2001
DOI: 10.1017/s0016672301005213
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The speed of Muller's ratchet with background selection, and the degeneration of Y chromosomes

Abstract: The rate of accumulation of deleterious mutations by Muller's ratchet is investigated in large asexual haploid populations, for a range of parameters with potential biological relevance. The rate of this process is studied by considering a very simple model in which mutations can have two types of effect : either strongly deleterious or mildly deleterious. It is shown that the rate of accumulation of mildly deleterious mutations can be greatly increased by the presence of strongly deleterious mutations, and th… Show more

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Cited by 77 publications
(77 citation statements)
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References 58 publications
(70 reference statements)
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“…With the parameter combinations that I tested, the effect can be substantial, accelerating the ratchet by a factor of up to 10 when there are twice as many BS loci as focal loci. Results of a similar order of magnitude have been reported in a previous theoretical study of the effect of background selection on the rate of Muller's ratchet in an asexual haploid population (Gordo and Charlesworth 2001).…”
Section: Resultssupporting
confidence: 84%
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“…With the parameter combinations that I tested, the effect can be substantial, accelerating the ratchet by a factor of up to 10 when there are twice as many BS loci as focal loci. Results of a similar order of magnitude have been reported in a previous theoretical study of the effect of background selection on the rate of Muller's ratchet in an asexual haploid population (Gordo and Charlesworth 2001).…”
Section: Resultssupporting
confidence: 84%
“…What is the effect of background selection on the speed of Muller's ratchet? It has been demonstrated previously that background selection can accelerate the ratchet in asexual haploid populations (Gordo and Charlesworth 2001), and I confirm this effect for the case of sexual diploid populations. 4.…”
supporting
confidence: 81%
“…recombination, back mutations or advantageous mutations). Indeed Charlesworth et al (1993b), has explored related scenarios with low levels of recombination under the label 'mutation accumulation' and has also used the classical theory of MR without recombination to quantify processes that can degenerate Y-chromosomes (Charlesworth 1978;Charlesworth & Charlesworth 2000;Gordo & Charlesworth 2001). If selection coefficients are further reduced with all else being equal, mutations will accumulate faster, eventually switching from the slow regime to the 'fast regime', where mutation accumulation is the norm rather than the rare exception.…”
Section: Theories On the Population Genetics Of Mutationsmentioning
confidence: 99%
“…U, s, r e , see table 1) are such that the expected critical number of optimal genotypes falls below one and any move of the population towards equilibrium will also bring the best existing genotype closer to extinction or push it over the edge. While the resulting mutation accumulation is still a random process, it is now deterministically unavoidable and hence it has also been called 'quasi-deterministic' (Gordo & Charlesworth 2001). This regime was first described explicitly in the context of the classical theory of MR (Gessler 1995) and subsequently in settings that also allow for advantageous mutations (Desai & Fisher 2007;Rouzine et al 2008).…”
Section: Theories On the Population Genetics Of Mutationsmentioning
confidence: 99%
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