Reduced intra-cortical inhibition after sleep deprivation: A transcranial magnetic stimulation study

Kreuzer, Peter; Langguth, Berthold; Popp, Roland; Raster, Regina; Busch, Volker; Frank, Elmar; Hajak, Goeran; Landgrebe, Michael

doi:10.1016/j.neulet.2011.02.044

Cited by 58 publications

(43 citation statements)

References 23 publications

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“…The increased excitability induced by SRD represents a further proven of the proconvulsant role explicated by REM sleep loss. Since our results are very similar to those by Scalise et al [18] and Kreuzer et al [46] observed in totally sleep deprived healthy humans, we suggest that the cortical hyperexcitability induced by total sleep deprivation may be mainly due to the net contribution provoked by REM sleep loss.…”

Section: Discussionsupporting

confidence: 92%

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Increased cortical excitability after selective REM sleep deprivation in healthy humans: A transcranial magnetic stimulation study

et al. 2013

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a b s t r a c tBackground: REM sleep has antiepileptogenic properties whereas, its loss is known to have a proconvulsive role. However, the mechanisms underlying the proepileptogenic effects of REM sleep deprivation are yet not fully understood. The aim of our study was to evaluate the effects of selective REM sleep deprivation (SRD) on cortical excitability in healthy subjects by means of transcranial magnetic stimulation (TMS). Methods: Ten normal subjects underwent three TMS sessions: (1) in baseline condition (BL), (2) after SRD by awakening them at each REM sleep onset and (3) after non-rapid eye movement sleep awakenings (NREM-A) as control for potential non-specific effects of interruptions. The TMS investigation included two protocols: (a) the evaluation of motor evoked potentials (MEPs) and silent period (SP) parameters, recorded in response to single pulse magnetic stimulation; (b) the evaluation of the time course of intracortical motor activity tested with paired-pulse TMS applied at inter-stimulus intervals of 1-10 ms. Results: After SRD the principal finding observed using single pulse TMS was a significant reduction in the duration of SP whereas, a reduction of intracortical inhibition was found, using the paired-pulse TMS. TMS parameters did not show significant changes after NREM-A with respect to BL. Conclusions: SRD may influence cortical excitability with a reduction of inhibitory intracortical mechanisms, thus supporting the proconvulsant role of REM loss.

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Section: Discussionsupporting

confidence: 92%

“…However, an increase in cortical excitability induced by total sleep deprivation has been documented by some studies in healthy subjects [17,18,46] as well as in epileptic patients [20,21,47]. In particular, Scalise et al [18] reported a reduction of both SP duration and ICI after total sleep deprivation.…”

Section: Discussionmentioning

confidence: 99%

Increased cortical excitability after selective REM sleep deprivation in healthy humans: A transcranial magnetic stimulation study

et al. 2013

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“…Only a trend toward an increased cortical excitability was instead observed in healthy controls (Del Felice et al, 2011). Unfortunately, many conflicting views emerge when the studies on the influence of SD on TMS parameters in healthy controls are considered (Civardi et al, 2001;De Gennaro et al, 2007;Huber et al, 2013;Kreuzer et al, 2011;Manganotti et al, 2001;Placidi et al, 2013;Scalise et al, 2006).…”

Section: Experimental Studies On the Effects Of Sd On Cortical Excitamentioning

confidence: 99%

What is the role for EEG after sleep deprivation in the diagnosis of epilepsy? Issues, controversies, and future directions

Giorgi

Guida

Caciagli

et al. 2014

Neuroscience & Biobehavioral Reviews

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“…( (8,9) e a excitabilidade cortical em condições fisiológicas ou patológicas. (10) Dentre as medidas utilizadas para mensuração da excitabilidade cortical através da EMT, as usualmente eleitas são o potencial evocado motor -PEM e o limiar motor de repouso -LMR. (11) Variações na amplitude ou latência destas medidas têm sido descritas em desordens neurológicas, como epilepsia, (1) esclerose lateral amiotrófica, (12) acidente vascular cerebral (13) e distonia.…”

