BackgroundIt is unanimously recognized that the maternal nutritional status at the pregnancy onset influence both short-term and long-term health of the mother and offspring. Among several nutrients, LCPUFA, particularly from the omega-3 family, are of utmost importance. This study was carried out to determine fatty acids profile of maternal erythrocyte membranes in early pregnancy and to identify potential determinants impacting on this status.MethodsA cohort of 122 healthy women with a singleton pregnancy was included. Fatty acids were analyzed using gas chromatography. Because of the lack of cutoff values, reference ranges were used to determine fatty acids categories.ResultsOf concern, our data revealed low monounsaturated and long-chain omega-3 fatty acid status in most participants. More than 75% of Belgian pregnant women exhibited Pal, AO and EPA levels as well as IOM3 values below the laboratory reference ranges. Higher DHA concentrations and IOM3 values were found among foreign-nationality participants, non-smokers and physically active women. With regard to dietary factors, omega-3 supplements and diet seem to be complementary since DHA from supplements (but not from diet) and EPA from diet (but not from supplements) were found to be associated with higher concentrations of DHA and EPA, respectively.ConclusionsOur study presents evidence demonstrating that the fatty acid status of most early pregnant women is far from being optimal based on the admitted general reference values. Clinicians should be advice to carefully evaluate and improve this status to guarantee the best possible outcome for both the mother and the baby.Electronic supplementary materialThe online version of this article (10.1186/s12944-018-0716-6) contains supplementary material, which is available to authorized users.

Objectiven-3 PUFA during pregnancy have been subject to intense research interest, but also much controversy, creating a situation of confusion among patients and health-care providers. The present study was carried out to explore knowledge, attitude and practices regardingn-3 PUFA in two independent populations of pregnant women and gynaecologists–obstetricians in Belgium and to assess the relationship between the pregnant women’s attributes and theirn-3 PUFA status measured by the omega-3 index.DesignCross-sectional study. Knowledge, attitude and practices were collected by self-administered questionnaires while laboratory data were available for each pregnant woman.SettingDuring the first antenatal hospital appointment (for the pregnant women) and by email (for the gynaecologists–obstetricians).ParticipantsWomen in early pregnancy (n122) and gynaecologists–obstetricians (n67).ResultsMarked discrepancies in perception were evidenced between the pregnant women and health-care providers. While 82 % of the women attached high importance ton-3 PUFA during pregnancy, only a third of the gynaecologists–obstetricians did. About 35 % of the women declared paying particular attention to their consumption ofn-3 PUFA. After adjusting for sociodemographic characteristics, these positive dietary practices were significantly associated with higher omega-3 index (P=0·04). Overall, 43·3 % of professionals did not provide any information aboutn-3 PUFA to their pregnant patients and 46·3 % did not take any preventive actions.ConclusionsEvidence-based guidelines, refreshment training and communication tools are needed to improve awareness and clinical practices among caregivers regardingn-3 PUFA to benefit both mothers and their children.

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