Reduced Insulin Sensitivity of Tenotomized Muscle: A Possible Role of Adenosine

Budohoski, L; Kozłowski, S; Dubaniewicz, Anna; Nazar, K; Kaciuba-Uściłko, H.; Newsholme, E. A.

doi:10.1055/s-2007-1012356

Horm Metab Res

1986

DOI: 10.1055/s-2007-1012356

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Reduced Insulin Sensitivity of Tenotomized Muscle: A Possible Role of Adenosine

L Budohoski¹,

S Kozłowski²,

Anna Dubaniewicz³

et al.

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Cited by 4 publications

(1 citation statement)

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“…Muscle inactivity that follows denervation or tenotomy is accompanied by reduced mitochondrial enzyme activities (1,35) and decreased skeletal muscle ability to oxidize glucose and fatty acids, leading to a decline in intramuscular high-energy phosphates (5). An inhibition of insulin-stimulated glucose transport and decreased rates of glycolysis and glycogen synthesis were also found in denervated or tenotomized muscles (8,22). These metabolic changes occur within a few hours after denervation or tenotomy in skeletal muscles of different fiber types, being the most pronounced in muscles composed predominantly of slow-twitch fibers (32,33).…”

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confidence: 99%

Lipoprotein lipase activity in skeletal muscles of the rat: effects of denervation and tenotomy

Smol

̇ernicka

Czarnowski

et al. 2001

Journal of Applied Physiology

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The effects of denervation, tenotomy, or tenotomy with simultaneous denervation on the activity of heparin-releasable and intracellular, residual lipoprotein lipase (LPL) and triacylglycerol (TG) content were examined in rat skeletal muscles. An influence of muscle electrostimulation on denervated and tenotomized muscles was also evaluated. Activity of both LPL fractions was decreased in denervated and/or tenotomized soleus and red portion of gastrocnemius muscles. It was accompanied by a slight elevation of the intracellular TG content. Electrostimulation increased activities of both fractions of LPL in red muscles from intact hindlimbs. In stimulated denervated muscles without or with simultaneous tenotomy, activity of two LPL fractions was also enhanced, but control values were reached only in denervated soleus muscle. Electrical stimulation had no pronounced effect on LPL activity in tenotomized muscles. In conclusion, denervation and/or tenotomy decreases LPL activity in red muscles, indicating reduction of the muscle potential to utilize circulating TG. Electrostimulation only partly restores the diminished LPL activity in denervated muscles, without any effect in tenotomized ones. Thus, to maintain LPL activity in resting muscle, intact innervation and tension are needed.

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mentioning

confidence: 99%

Lipoprotein lipase activity in skeletal muscles of the rat: effects of denervation and tenotomy

Smol

̇ernicka

Czarnowski

et al. 2001

Journal of Applied Physiology

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Electrical stimulation partly reverses the muscle insulin resistance caused by tenotomy

et al. 1993

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It was shown that I5-min electrical stimulation of the rat sciatic nerve greatly increases the in vitro measured sensitivity of lactate formation, glucose transport, and glycogen synthesis to insulin, impaired by previous tenotomy. The insulin sensitivity of all these processes was, however, still below that found in the stimulated intact soleus muscle. Extending the stimulation up to 30 min did not cause any further changes in insulin sensitivity either in tenotomized or in intact muscles.

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Effects of acute and chronic hindlimb suspension on sensitivity and responsiveness to insulin in the rat soleus muscle

Langfort¹,

Zernicka²,

Mayet-Sornay³

et al. 1997

Biochem. Cell Biol.

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The effects of acute (24 h) and chronic (5 weeks) hindlimb suspension on insulin-stimulated glucose utilization by the rat soleus muscle were studied in vitro. Hindlimb suspension resulted in an enhancement of basal glucose transport, lactate production, and glycogen synthesis. An increase in the sensitivity of these processes to insulin occurred as early as 24 h and persisted for 5 weeks of the muscle unloading. An increased responsiveness to insulin was found only for glucose transport after 24 h. The present data do not support the concept that the enhanced glucose utilization and improved muscle insulin sensitivity during hindlimb suspension are related to muscle atrophy, which is not observed in the early stage of muscle unweighting.

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Reduced Insulin Sensitivity of Tenotomized Muscle: A Possible Role of Adenosine

Cited by 4 publications

References 4 publications

Lipoprotein lipase activity in skeletal muscles of the rat: effects of denervation and tenotomy

Lipoprotein lipase activity in skeletal muscles of the rat: effects of denervation and tenotomy

Electrical stimulation partly reverses the muscle insulin resistance caused by tenotomy

Effects of acute and chronic hindlimb suspension on sensitivity and responsiveness to insulin in the rat soleus muscle

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