Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression

Negoiaș, Simona; Croy, Ilona; Gerber, Johannes; Puschmann, Sebastian; Petrowski, Katja; Joraschky, Peter; Hummel, Thomas

doi:10.1016/j.neuroscience.2010.05.012

Cited by 258 publications

(243 citation statements)

References 58 publications

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“…It has previously been shown that OB volume positively correlates with olfactory function in children and during aging and is reduced in neuropsychiatric conditions, accompanied by losses in olfactory sensitivity (36,37). We observed reduced olfactory sensitivity as well as impaired olfactory discrimination in human patients carrying heterozygous mutations in TSHZ1.…”

Section: Discussionsupporting

confidence: 53%

TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction

Ragancokova¹,

Rocca²,

Oonk³

et al. 2014

J. Clin. Invest.

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The olfactory bulb (OB) receives odor information from the olfactory epithelium and relays this to the olfactory cortex. Using a mouse model, we found that development and maturation of OB interneurons depends on the zinc finger homeodomain factor teashirt zinc finger family member 1 (TSHZ1). In mice lacking TSHZ1, neuroblasts exhibited a normal tangential migration to the OB; however, upon arrival to the OB, the neuroblasts were distributed aberrantly within the radial dimension, and many immature neuroblasts failed to exit the rostral migratory stream. Conditional deletion of Tshz1 in mice resulted in OB hypoplasia and severe olfactory deficits. We therefore investigated olfaction in human subjects from families with congenital aural atresia that were heterozygous for TSHZ1 loss-of-function mutations. These individuals displayed hyposmia, which is characterized by impaired odor discrimination and reduced olfactory sensitivity. Microarray analysis, in situ hybridization, and ChIP revealed that TSHZ1 bound to and regulated expression of the gene encoding prokineticin receptor 2 (PROKR2), a G protein-coupled receptor essential for OB development. Mutations in PROKR2 lead to Kallmann syndrome, characterized by anosmia and hypogonadotrophic hypogonadism. Our data indicate that TSHZ1 is a key regulator of mammalian OB development and function and controls the expression of molecules involved in human Kallmann syndrome.

show abstract

Section: Discussionsupporting

confidence: 53%

TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction

Ragancokova¹,

Rocca²,

Oonk³

et al. 2014

J. Clin. Invest.

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show abstract

“…Several studies have underlined a decrease in olfactory sensitivity in patients suffering from major depression [21,22,23]. However, only 18% of patients included in the present study were diagnosed as depressive.…”

Section: Discussionmentioning

confidence: 63%

Olfactory Dysfunction in Multiple Sclerosis: Evidence of a Decrease in Different Aspects of Olfactory Function

et al. 2012

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Background/Aims: Numerous authors have described olfactory dysfunction in multiple sclerosis (MS) in recent years. The aim of this study was to specify the aspects of olfactory perception that are most affected and to identify any correlations with clinical, anatomical and functional data. Methods: 50 patients with remitting or secondary progressive MS were included. Personal data were collected (medical history, characteristics of their disease, depression and disability scores and number of lesions on cerebral imaging). An olfactory test (Sniffin Sticks®) was used to evaluate subjects’ olfactory function. Results: The odor detection threshold is the most sensitive marker, with 40% of patients presenting hyposmia. The ability to identify odors is affected later on, and is inversely correlated with the level of disability. Conclusion: Our results confirm that several aspects of olfactory function are altered in MS, particularly those aspects requiring greater cognitive involvement, such as discrimination and identification of odors.

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“…Deprivation of neurogenesis in the human olfactory bulb has been implicated in several neurodegenerative diseases that compromise olfaction and can lead to anosmia (Turetsky et al 2000;Höglinger et al 2004;Hansson et al 2010;Negoias et al 2010;Winner et al 2011). However, the limited or absent olfactory bulb neurogenesis makes it unlikely that the anosmia is a consequence of reduced adult olfactory bulb neurogenesis.…”

Section: Olfactory Bulbmentioning

confidence: 99%

Adult Neurogenesis in Humans

Bergmann

Spalding

Frisén

2015

Cold Spring Harb Perspect Biol

217

167

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Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression

Cited by 258 publications

References 58 publications

TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction

TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction

Olfactory Dysfunction in Multiple Sclerosis: Evidence of a Decrease in Different Aspects of Olfactory Function

Adult Neurogenesis in Humans

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