Increased cortical excitability after selective REM sleep deprivation in healthy humans: A transcranial magnetic stimulation study

Placidi, Fabio; Zannino, Silvana; Albanese, Maria; Romigi, Andrea; Izzi, Francesca; Marciani, M. G.; Palmieri, Maria Giuseppina

doi:10.1016/j.sleep.2012.11.020

Cited by 42 publications

(31 citation statements)

References 46 publications

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“…Moreover, recently, the hypercortical excitability of sleepdeprived healthy subjects, particularly when selectively deprived of rapid eye movement sleep, was demonstrated by using transcranial magnetic stimulation (Huber et al, 2013;Placidi et al, 2013). Here, we were able to demonstrate that the hyperexcitability of IEA is related to deviations from critical dynamics, thus providing additional support to the association between critical dynamics and EIB (Shew et al, 2009;Poil et al, 2012).…”

Section: Neuronal Avalanches In Epilepsy: Integration Into the State supporting

confidence: 73%

Deviations from Critical Dynamics in Interictal Epileptiform Activity

et al. 2016

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The framework of criticality provides a unifying perspective on neuronal dynamics from in vitro cortical cultures to functioning human brains. Recent findings suggest that a healthy cortex displays critical dynamics, giving rise to scale-free spatiotemporal cascades of activity, termed neuronal avalanches. Pharmacological manipulations of the excitation-inhibition balance (EIB) in cortical cultures were previously shown to result in deviations from criticality and from the power law scaling of avalanche size distribution. To examine the sensitivity of neuronal avalanche metrics to altered EIB in humans, we focused on epilepsy, a neurological disorder characterized by hyperexcitable networks. Using magnetoencephalography, we quantitatively assessed deviations from criticality in the brain dynamics of patients with epilepsy during interictal (between-seizures) activity. Compared with healthy control subjects, epilepsy patients tended to exhibit a higher neural gain and larger avalanches, particularly during interictal epileptiform activity. Moreover, deviations from scalefree behavior were exclusively connected to brief intervals at epileptiform discharges, strengthening the association between deviations from criticality and the instantaneous changes in EIB. The avalanches collected during interictal epileptiform activity had not only a stereotypical size range but also involved particular spatial patterns of activations, as expected for periods of epileptic network dominance. Overall, the neuronal avalanche metrics provide a quantitative novel description of interictal brain activity of patients with epilepsy.

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Section: Neuronal Avalanches In Epilepsy: Integration Into the State supporting

confidence: 73%

Deviations from Critical Dynamics in Interictal Epileptiform Activity

et al. 2016

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“…Some studies report heightened cortical excitability when assessed during wakefulness or after REM sleep deprivation (relative to undisturbed sleep) [22, 23] whereas other studies reported no state-dependent changes in cortical excitability. In two separate studies [24, 25], cortical excitability and intracortical inhibition were measured at different times of day, after periods of sleep or wake, or after sleep deprivation.…”

Section: Changes In Synaptic Efficacy Across the Sleep-wake Cyclementioning

confidence: 99%

Sleep, clocks, and synaptic plasticity

Frank

Cantera

2014

Trends in Neurosciences

104

102

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Sleep is widely believed to play an essential role in synaptic plasticity. However, the precise mechanisms governing this presumptive function are largely unknown. There is also evidence for independent circadian oscillations in synaptic strength and morphology. Therefore, synaptic changes observed after sleep reflect interactions between state-dependent (e.g. wake vs. sleep) and state-independent (circadian) processes. In this article we review how sleep and biological clocks influence synaptic plasticity. We discuss these findings in the context of current plasticity-based theories of sleep function and propose a new model that integrates circadian and brain state influences on synaptic plasticity.

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“…Only a trend toward an increased cortical excitability was instead observed in healthy controls (Del Felice et al, 2011). Unfortunately, many conflicting views emerge when the studies on the influence of SD on TMS parameters in healthy controls are considered (Civardi et al, 2001;De Gennaro et al, 2007;Huber et al, 2013;Kreuzer et al, 2011;Manganotti et al, 2001;Placidi et al, 2013;Scalise et al, 2006).…”

Section: Experimental Studies On the Effects Of Sd On Cortical Excitamentioning

confidence: 99%