Reduced levels of microsatellite variability on the neo-Y chromosome of Drosophila miranda

Bachtrog, Doris; Charlesworth, Brian

doi:10.1016/s0960-9822(00)00656-4

Cited by 50 publications

(23 citation statements)

References 49 publications

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“…Genomic regions with reduced rates of crossing-over, and likely overall recombination, show reduced neutral y in many different eukaryotic genomes (Aguadé et al, 1989;Stephan andLangley, 1989, 1998;Berry et al, 1991;Begun and Aquadro, 1992;Martin-Campos et al, 1992;Langley et al, 1993;Aguadé and Langley, 1994;Stephan, 1994;Aquadro et al, 1994;Moriyama and Powell, 1996;Nachman, 1997;Dvorak et al, 1998;Kraft et al, 1998;Nachman et al, 1998;Zurovcova and Eanes, 1999;Bachtrog and Charlesworth, 2000;Przeworski et al, 2000;Andolfatto and Przeworski, 2001;Baudry et al, 2001;Jensen et al, 2002;Wang et al, 2002;Cutter and Payseur, 2003). Mitochondrial genomes, which lack recombination in many species, also show reduced level of polymorphisms (Weinreich and Rand, 2000).…”

Section: Direct and Indirect Evidence Of Hr In Eukaryotesmentioning

confidence: 99%

The Hill–Robertson effect: evolutionary consequences of weak selection and linkage in finite populations

2007

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The 'Hill-Robertson (HR) effect' describes that linkage between sites under selection will reduce the overall effectiveness of selection in finite populations. Here we discuss the major concepts associated with the HR effect and present results of computer simulations focusing on the linkage effects generated by multiple sites under weak selection. Most models of linkage and selection forecast differences in effectiveness of selection between chromosomes or chromosomal regions involving a number of genes. The abundance and physical clustering of weakly selected mutations across genomes, however, justify the investigation of HR effects at a very local level and we pay particular attention to linkage effects among selected sites of the same gene. Overall, HR effects caused by weakly selected mutations predict differences in effectiveness of selection between genes that differ in exon-intron structures and across genes. Under this scenario, introns might play an advantageous role reducing intragenic HR effects. Finally, we summarize observations that are consistent with local HR effects in Drosophila, discuss potential consequences on population genetic studies and suggest future lines of research.

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Section: Direct and Indirect Evidence Of Hr In Eukaryotesmentioning

confidence: 99%

The Hill–Robertson effect: evolutionary consequences of weak selection and linkage in finite populations

2007

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“…First, the evolutionary history of the Y chromosome would be shaped by selective sweeps; the accretion of each new Y-linked gene is accompanied by fixation of a single Y chromosome (and there may be additional sweeps caused by the fine-tuning of the genes to male fitness). These selective sweeps span the entire chromosome (there is no recombination in the Y) and may help to explain the low nucleotide diversity of the Drosophila Y chromosome (33,34). Second, the genic content of the Y chromosome would be fluid and may differ among Drosophilid species.…”

Section: Function Of the Y Genes And Their Correspondence With The Fementioning

confidence: 99%

Identification of five new genes on the Y chromosome of Drosophila melanogaster

Carvalho

Dobo

Vibranovski

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

182

183

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The heterochromatic state of the Drosophila Y chromosome has made the cloning and identification of Y-linked genes a challenging process. Here, we report application of a procedure to identify Y-linked gene fragments from the unmapped residue of the whole genome sequencing effort. Previously identified Y-linked genes appear in sequenced scaffolds as individual exons, apparently because many introns have become heterochromatic, growing to enormous size and becoming virtually unclonable. A TBLASTN search using all known proteins as query sequences, tested against a blastable database of the unmapped fragments, produced a number of matches consistent with this scenario. Reverse transcription-PCR and genetic methods were used to confirm those that are expressed, Y-linked genes. The five genes reported here include three protein phosphatases (Pp1-Y1, Pp1-Y2, and PPr-Y), an occludin-related gene (ORY), and a coiled-coils gene (CCY). This brings the total to nine protein-coding genes identified on the Drosophila Y chromosome. ORY and CCY may correspond, respectively, to the fertility factors ks-1 and ks-2, whereas the three protein phosphatases represent novel genes. There remains a strong functional coherence to male function among the genes on the Drosophila Y chromosome.

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“…For example, it has been postulated recently, that the human Y chromosome is the result of at least four inversions that prevented recombination over large regions of the X and Y (Lahn & Page, 1999). The Y chromosome of the plant Silene latifolia, and the neo-Y chromosome of Drosophila miranda, which results from a fusion between a chromosome arm and the old Y chromosome, are much more recent than this (Filatov et al, 1999 ;Bachtrog & Charlesworth, 2000 ;Yi & Charlesworth, 2000). The same principles that apply to a primeval non-recombining Y chromosome also apply to a neo-Y chromosome of Drosophila.…”

Section: (Iii) Y and Neo-y Chromosomesmentioning

confidence: 99%

The speed of Muller's ratchet with background selection, and the degeneration of Y chromosomes

Gordo

Charlesworth

2001

Genet. Res.

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The rate of accumulation of deleterious mutations by Muller's ratchet is investigated in large asexual haploid populations, for a range of parameters with potential biological relevance. The rate of this process is studied by considering a very simple model in which mutations can have two types of effect : either strongly deleterious or mildly deleterious. It is shown that the rate of accumulation of mildly deleterious mutations can be greatly increased by the presence of strongly deleterious mutations, and that this can be predicted from the associated reduction in effective population size (the background selection effect). We also examine the rate of the ratchet when there are two classes of mutation of similar but unequal effects on fitness. The accuracy of analytical approximations for the rate of this process is analysed. Its possible role in causing the degeneration of Y and neo-Y chromosomes is discussed in the light of our present knowledge of deleterious mutation rates and selection coefficients.

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Reduced levels of microsatellite variability on the neo-Y chromosome of Drosophila miranda

Cited by 50 publications

References 49 publications

The Hill–Robertson effect: evolutionary consequences of weak selection and linkage in finite populations

The Hill–Robertson effect: evolutionary consequences of weak selection and linkage in finite populations

Identification of five new genes on the Y chromosome of Drosophila melanogaster

The speed of Muller's ratchet with background selection, and the degeneration of Y chromosomes

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