Etiology of azoospermia in 100 consecutive nonvasectomized men

Fedder, Jens; Crüger, Dorthe Gylling; Oestergaard, Birthe; Petersen, Gitte

doi:10.1016/j.fertnstert.2004.06.035

Cited by 61 publications

(66 citation statements)

References 12 publications

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“…Since 1997, we have performed an examination program as described by Fedder et al . (2004) for all men referred with azoospermia on a non‐vasectomy basis. The program was initiated in the Fertility Clinic, Horsens‐Braedstrup Hospital, and from May 2011 in an extended version carried on in the Centre of Andrology / Fertility Clinic, Odense University Hospital.…”

Section: Methodsmentioning

confidence: 99%

“…Basis hormone analyses included: FSH, LH, testosterone, TSH, and prolactin, and genetic analyses included karyotype, Y microdeletions, and CFTR mutations (Fedder et al ., 2004). Two specific sequence‐tagged sites (STSs) were used for detection of deletions in each of the AZFa, AZFb, and AZFc regions.…”

Section: Methodsmentioning

confidence: 99%

“…Following application of lidocaine, 200–400 mg, into the upper scrotum on each side of the spermatic cord, the testicular biopsy was taken either as a traditional open biopsy detaching a specimen of testicular tissue bulging out through an incision on the Tunica albuginea (Fedder et al ., 2004) or more often as one to three TruCut biopsies (Ch 14) (Fedder, 2011). The first 120 men had open biopsies, while the remaining men had TruCut biopsies.…”

Section: Methodsmentioning

confidence: 99%

“…It seems highly relevant to evaluate the prevalence of THF in a cohort of men with azoospermia, the most manifested condition of male infertility. Azoospermia has an extensive variety of etiologies (Fedder et al ., 2004). In a previous study, a probable cause of azoospermia could be identified in 78% of 100 azoospermic, consecutively included men (Fedder et al ., 2004).…”

Section: Introductionmentioning

confidence: 99%

“…Azoospermia has an extensive variety of etiologies (Fedder et al ., 2004). In a previous study, a probable cause of azoospermia could be identified in 78% of 100 azoospermic, consecutively included men (Fedder et al ., 2004). Therefore, it is relevant to look for potential associations of THF with specific subgroups of azoospermia.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of small testicular hyperechogenic foci in subgroups of 382 non‐vasectomized, azoospermic men: a retrospective cohort study

Fedder

2017

Andrology

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SummaryTesticular hyperechogenic foci (THF) are associated with Klinefelter's syndrome, cryptorchidism, infertility, and testicular germ cell neoplasia. The aims of the study were to evaluate THF in relation to etiology of azoospermia and to Sertoli cell dysfunction. The structures inside the scrotum of consecutive non‐vasectomized, azoospermic were examined by ultrasonography, and hormone (FSH, LH, testosterone, and prolactin), and genetic analyses (karyotype, Y microdeletions, and CFTR mutations) were performed. At testicular ultrasonography, patients were graduated into: pronounced THF (>7 THF per transducer field), distributed universally (uTHF) or collected in plaques (pTHF), borderline THF (bTHF; 3–7 THF per transducer field), or no THF (<3 THF per transducer field). Diagnostic testicular biopsy was taken open or with TruCut needle (14G). THF status was sufficiently described in 382 of 449 potential participants, and testicular histology was available in 300 cases. Presence of ultrasonographically detectable THF was compared to presence of testicular microlithiasis (TM) detected histologically. Sertoli cell dysfunction was investigated in a subgroup using a three‐stage immunoperoxidase technique for detection of cytokeratin‐18 (CK‐18). The prevalence of THF was 13.4%. uTHF was found in 11 men (2.9%), the pattern was bilateral in four while other four had bTHF in the other testis. pTHF was detected in eight cases (2.1%), and except for one case with Klinefelter's syndrome, pTHF was in all cases occurring unilaterally. bTHF was detected in 32 cases (8.4%), bilaterally in 17 (53%). Pronounced THF was significantly associated with testicular malignancy. CK‐18 was detected in more azoospermic men with sperm production in ≤50% seminiferous tubules than in azoospermic men with spermatogenesis in ≥90% of seminiferous tubules and normal controls (p < 0.05). Unfortunately, TM detected histologically was not detected in any patient expressing THF, and neither THF nor TM was detected in any of the patients examined for CK‐18. Sertoli cell dysfunction was not associated with testicular microlithiasis or hyperechogenic foci.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prevalence of small testicular hyperechogenic foci in subgroups of 382 non‐vasectomized, azoospermic men: a retrospective cohort study

Fedder

2017

Andrology

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Epididymal Appearance in Congenital Absence of Vas Deferens

Gokhale

Kochhar²

2020

J of Ultrasound Medicine

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Scrotal sonography was performed in the infertile males. Sonography of epididymis was performed to document its presence, appearance, echo texture and duct ectasia. The spermatic cord was examined to document the status of the vas deferens. TRUS was performed to look for distal vas. Epididymal abnormalities were universal in men with congenital bilateral absence of vas deferens, with a sensitivity of 100%. Three types of abnormal appearances were recognized ‐ a honeycomb appearance, a fine meshwork pattern of head, or complete or partial absence of epididymis. Identification of these abnormalities can be a very sensitive marker for congenital bilateral absence of vas deferens.

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5. Discussion générale à partir des résultats de l’enquête rétrospective multicentrique

Mieusset

2005

Androl.

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Etiology of azoospermia in 100 consecutive nonvasectomized men

Cited by 61 publications

References 12 publications

Prevalence of small testicular hyperechogenic foci in subgroups of 382 non‐vasectomized, azoospermic men: a retrospective cohort study

Prevalence of small testicular hyperechogenic foci in subgroups of 382 non‐vasectomized, azoospermic men: a retrospective cohort study

Epididymal Appearance in Congenital Absence of Vas Deferens

5. Discussion générale à partir des résultats de l’enquête rétrospective multicentrique

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