxygen-species-scavenging nanomaterials for resolving inflammation

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