Electrical stimulation partly reverses the muscle insulin resistance caused by tenotomy

Langfort, Józef; Czarnowski, D.; Budohoski, L; Górski, Jan; Kaciuba-Uściłko, H.; Nazar, K

doi:10.1016/0014-5793(93)81159-w

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…There is evidence that muscle electrostimulation at least partly reverses some biochemical alterations caused by denervation or tenotomy, e.g., it increases glucose uptake and glucose utilization by myocytes (17,33). It was also reported that elimination of neural activity in tenotomized muscles by simultaneous denervation can limit the loss of myofibrillar ATPase and other mitochondrial oxidative enzyme activities and reduce another metabolic changes induced by tenotomy (29).…”

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Lipoprotein lipase activity in skeletal muscles of the rat: effects of denervation and tenotomy

Smol

̇ernicka

Czarnowski

et al. 2001

Journal of Applied Physiology

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The effects of denervation, tenotomy, or tenotomy with simultaneous denervation on the activity of heparin-releasable and intracellular, residual lipoprotein lipase (LPL) and triacylglycerol (TG) content were examined in rat skeletal muscles. An influence of muscle electrostimulation on denervated and tenotomized muscles was also evaluated. Activity of both LPL fractions was decreased in denervated and/or tenotomized soleus and red portion of gastrocnemius muscles. It was accompanied by a slight elevation of the intracellular TG content. Electrostimulation increased activities of both fractions of LPL in red muscles from intact hindlimbs. In stimulated denervated muscles without or with simultaneous tenotomy, activity of two LPL fractions was also enhanced, but control values were reached only in denervated soleus muscle. Electrical stimulation had no pronounced effect on LPL activity in tenotomized muscles. In conclusion, denervation and/or tenotomy decreases LPL activity in red muscles, indicating reduction of the muscle potential to utilize circulating TG. Electrostimulation only partly restores the diminished LPL activity in denervated muscles, without any effect in tenotomized ones. Thus, to maintain LPL activity in resting muscle, intact innervation and tension are needed.

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confidence: 99%

Lipoprotein lipase activity in skeletal muscles of the rat: effects of denervation and tenotomy

Smol

̇ernicka

Czarnowski

et al. 2001

Journal of Applied Physiology

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“…In this study, the results showed a decrease in plasma resistin and insulin in diabetic rats treated with electrical muscle stimulation. It has been shown that electrical stimulation increases glucose transport in skeletal muscle by GLUT-4 translocation [ 37 ] , and electrical stimulation improved glucose tolerance and insulin sensitivity [ 15 ] . In addition, 9 diabetes related genes expression changes were induced by the repetitive electrical muscle stimulation in mouse masseter [ 38 ] .…”

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Electrical Muscle Stimulation Normalizes Blood Glucose Level in Streptozotocin-induced Diabetic Rats

Lü

Meng

2013

Phys Rehab Kur Med

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▼ Background: Patients with diabetes suff er from slow-to-heal wounds, which often necessitate amputation. Electrical stimulation has been shown to reduce the healing time in such patients.Objectives: This study aimed to determine the eff ect of electrical muscle stimulation on insulin resistance, glucose absorption, and blood lipids in type 2 diabetic rat model. Methods: Diabetic rats and normal rats were treated with electrical muscle stimulation (10 Hz, 2 mA, 20 ms) for 40 days. Blood glucose, lipids, insulin and resistin were measured to evaluate antidiabetic activity of electrical stimulation. Results: Diabetic rats treated with electrical muscle stimulation resulted in a signifi cant decrease in the concentration of plasma total cholesterol and triglycerides, improved the body weight. Furthermore, electrical stimulation markedly decreased blood glucose level in the diabetic rats. The levels of plasma insulin and resistin exhibited signifi cantly lower in the diabetic rats treated with electrical stimulation than those of the model group. Extending the stimulation up to 20 min from 10 min did not cause signifi cant changes in all the measured blood biochemistry indices and body weight. Conclusions: This study showed that electrical muscle stimulation can improve adipose metabolic disturbance in the experimental type 2 diabetic rats, can eff ectively ameliorate insulin resistance and plasma glucose transport by decreasing the levels of plasma resistin.

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Glucose Utilization

Richter

1996

Comprehensive Physiology

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The sections in this article are: Molecular Basis for Glucose Transport Family of Glucose Transporters Translocation of Glucose Transporters Intrinsic Activity Fiber‐Type Specific Expression of GLUT 4 Role of Glut4 in Contraction‐Induced Skeletal Muscle Glucose Transport Signaling Mechanisms Involved in Contraction‐Induced Increase in Glucose Transport Regulation of Glucose Utilization in Vivo Glucose Supply Membrane Glucose Transport Capacity Glucose Metabolism Regulation of Glucose Utilization at Rest Regulation of Glucose Utilization During Exercise Effect of Exercise Intensity Effect of Exercise Duration Effect of Exercise Type Alternative Substrates Glucose Utilization During Exercise in Adverse Environment Humoral Regulation of Glucose Utilization During Exercise Effect of Physical Training Status Exercise in States of Altered Glucose Utilization Regulation of Glucose Utilization in the Postexercise State Membrane Glucose Transport Capacity Induced by Contraction Insulin Sensitivity

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Electrical stimulation partly reverses the muscle insulin resistance caused by tenotomy

Cited by 4 publications

References 18 publications

Lipoprotein lipase activity in skeletal muscles of the rat: effects of denervation and tenotomy

Lipoprotein lipase activity in skeletal muscles of the rat: effects of denervation and tenotomy

Electrical Muscle Stimulation Normalizes Blood Glucose Level in Streptozotocin-induced Diabetic Rats

Glucose Utilization

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