“…Alterations in cycle regime, such as the use of lower gonadotropin doses (6), GnRH antagonist protocols (7), GnRH agonist rather than hCG (8), coadministration of metformin in women with polycystic ovarian syndrome (PCOS) (9), and the use of progesterone for luteal support (10), have all been demonstrated to significantly decrease OHSS risk. Other preventive measures, such as the cryopreservation of all embryos in an attempt to minimize the risk of ''late OHSS'' (11), follicular aspiration before hCG (12,13), and the administration of intravenous albumin (1,14) or hydroxyl-ethyl starch (15), have also been reported but remain unproven. More recently, reports have suggested a role for dopamine agonists, with a significant decrease in hematologic and clinical markers of OHSS as well as significant decrease in incidence of moderate OHSS compared with placebo by virtue of an inhibition of vascular permeability via dephosphorylation of the vascular endothelial growth factor receptor (16,17).…”