Reduced Lymphatic Reserve in Heart Failure With Preserved Ejection Fraction

Rossitto, Giacomo; Mary, Sheon; McAllister, Christine; Neves, Karla B; Haddow, Laura; Rocchiccioli, J. Paul; Lang, Ninian N.; Murphy, Clare; Touyz, Rhian M.; Petrie, Mark C.; Delles, Christian

doi:10.1016/j.jacc.2020.10.022

Cited by 51 publications

(50 citation statements)

References 41 publications

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“…A recent study by Rossitto et al addressed for the first time, the concern of a reduced lymphatic reserve in patients with acquired heart disease. They showed in skin biopsies from patients with heart failure but preserved ejection fraction that the peripheral lymphatic vessels exhibited structural and molecular alterations by dilatation of the lymphatic vessels and reduced expression of markers driving development and dynamic maintenance of lymphatic vessels and valves (Rossitto et al, 2020). Our results support these structural and molecular findings by adding that functional changes are also present in the peripheral lymphatics of patients with a heart condition.…”

Section: Morphological Changes May Be Linked To the Depressed Functional Reserve Capacitysupporting

confidence: 84%

Functional lymphatic reserve capacity is depressed in patients with a Fontan circulation

et al. 2021

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Section: Morphological Changes May Be Linked To the Depressed Functional Reserve Capacitysupporting

confidence: 84%

Functional lymphatic reserve capacity is depressed in patients with a Fontan circulation

et al. 2021

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“…Fourth, interstitial space potentially contributes to fluid accumulation and the regulation of vascular volume from the outside space [ 56 , 65 – 68 , 161 , 162 ]. In particular, dermal interstitial space is reported to have an extensive depot of water-independent Na + storage, a capability of local regulatory mechanisms entailing glycosaminoglycans as the putative binding site, a buffering system for tonicity-dependent modulation via the skin lymphatic system, and a property that its disruption defines the hypertensive phenotype [ 163 – 166 ]. The extent of the contribution of electrolyte chloride to body fluid dynamics in the dermal interstitial space, however, is not known.…”

Section: Future Perspectivesmentioning

confidence: 99%

Chloride in Heart Failure Syndrome: Its Pathophysiologic Role and Therapeutic Implication

Kataoka

2021

Cardiol Ther

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Until recently, most studies of heart failure (HF) focused on body fluid dynamics through control of the sodium and water balance in the body. Chloride has remained largely ignored in the medical literature, and in clinical practice, chloride is generally considered as an afterthought to the better-known electrolytes of sodium and potassium. In recent years, however, the important role of chloride in the distribution of body fluid has emerged in the field of HF pathophysiology. Investigation of HF pathophysiology according to the dynamics of serum chloride is rational considering that chloride is an established key electrolyte for tubulo-glomerular feedback in the kidney and a possible regulatory electrolyte for body fluid distribution. The present review provides a historical overview of HF pathophysiology, followed by descriptions of the recent attention to the electrolyte chloride in the cardiovascular field, the known role of chloride in the human body, and recent new findings regarding the role of chloride leading to the proposed 'chloride theory' hypothesis in HF pathophysiology. Next, vascular and organ congestion in HF is discussed, and finally, a new classification and potential therapeutic strategy are proposed according to the 'chloride theory'.

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“…Recent discoveries found out the association between cardiac injury and impaired lymphangiogenesis. Lymphatic endothelial markers were reduced in human failing heart, and lymphatic reserve was reduced in patients with heart failure with preserved ejection fraction 3‐5 . In patients with coronary artery disease, vascular endothelial growth factor C/D (VEGFC/D) was verified to be predictors of mortality 6 .…”

Section: Introductionmentioning

confidence: 99%

“…Lymphatic endothelial markers were reduced in human failing heart, and lymphatic reserve was reduced in patients with heart failure with preserved ejection fraction. 3 , 4 , 5 In patients with coronary artery disease, vascular endothelial growth factor C/D (VEGFC/D) was verified to be predictors of mortality. 6 Therapeutic VEGFCc156s treatment improved cardiac lymphatic vascular function and alleviated Ang II‐induced cardiac fibrosis and dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Sirtuin 3 deficiency aggravates angiotensin II‐induced hypertensive cardiac injury by the impairment of lymphangiogenesis

Zhang¹,

Li²,

Suo³

et al. 2021

J Cellular Molecular Medi

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Lymphangiogenesis is possibly capable of attenuating hypertension‐induced cardiac injury. Sirtuin 3 (SIRT3) is an effective mitochondrial deacetylase that has the potential to modulate this process; however, its role in hypertension‐induced cardiac lymphangiogenesis to date has not been investigated. Our experiments were performed on 8‐week‐old wild‐type (WT), SIRT3 knockout (SIRT3‐KO) and SIRT3 overexpression (SIRT3‐LV) mice infused with angiotensin II (Ang II) (1000 ng/kg per minute) or saline for 28 days. After Ang II infusion, SIRT3‐KO mice developed a more severe cardiac remodelling, less lymphatic capillaries and lower expression of lymphatic marker when compared to wild‐type mice. In comparison, SIRT3‐LV restored lymphangiogenesis and attenuated cardiac injury. Furthermore, lymphatic endothelial cells (LECs) exposed to Ang II in vitro exhibited decreased migration and proliferation. Silencing SIRT3 induced functional decrease in LECs, while SIRT3 overexpression LECs facilitated. Moreover, SIRT3 may up‐regulate lymphangiogenesis by affecting vascular endothelial growth factor receptor 3 (VEGFR3) and ERK pathway. These findings suggest that SIRT3 could promote lymphangiogenesis and attenuate hypertensive cardiac injury.

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Reduced Lymphatic Reserve in Heart Failure With Preserved Ejection Fraction

Cited by 51 publications

References 41 publications

Functional lymphatic reserve capacity is depressed in patients with a Fontan circulation

Functional lymphatic reserve capacity is depressed in patients with a Fontan circulation

Chloride in Heart Failure Syndrome: Its Pathophysiologic Role and Therapeutic Implication

Sirtuin 3 deficiency aggravates angiotensin II‐induced hypertensive cardiac injury by the impairment of lymphangiogenesis

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