Depressive symptoms and olfactory function in older adults

Ścińska, Anna; Wróbel, Elżbieta; Korkosz, Agnieszka; Zatorski, Paweł; Sienkiewicz-Jarosz, Halina; Łojkowska, Wanda; Święcicki, Łukasz; Kukwa, Wojciech

doi:10.1111/j.1440-1819.2008.01824.x

Cited by 44 publications

(40 citation statements)

References 50 publications

(88 reference statements)

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“…This paradigm has been used to study reduced liking in depressed patients and shows mixed findings in terms of sensitivity. While some studies show reduced sensitivity to pleasant gustatory and olfactory stimuli (Berlin et al, 1998; Pause et al, 2001; Lombion-Pouthier et al, 2006; Clepce et al, 2010; Negoias et al, 2010), other studies report normal levels of identification and perception thresholds in depressed patients (Scinska et al, 2004, 2008; Swiecicki et al, 2009; Clepce et al, 2010). …”

Section: Reconceptualizing Anhedoniamentioning

confidence: 99%

Reconceptualizing anhedonia: novel perspectives on balancing the pleasure networks in the human brain

Thomsen

Whybrow

Kringelbach

2015

Front. Behav. Neurosci.

146

154

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Anhedonia, the lack of pleasure, has been shown to be a critical feature of a range of psychiatric disorders. Yet, it is currently measured primarily through subjective self-reports and as such has been difficult to submit to rigorous scientific analysis. New insights from affective neuroscience hold considerable promise in improving our understanding of anhedonia and for providing useful objective behavioral measures to complement traditional self-report measures, potentially leading to better diagnoses and novel treatments. Here, we review the state-of-the-art of hedonia research and specifically the established mechanisms of wanting, liking, and learning. Based on this framework we propose to conceptualize anhedonia as impairments in some or all of these processes, thereby departing from the longstanding view of anhedonia as solely reduced subjective experience of pleasure. We discuss how deficits in each of the reward components can lead to different expressions, or subtypes, of anhedonia affording novel ways of measurement. Specifically, we review evidence suggesting that patients suffering from depression and schizophrenia show impairments in wanting and learning, while some aspects of conscious liking seem surprisingly intact. Furthermore, the evidence suggests that anhedonia is heterogeneous across psychiatric disorders, depending on which parts of the pleasure networks are most affected. This in turn has implications for diagnosis and treatment of anhedonia.

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Section: Reconceptualizing Anhedoniamentioning

confidence: 99%

Reconceptualizing anhedonia: novel perspectives on balancing the pleasure networks in the human brain

Thomsen

Whybrow

Kringelbach

2015

Front. Behav. Neurosci.

146

154

View full text Add to dashboard Cite

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“…The cancer exhibits a wide spectrum of behavior, ranging from indolent progression, with patients surviving Ͼ20 years, to rapid widespread metastatic disease, with survival durations of only a few months. Five-year survival rates are reported to be in the range of 45%-62% [7][8][9][10]. The Kadish staging system divides pa- tients into: A, limited to the nasal cavity; B, lesions involving the nasal cavity and paranasal sinuses; and C, extension beyond the nasal cavity and paranasal sinuses.…”

Section: Discussionmentioning

confidence: 99%

“…Radiation therapy has been used in conjunction with surgery, either pre-or postoperatively in some centers, and as definitive treatment for patients with unresectable disease. In some centers, chemotherapy, alone or in combination with radiation, has been used in the neoadjuvant setting to downstage tumors prior to surgery [7][8][9][10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

Esthesioneuroblastoma (Olfactory Neuroblastoma) with Ectopic ACTH Syndrome: A Multidisciplinary Case Presentation from the Joan Karnell Cancer Center of Pennsylvania Hospital

et al. 2010

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The case of a patient with recurrent esthesioneuroblastoma complicated by ectopic adrenocorticotropic hormone production is presented, including the workup and management of this uncommon complication of an uncommon disease. The Oncologist 2010;15: 51-58 CASE PRESENTATIONIn 1992, a 55-year-old white man presented with epistaxis and was diagnosed with esthesioneuroblastoma. He underwent a craniofacial resection with postoperative radiation therapy to his tumor site. In 1996, he relapsed in the cervical lymph nodes and underwent a bilateral cervical lymph node dissection. In total, eight positive lymph nodes were removed. He was then treated with chemotherapy with etoposide and cisplatin for four cycles. Although radiation therapy to the neck was recommended, the patient refused. In 1998, he relapsed again in the left submandibular area, and two involved lymph nodes were resected. He then agreed to and received radiation therapy to both sides of the neck. In 2002, he had evidence of further disease progression in the posterior nasopharynx and a left preauricular node. In 2004, he was treated with etoposide and carboplatin for four cycles with a minor response. Following that, he was observed without further therapy, given the indolent nature of his disease and minimal symptoms. He did, however, experience focal seizures, occasional epistaxis, hyponatremia, hypothyroidism, and an episode of pneumococcal meningitis.In August 2007, he developed fatigue, confusion, severe hypertension, and proximal muscle weakness. Laboratory studies revealed a serum glucose level of 228 mg/dl (normal, 70 -99 mg/dl), serum potassium of 2.9 mmol/l (normal, 3.5-5.1 mmol/l), pH of 7.570 (normal, 7.350 -7.450

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“…[47][48][49]) oraz studiów klinicznych [50]. Ze względu na możliwość diagnozy różnych aspektów funkcjonowania węchu, SST może być bardzo przydatnym narzędziem zarówno dla praktyków, jak i naukowców zajmujących się węchem z bardziej teoretycznej perspektywy.…”

Section: Omówienieunclassified