Administration of Intravenous Albumin around the Time of Oocyte Retrieval Reduces Pregnancy Rate without Preventing Ovarian Hyperstimulation Syndrome: A Systematic Review and Meta-Analysis

Abstract

Background/Aim: The aim of this meta-analysis was to evaluate whether IV albumin infusion around the time of oocyte retrieval prevents ovarian hyperstimulation syndrome (OHSS) and affects the pregnancy rate. Methods: A meta-analysis of data from 9 randomized controlled trials including 1,613 women at high risk for developing OHSS in in vitro fertilization cycles was performed. Results: The combined incidence of severe OHSS was 6.0% in the IV albumin group and 7.9% in saline or no treatment groups. These rates were statistically not different (RR = 0.80, 95% CI = 0.57–1.12). Treatment with IV albumin significantly lowered the pregnancy rates (RR = 0.85, 95% CI = 0.74–0.98). Conclusions: The combined data presented in this meta-analysis do not support a benefit for IV albumin around the time of oocyte retrieval in preventing OHSS and even showed a deleterious effect on the pregnancy rate.

Albumin utilization evaluation in a major teaching hospital in Iran: Recommendations for guideline development

“…However, we evaluated the consumption patterns of albumin by reviewing a wide range of the latest existing evidence-based studies and guidelines. [12345678910111213141516232417181920]…”

“…[123456789101112131415161718192021] The appropriate and inappropriate indications are shown in Tables 1[2] and 2,[125678101222171819] respectively.…”

All Aspects of Ovarian Hyperstimulation Syndrome

“…55 Riskli hastalarda bunlarla OHSS riskinin azaldığını gösteren yeterli veri ise henüz yoktur. 56,57 Cihan ÇETİN ve ark.…”

Cross-Sectional Guidelines for Therapy with Blood Components and Plasma Derivatives: Chapter 5 Human Albumin - Revised

“…Further potential indications concern the prevention and therapy of a severe ovarian hyperstimulation syndrome [117], despite the fact that the data situation is quite controversial and that two additional systematic reviews could prove no or at most a marginal effect on the incidence rate of ovarian hyperstimulation syndrome [48,108]. Furthermore, deleterious effects (e.g.…”