Reduced Myc overexpression and normal B-cell differentiation mediate resistance to avian leukosis virus lymphomagenesis

Parghi, Sean S; Brandvold, Kimberly A; Bowers, Sandra J; Neiman, Paul E.; Ruddell, Alanna

doi:10.1038/sj.onc.1207577

Cited by 4 publications

(1 citation statement)

References 31 publications

(27 reference statements)

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“…The commercial broiler breeder chickens appear to be resistant to tumor development since they were susceptible to ALV-E infection, as evidenced by the presence of the ALV-E receptor TVB*S1/*S1 , and they were viremia tolerant following infection at embryonation. Parghi et al (66) identified that in ALV-resistant chickens, ALV LTR-enhanced c- myc gene expression is reduced, resulting in normal B-cell differentiation, normal follicle development, and posthatch bursal emigration in resistant transformed bursa follicles. We did not analyze bursa tissue from the commercial broiler breeder chickens to determine the level of gene transcription in transformed bursa follicles.…”

Section: Discussionmentioning

confidence: 99%

Endogenous Avian Leukosis Virus in Combination with Serotype 2 Marek's Disease Virus Significantly Boosted the Incidence of Lymphoid Leukosis-Like Bursal Lymphomas in Susceptible Chickens

Mays

Black-Pyrkosz

Mansour

et al. 2019

J Virol

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Lymphoid leukosis (LL)-like lymphoma is a low-incidence yet costly and poorly understood disease of domestic chickens. The observed unique characteristics of LL-like lymphomas are that the incidence of the disease is chicken line dependent; pathologically, it appeared to mimic avian leukosis but is free of exogenous ALV infection; inoculation of the nonpathogenic ALV-E or MDV-2 (SB-1) boosts the incidence of the disease; and inoculation of both the nonpathogenic ALV-E and SB-1 escalates it to much higher levels. This study was designed to test the impact of two new ALV-E isolates, recently derived from commercial broiler breeder flocks, in combination with the nonpathogenic SB-1 on LL-like lymphoma incidences in both an experimental egg layer line of chickens and a commercial broiler breeder line of chickens under a controlled condition. Data from this study provided an additional piece of experimental evidence on the potency of nonpathogenic ALV-E, MDV-2, and ALV-E plus MDV-2 in boosting the incidence of LL-like lymphomas in susceptible chickens. This study also generated the first piece of genomic evidence that suggests host transcriptomic variation plays an important role in modulating LL-like lymphoma formation.

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Section: Discussionmentioning

confidence: 99%