Reduced Iron Parameters and Cognitive Processes in Children and Adolescents with Dm1 Compared to those with Standard Parameters

Mojs, Ewa; Stanisławska–Kubiak, Maia; Wójciak, R.W.; Wojciechowska, Julita; Przewoźniak, Sabina

doi:10.1136/jim-2015-000054

Cited by 4 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A child may develop different coping mechanisms. How they (and their loved ones) will actually cope with a disease depends on both internal resources such as personality, temperament, intelligence level, stress coping strategies, emotions, behaviour when confronted with the disease, and external resources which include support from carers, doctors, nurses and psychologists [1]. A neuropsychological assessment provides information about the level of functioning of a subject in relation to expected developmental norms.…”

Section: Introductionmentioning

confidence: 99%

Neuropsychological Aspects of Children’s Somatic Disorders in Chronic Diseases: Diabetes and Short Stature in the Developmental Period

Stanisławska-Kubiak,

Wiecheć,

Majewska

et al. 2023

Biomedicines

Self Cite

View full text Add to dashboard Cite

Intellectual functioning studies carried out amongst children indicate that chronic diseases like type 1 diabetes and growth hormone deficiency (GHD), may, but do not necessarily, result in intellectual loss. Cognitive functions may decline as a child becomes older, as a disease persists over time and/or due to non-compliance with treatment recommendations or high stress levels. This study aimed to assess the cognitive functioning of children and youths with T1D and GHD-related short stature compared to healthy children. Methods: The study was carried out on 88 children with type 1 diabetes, 38 children suffering from short stature caused by (GHD), as well as a control group comprising 40 healthy children. Weschler’s tests were applied to measure intellectual and cognitive functions. Results: The results suggest that for children suffering from type 1 diabetes and short stature, their chronic childhood diseases per se do not impair cognitive development. It was observed that the higher the age of chronically ill children and the longer the disease persists, the lower their scores in individual cognitive subtests. For healthy children, age is correlated with the acquisition of particular skills and higher scores in specific subtests. Conclusions: On the basis of qualitative analysis of the cognitive functions subject to the study and close clinical observation of chronically ill children, we have been able to conclude that chronic diseases may alter cognitive functioning.

show abstract

Section: Introductionmentioning

confidence: 99%

Neuropsychological Aspects of Children’s Somatic Disorders in Chronic Diseases: Diabetes and Short Stature in the Developmental Period

Stanisławska-Kubiak,

Wiecheć,

Majewska

et al. 2023

Biomedicines

Self Cite

View full text Add to dashboard Cite

show abstract

“…1 We previously reported that functional iron deficiency (ID) is common in children with T1D. 2 Since ID in children is associated with adverse effects, such as cognitive and behavioral impairment, 3,4 it is important to assess their iron status.…”

Section: Introductionmentioning

confidence: 99%

Serum hepcidin concentrations in relation to iron status in children with type 1 diabetes

Vreugdenhil

Akkermans

Swelm

et al. 2020

Pediatric Hematology and Oncology

View full text Add to dashboard Cite

Chronic low-grade inflammation in type 1 diabetes (T1D) might increase hepcidin synthesis, possibly resulting in functional iron deficiency (FID). We hypothesized that in T1D children with FID, hepcidin concentrations are increased compared to those with normal iron status and those with absolute iron deficiency (AID). We evaluated hepcidin concentrations in T1D children in relation to iron status, and investigated whether hepcidin is useful in assessing FID. A cross-sectional study was conducted. FID was defined as elevated zinc protoporphyrin/heme ratio and/or red blood cell distribution width, and AID as low serum ferritin concentration. Post-hoc analyses with different definitions of FID were performed, using transferrin saturation and reticulocyte hemoglobin content. Serum hepcidin concentrations were measured using massspectrometry. The IRODIAB-study is registered at www.trialregister.nl (NTR4642). This study included 215 T1D children with a median age of 13.7 years (Q 1-Q 3 : 10.1-16.3). The median (Q 1-Q 3) hepcidin concentration in patients with normal iron status was 1.8 nmol/l (0.9-3.3), in AIDpatients, 0.4 nmol/l (0.4-0.4) and in FID-patients, 1.6 nmol/l (0.7-3.5). Hepcidin concentrations in FID-patients were significantly higher than in AID-patients (p < 0.001). Irrespective of FID-definition used, hepcidin concentrations did not differ between FID-patients and patients with normal iron status. This might be explained by the influence of various factors on hepcidin concentrations, and/or by differences in response of iron parameters over time. Single hepcidin measurements do not seem useful in assessing FID in T1D children. Multiple hepcidin measurements over time in future studies, however, might prove to be more useful in assessing FID in children with T1D.

show abstract

Iron status and its association with HbA1c levels in Dutch children with diabetes mellitus type 1

Akkermans¹,

Houdijk

Bakker

et al. 2018

Eur J Pediatr

View full text Add to dashboard Cite

NTR4642 What is Known: • Iron deficiency is either an absolute (depleted iron stores) or a functional (restricted iron stores due to chronic inflammation) deficiency each requiring a different therapeutic approach. • Children with diabetes mellitus type 1 may be at risk for both types of iron deficiency and this can influence their hemoglobin A1c levels although this has been little studied. What is New: • In Dutch children with diabetes mellitus type 1, functional, but not absolute iron deficiency, is common and should not be treated with iron replacement therapy. • Hemoglobin A1c levels were not associated with iron deficiency, probably due to the relatively mild deprived iron status in our patients.

show abstract

Reduced Iron Parameters and Cognitive Processes in Children and Adolescents with Dm1 Compared to those with Standard Parameters

Cited by 4 publications

References 17 publications

Neuropsychological Aspects of Children’s Somatic Disorders in Chronic Diseases: Diabetes and Short Stature in the Developmental Period

Neuropsychological Aspects of Children’s Somatic Disorders in Chronic Diseases: Diabetes and Short Stature in the Developmental Period

Serum hepcidin concentrations in relation to iron status in children with type 1 diabetes

Iron status and its association with HbA1c levels in Dutch children with diabetes mellitus type 1

Contact Info

Product

Resources

About