Reduced Level of Sex-Specific Antigen (H-Y Antigen) on Lymphocytes in Some Patients with Bilateral Cryptorchidism

Fedder, Jens; Hansen, Lars; Hjort, T

doi:10.3109/01485018908986753

Cited by 3 publications

(1 citation statement)

References 18 publications

(10 reference statements)

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“…The H-Y antigen, also called sex-specific or male-specific antigen, was suggested to play a key role in testicular differentiation [53][54][55][56] and found to be associated with deficient testicular differentiation [57]. Interestingly, we found a girl with the 46,XY karyotype to be positive for a serologically detectable H-Y antigen but negative for a H-Y antigen detected by transplantation [58,59].…”

Section: H-y Antigen In Swordtailsmentioning

confidence: 95%

Sex Determination and Male Differentiation in Southern Swordtail Fishes: Evaluation from an Evolutionary Perspective

Fedder

2023

Fishes

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Southern swordtail fishes, which belong to the viviparous teleosts called Xiphophorus, are unique models for studies of evolution of sex chromosomes. Monofactorial sex-determining systems, with either the male or the female being the heterogametic sex, as well as sex determination involving more than two sex chromosomes, are found in swordtails and related species. Some swordtail species seem to have originated by crossing between two closely related species. Although the sword has disappeared in many Xiphophorus species during evolution, females of non-sworded species still prefer sworded males, demonstrating a discrepancy between natural and sexual selection. Natural sex change has not been documented sufficiently convincingly in swordtails, but, at least in some subspecies, two or more male phenotypes exist. In a laboratory experiment performed for over 30 years, it has been observed that sex-determining genes may be translocated from one chromosome to another in hybrids of these evolutionary young species. While the factors suggested to play central roles in sex determination and differentiation, e.g., Dmrt1 and AMH, are highly conserved during evolution, several master determining factors have been detected in teleosts. Endocrine-induced sex reversal has been demonstrated in the guppy Poecilia reticulata, another viviparous fish. In swordtails (X. helleri), endocrine disruptors such as nonylphenol and bisphenol A may cause testis cell degeneration and the inhibition of spermatogenesis. Furthermore, swordtails are very easy to breed in freshwater aquaria and, therefore, may be good models for studying the factors influencing sex determination and male differentiation.

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Section: H-y Antigen In Swordtailsmentioning

confidence: 95%

Sex Determination and Male Differentiation in Southern Swordtail Fishes: Evaluation from an Evolutionary Perspective

Fedder

2023

Fishes

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Etiology of azoospermia in 100 consecutive nonvasectomized men

Fedder¹,

Crüger

Oestergaard

et al. 2004

Fertility and Sterility

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Effect of a Combined GnRH/HCG Therapy in Boys with Undescended Testicles: Evaluated in Relation to Testicular Localization within the First Week After Birth

Fedder

Boesen

1998

Archives of Andrology

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Among 509 boys referred with undescended testicles, 112 had true undescended testicles unilaterally and 62 bilaterally. Patients with true undescended testicles were offered hormonal treatment unless the condition was associated with hernia or previous operations. Boys less than 5 years old were primarily treated with gonadotrophin releasing hormone (GnRH), while boys more than 5 years old were primarily treated with human chorionic gonadotrophin (hCG). If the effect of the primary treatment was insufficient the other hormone was given. Testicular descent was obtained for 64% (23/36) of the intraabdominally located testicles in boys with bilaterally undescended testicles versus only 14% (3/21) in boys with unilaterally undescended testicles (p < .001). Treating 1 to 4 years old boys with GnRH resulted in descent in 16 of 95 testicles and secondary treatment with hCG yielded an additional 34, whereas secondary treatment of 5 to 13 years old boys with GnRH added only 10 descended testicles to 51 of 101 testicles. Reading the maternity records of 272 of the boys support other studies showing that testicles may reascend. Boys with endocrinological or "surgical" causes of incomplete testicular descent were relatively more likely to have had one or two undescended testicles during the first postnatal week compared with boys found to have only retractile testicles (p < .001). Treatment with hormones resulted in descent in 56% of boys whose testicles were both descended within one week after birth. Conversely, only 1 of 20 boys with unilateral testicular undescent postnatally was sufficiently treated with hormones (p < .001). The hormonal effect in boys with bilaterally undescended testicles at delivery did not differ significantly from boys with either one or none undescended testicle postnatally. In 35 of 51 boys (69%) in whom the hormonal effect was insufficient, operation revealed a "surgical cause" of the incomplete testicular descent.

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Reduced Level of Sex-Specific Antigen (H-Y Antigen) on Lymphocytes in Some Patients with Bilateral Cryptorchidism

Cited by 3 publications

References 18 publications

Sex Determination and Male Differentiation in Southern Swordtail Fishes: Evaluation from an Evolutionary Perspective

Sex Determination and Male Differentiation in Southern Swordtail Fishes: Evaluation from an Evolutionary Perspective

Etiology of azoospermia in 100 consecutive nonvasectomized men

Effect of a Combined GnRH/HCG Therapy in Boys with Undescended Testicles: Evaluated in Relation to Testicular Localization within the First Week After Birth

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