Section: Introductionunclassified

Influência Do Gênero, Fases Do Ciclo Menstrual E Uso De Anticoncepcional Na Excitabilidade Cortical De Indivíduos Saudáveis

Monteiro

Chagas

Mazer

et al. 2015

RPF

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ResumoIntrodução: a estimulação magnética transcraniana (EMT) é uma técnica de estimulação cortical não invasiva que vem sendo empregada na investigação da fisiopatologia de desordens neurológicas. De modo a permitir a efetividade do uso da EMT como uma ferramenta para o neurodiagnóstico, é importante investigar se fatores não relacionados com doenças podem estar associados com modificações das medidas fisiológicas avaliadas pela técnica. Objetivo: verificar se o gênero, fases do ciclo menstrual e uso de anticoncepcional influenciam nas medidas de excitabilidade cortical. Metodologia: através de um estudo transversal, 114 voluntários foram divididos nos grupos: homens; mulheres em idade reprodutiva (fase folicular e lútea) e mulheres na menopausa. A EMT foi usada para identificar o limiar motor de repouso (LMR) do músculo primeiro interósseo dorsal que serviu como indicador do nível de excitabilidade. Resultados: A ANOVA one way revelou que o LMR de mulheres na menopausa e dos homens são maiores do que a de mulheres em idade reprodutiva. Ao comparar homens com mulheres em diferentes fases do ciclo menstrual, foi visto que essa diferença só existe quando as mulheres estão em fase folicular. O teste t para amostras independentes não mostrou variações no LMR de mulheres que usa ou não anticoncepcional. Conclusão: foi constatado que a excitabilidade cortical é influenciada pela variação hormonal que ocorre em indivíduos saudáveis. O uso da variação de excitabilidade cortical como medida para neurodiagnóstico de algumas doenças devem considerar essas variações não relacionadas à doença para evitar erros de diagnóstico.Palavras chave: Excitabilidade menstrual; Gênero; Ciclo menstrual.• Artigo submetido para avaliação em 12/11/2015 e aceito para publicação em 13/11/2015 A estimulação magnética transcraniana (EMT) é uma técnica de estimulação cerebral não invasiva, indolor e segura (4,5) que permite modular e avaliar a atividade cortical. (6) Baseada no princípio de indução eletromagnética postulado por Faraday em 1838, a EMT tem sido, nas últimas três décadas, amplamente empregada na investigação da fisiologia e fisiopatologia do sistema nervoso. (7) Através INFLUENCE OF GENDER, MENSTRUAL CYCLE AND CONTRACEPTIVE USE ON CORTICAL EXCITABILITY OF HEALTHY SUBJECTS AbstractIntroduction: Transcranial Magnetic Stimulation (TMS) is a non-invasive technique of cortical stimulation that is employed to investigate the pathophysiology of neurological disorders. In order to use the TMS as tool for neurodiagnosis, it is important to investigate whether factors non-related to disease may be associated with changes in physiology assessed by technique. Objective: to verify whether gender, menstrual cycle phases and contraceptive use influence on measures of cortical excitability. Methods: By cross-sectional study, 114 healthy volunteers were divided into the following groups: men; women of reproductive age (follicular and luteal phase) and menopausal women. TMS was used to identify the resting motor threshold (rMT) of the first dorsal ...

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Reduced intra-cortical inhibition after sleep deprivation: A transcranial magnetic stimulation study

Cited by 58 publications

References 23 publications

Increased cortical excitability after selective REM sleep deprivation in healthy humans: A transcranial magnetic stimulation study

Increased cortical excitability after selective REM sleep deprivation in healthy humans: A transcranial magnetic stimulation study

What is the role for EEG after sleep deprivation in the diagnosis of epilepsy? Issues, controversies, and future directions

Influência Do Gênero, Fases Do Ciclo Menstrual E Uso De Anticoncepcional Na Excitabilidade Cortical De Indivíduos Saudáveis

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