Reduced olfactory performance in patients with major depression

Pause, Bettina M.; Miranda, Alejandra; Göder, Robert; Aldenhoff, Josef B.; Ferstl, Roman

doi:10.1016/s0022-3956(01)00029-2

Cited by 240 publications

(235 citation statements)

References 37 publications

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“…No difference between groups was observed for pleasant stimuli. These last results for pleasant stimuli are in accordance with the literature (Pause et al, 2001;Thomas et al, 2002;Swiecicki et al, 2009;Clepce et al, 2010). However, for the cited above studies the calculation method of the subjects' pleasantness considers all the odors irrespective of the hedonic valence of the stimuli.…”

Section: Discussionsupporting

confidence: 90%

“…Thirdly, we cannot rule out the possibility that our results were affected by specific medication. Nevertheless, previous studies on olfaction failed to find any effects of standard psychotropic medication (Martzke et al, 1997;Pause et al, 2001). At last, we can also hypothesize that our results could be due to the changes in of autonomic regulation of the heart in depression, such as activation of the sympathetic nervous system.…”

Section: Discussionmentioning

confidence: 46%

“…Earlier, Pause et al (2001) found that only one odour (citral) out of the ten studied was perceived as significantly more pleasant by depressed patients than by controls. No difference between the hedonic scores of MDD patients and controls was observed by three studies (Thomas et al, 2002;Swiecicki et al, 2009;Clepce et al, 2010).…”

Section: Olfactory Hedonic Response and Depressionmentioning

confidence: 87%

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Hedonic Olfactory Perception in Depression: Relationship between Self-Evaluation and Autonomic Response

Atanasova¹,

Gaillard²,

Minier³

et al. 2012

PSYCH

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This study aimed to improve the understanding of hedonic perception in depression using the olfactory modality. We evaluated physiological (heart rate measures) and hedonic responses (subjective rating scale) obtained from 30 unipolar depressed inpatients and 30 healthy controls. The stimuli were two odorants with contrasting hedonic valence, vanillin (pleasant) and butyric acid (foul-smelling), presented at three different concentrations and in nine binary mixtures. Compared to controls, the depressed subjects had significantly increased heart rate response to olfactory stimuli, regardless of valence. These observations were not related to the severity of depression. For both groups, a significant negative correlation was found between the explicit hedonic rating and the implicit instantaneous heart rate measure. Together these pilot findings suggest that unipolar depression is associated with stronger physiological reactions to odorants and a negative bias when processing olfactory stimuli. Further studies are required to confirm these observations in larger groups of depressed subjects.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 46%

Section: Olfactory Hedonic Response and Depressionmentioning

confidence: 87%

See 1 more Smart Citation

Hedonic Olfactory Perception in Depression: Relationship between Self-Evaluation and Autonomic Response

Atanasova¹,

Gaillard²,

Minier³

et al. 2012

PSYCH

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“…It is interesting that both depression and amphetamine withdrawal in humans are associated with diminished interest in reward stimuli and accumulated data suggest potential common neurobiological substrates underlying depressive states observed in these psychiatric conditions (Paterson and Markou, 2007). While olfactory dysfunction has been reported in patients with depression (Pause et al, 2001;Satoh et al, 1996), the association of this phenomena with depressive-like symptoms related to amphetamine withdrawal remains to be evaluated. Effects of amphetamine (AMPH) administration on the dopamine (DA), DOPAC levels and DOPAC/DA ratios in the olfactory bulb (A) and striatum (B).…”

Section: Discussionmentioning

confidence: 99%

Amphetamine causes dopamine depletion and cell death in the mouse olfactory bulb

Atianjoh

Ladenheim

Krasnova

et al. 2008

European Journal of Pharmacology

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Amphetamine is a neurotoxic psychostimulant that causes dopamine depletion and neuronal death in the rodent striatum. In the present study, we sought to determine if toxic doses of the drug can also induce pathological changes in the mouse olfactory bulb. We found that injections of amphetamine (10 mg/kg × 4, given 2 h apart) caused significant decreases in dopamine levels in that structure. This dose of the drug also induced substantial increases in the number of terminal deoxynucleotidyl transferase-mediated deoxyribonucleotide triphosphate (dNTP) nick end labeling (TUNEL)-positive cells in the olfactory bulb indicative of elevated DNA fragmentation. These results show that the toxic effects of amphetamine involve the olfactory bulb in addition to the striatum. These observations need to be taken into consideration when discussing the clinical course of amphetamine addiction.

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“…10,11,15,[18][19][20] Similarly, intensity ratings of various odors did not differ between psychiatric inpatients with depressive episode and control subjects. 11,12,17 In some of these studies, 12 positive correlations were found between olfactory deficits and the self-rated intensity of depressive symptoms assessed by the Beck Depression Inventory (BDI). 21 In contrast, olfactory measures were not correlated with the clinician-rated severity of depression measured with the Hamilton Depression Rating Scale (HAM-D).…”

mentioning

confidence: 99%

Depressive symptoms and olfactory function in older adults

Ścińska

Wróbel

Korkosz

et al. 2008

Psychiatry Clin Neurosci

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Aims: Neuroimaging studies suggest a significant overlap between brain regions involved in the regulation of olfaction and mood. The aim of the present study was to search for correlations between depressive symptomatology measured by the 15-item Geriatric Depression Scale (GDS) and olfactory function assessed with Sniffin' Sticks in non-demented older adults (aged 53-79 years).Methods: Taste detection thresholds were also measured by means of electrogustometry on the anterior tongue. Results:No correlation was found between the GDS scores (range: 0-12) and olfactory thresholds or olfactory identification scores. Similarly, there was no relationship between depressive symptoms and electrogustometric thresholds. Subjects (n = 25) scoring Ն5 on the GDS were classified as 'depressed' and all other individuals (n = 60) were classified as 'nondepressed'. The two groups did not differ in terms of the olfactory measures and electrogustometric threshold. Conclusion:Depressive symptoms are not associated with any major olfactory deficit in non-clinical older adults.

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Reduced olfactory performance in patients with major depression

Cited by 240 publications

References 37 publications

Hedonic Olfactory Perception in Depression: Relationship between Self-Evaluation and Autonomic Response

Hedonic Olfactory Perception in Depression: Relationship between Self-Evaluation and Autonomic Response

Amphetamine causes dopamine depletion and cell death in the mouse olfactory bulb

Depressive symptoms and olfactory function in older adults

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