Reduced Maternal Erythrocyte Long Chain Polyunsaturated Fatty Acids Exist in Early Pregnancy in Preeclampsia

Wadhwani, Nisha; Narang, Ankita; Mehendale, Savita; Wagh, Girija; Gupte, Sanjay; Joshi, Sadhana

doi:10.1007/s11745-015-4098-5

Cited by 23 publications

(12 citation statements)

References 65 publications

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“…To the best of our knowledge, there are no published follow-up data from children born to mothers with preeclampsia in LMICs. Previous studies carried out in our department have demonstrated higher maternal homocysteine, oxidative stress, altered placental angiogenesis and disturbed fatty acid metabolism in women with preeclampsia [27,28,29]. We have also reported altered placental global and gene specific methylation patterns in angiogenic factors in preeclampsia [30].…”

Section: Introductionsupporting

confidence: 69%

Association of preeclampsia with anthropometric measures and blood pressure in Indian children

et al. 2020

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Background and objective Birth weight and post-natal growth are important predictors of adult health. Preeclampsia (PE) is associated with low birth weight and may have long term effects on the health of the children. The current study aims to compare anthropometry and blood pressure between children of mothers with and without PE in an Indian cohort. Methods We studied children born to women with (PE; n = 211) and without preeclampsia (non-PE; n = 470) at Bharati Hospital, Pune, India. Anthropometry and blood pressure were measured in children at 3-7 years of age. Weight and height Z-scores were calculated using the WHO 2006 growth reference. Independent t-tests were used to compare means between the two groups, and associations between preeclampsia and child outcomes were analyzed using multiple linear regression, adjusting for potential confounders. Results Weight and height Z-scores (p = 0.04 and 0.008), and subscapular skinfold thickness (p = 0.03) were higher among children of PE compared with children of non-PE mothers. Systolic blood pressure was also higher in children of PE mothers (1.70 mmHg [95% CI 0.05, 2.90] p = 0.006). BMI and diastolic blood pressure did not differ between groups. In regression models adjusted for newborn weight and gestational age, current age and sex, and maternal height, BMI and socioeconomic status, children of PE mothers had higher weight Z-score (0.27 SD [95%CI 0.06, 0.48] p = 0.01), height Z-score (0.28 SD [95%CI 0.09, 0.47] p = 0.005), and subscapular skinfold thickness (0.38 mm [95%CI 0.00, 0.76] p = 0.049). A trend for higher systolic blood pressure (1.59 mmHg [95%CI-0.02, 3.20] p = 0.053) in the children PLOS ONE

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Section: Introductionsupporting

confidence: 69%

Association of preeclampsia with anthropometric measures and blood pressure in Indian children

et al. 2020

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“…Several maternal characteristics, including gestational age, socioeconomic status, education, smoking and supplement use, have already been shown to affect fatty acid levels [ 63 , 77 ]. In our study, nationality, smoking status, physical activity and DHA supplement intake were found to affect several erythrocyte fatty acid species.…”

Section: Discussionmentioning

confidence: 99%

Low omega-3 index values and monounsaturated fatty acid levels in early pregnancy: an analysis of maternal erythrocytes fatty acids

et al. 2018

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BackgroundIt is unanimously recognized that the maternal nutritional status at the pregnancy onset influence both short-term and long-term health of the mother and offspring. Among several nutrients, LCPUFA, particularly from the omega-3 family, are of utmost importance. This study was carried out to determine fatty acids profile of maternal erythrocyte membranes in early pregnancy and to identify potential determinants impacting on this status.MethodsA cohort of 122 healthy women with a singleton pregnancy was included. Fatty acids were analyzed using gas chromatography. Because of the lack of cutoff values, reference ranges were used to determine fatty acids categories.ResultsOf concern, our data revealed low monounsaturated and long-chain omega-3 fatty acid status in most participants. More than 75% of Belgian pregnant women exhibited Pal, AO and EPA levels as well as IOM3 values below the laboratory reference ranges. Higher DHA concentrations and IOM3 values were found among foreign-nationality participants, non-smokers and physically active women. With regard to dietary factors, omega-3 supplements and diet seem to be complementary since DHA from supplements (but not from diet) and EPA from diet (but not from supplements) were found to be associated with higher concentrations of DHA and EPA, respectively.ConclusionsOur study presents evidence demonstrating that the fatty acid status of most early pregnant women is far from being optimal based on the admitted general reference values. Clinicians should be advice to carefully evaluate and improve this status to guarantee the best possible outcome for both the mother and the baby.Electronic supplementary materialThe online version of this article (10.1186/s12944-018-0716-6) contains supplementary material, which is available to authorized users.

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“…Our earlier preliminary study on erythrocyte fatty acid levels in women with preeclampsia ( n = 58) and normotensive controls ( n = 137) at 16–18 weeks of gestation showed a mean difference of 0.3 and standard deviation of 0.8 [49]. We aim to study 100 women with preeclampsia and 200 normotensive women, which will give 87% power to detect a difference of the same magnitude when alpha is kept at 0.05.…”

Section: Methodsmentioning

confidence: 99%

The REVAMP study: research exploring various aspects and mechanisms in preeclampsia: study protocol

Wadhwani

Sundrani

Wagh

et al. 2019

BMC Pregnancy Childbirth

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Background Preeclampsia is a major cause of maternal, fetal and neonatal morbidity and mortality, particularly in developing countries. Considering the burden of preeclampsia and its associated complications, it is important to understand the underlying risk factors and mechanisms involved in its etiology. There is considerable interest in the potential for dietary long chain polyunsaturated fatty acids (LCPUFA) as a therapeutic intervention to prevent preeclampsia, as they are involved in angiogenesis, oxidative stress, and inflammatory pathways. Methods The REVAMP study (Research Exploring Various Aspects and Mechanisms in Preeclampsia) follows a cohort of pregnant women from early pregnancy until delivery to examine longitudinally the associations of maternal LCPUFA with clinical outcome in preeclampsia. A multisite centre for advanced research was established and pregnant women coming to Bharati hospital and Gupte hospital, Pune, India for their first antenatal visit are recruited and followed up at 11–14 weeks, 18–22 weeks, 26–28 weeks, and at delivery. Their personal, obstetric, clinical, and family history are recorded. Anthropometric measures (height, weight), food frequency questionnaire (FFQ), physical activity, socioeconomic status, fetal ultrasonography, and color Doppler measures are recorded at different time points across gestation. Maternal blood at all time points, cord blood, and placenta at delivery are collected, processed and stored at − 80 °C. The children’s anthropometry is assessed serially up to the age of 2 years, when their neurodevelopmental scores will be assessed. Discussion This study will help in early identification of pregnant women who are at risk of developing preeclampsia. The prospective design of the study for the first time will establish the role of LCPUFA in understanding the underlying biochemical and molecular mechanisms involved in preeclampsia and their association with developmental programming in children.

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Reduced Maternal Erythrocyte Long Chain Polyunsaturated Fatty Acids Exist in Early Pregnancy in Preeclampsia

Cited by 23 publications

References 65 publications

Association of preeclampsia with anthropometric measures and blood pressure in Indian children

Association of preeclampsia with anthropometric measures and blood pressure in Indian children

Low omega-3 index values and monounsaturated fatty acid levels in early pregnancy: an analysis of maternal erythrocytes fatty acids

The REVAMP study: research exploring various aspects and mechanisms in preeclampsia: study protocol

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