Cross-Sectional Guidelines for Therapy with Blood Components and Plasma Derivatives: Chapter 5 Human Albumin - Revised

,

doi:10.1159/000446043

Cited by 31 publications

(10 citation statements)

References 112 publications

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“…Restrictive transfusion thresholds as applied in most of the analysed RCTs (Hb threshold < 8 g/dl) are comparable to those recommended by the German Medical Association in the ‘Cross-Sectional Transfusion Guidelines for Therapy with Blood Components and Plasma Derivatives' (4th revised edition) [10] which recommends transfusion during acute blood loss mandatorily only for Hb levels below 6 g/dl and between 6 and 8.0 g/dl depending on the patient's risk profile.…”

Section: Discussionmentioning

confidence: 78%

“…For patients with cardiovascular risk factors, a more liberal transfusion regimen might be advisable, whereas patients with history of stroke/TIA might benefit from a restrictive transfusion regimen. The German transfusion guidelines [10] do reflect the current scientific knowledge. No further or more restrictive recommendations are currently warranted.…”

Section: Resultsmentioning

confidence: 99%

“…In 2014, the German Medical Association (GMA) published an updated version of their cross-sectional guidelines applicable for therapy with blood components and plasma derivatives [10]. According to this GMA guideline, only haemoglobin (Hb) blood levels ≤ 6 g/dl are an absolute indication for transfusion of RBCs.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mortality, Morbidity and Related Outcomes Following Perioperative Blood Transfusion in Patients with Major Orthopaedic Surgery: A Systematic Review

Müller

Oberle

Drechsel-Bäuerle

et al. 2018

Transfus Med Hemother

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Background: Benefits and risks of liberal and restrictive transfusion regimens are under on-going controversial discussion. This systematic review aimed at assessing both regimens in terms of pre-defined outcomes with special focus on patients undergoing major orthopaedic surgery. Methods: We performed a literature search for mortality, morbidity and related outcomes following peri-operative blood transfusion in patients with major orthopaedic surgery in electronic databases. Combined outcome measure estimates were calculated within the scope of meta-analyses including randomised clinical trials comparing restrictive versus liberal blood transfusion regimens (e.g. MH risk ratio, Peto odds ratio). Results: A total of 880 publications were identified 15 of which were finally included (8 randomised clinical trials (RCTs) with 3,693 patients and 6 observational studies with 4,244,112 patients). Regarding RCTs, no significant differences were detected between the transfusion regimes for all primary outcomes (30-day mortality, thromboembolic events, stroke/transitory ischaemic attack, myocardial infarction, wound infection and pneumonia) and a secondary outcome (length of hospital stay), whereas there was a significantly reduced risk of receiving at least one red blood concentrate under a restrictive regimen. Conclusion: The results of this systematic review do not suggest an increased risk associated with either a restrictive or a liberal transfusion regimen in patients undergoing major orthopaedic surgery.

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Section: Discussionmentioning

confidence: 78%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Mortality, Morbidity and Related Outcomes Following Perioperative Blood Transfusion in Patients with Major Orthopaedic Surgery: A Systematic Review

Müller

Oberle

Drechsel-Bäuerle

et al. 2018

Transfus Med Hemother

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“…To put this in perspective, each compound is available at 5 μM concentration (50 μM total compound in each pool), while the availability of binding sites on albumin is >500 μM. 38 For human alpha-1-acid glycoprotein, the estimated plasma concentration is around 15–30 μM, 39 such that the risk of interference is larger should more than one compound in the pool bind extensively to this protein. As illustrated below, the agreement between data from different test occasions and between test sites, which in practice translates to different pools, suggest that this problem is limited but remains a consideration when interpreting data.…”

Section: Resultsmentioning

confidence: 99%

A Fully Integrated Assay Panel for Early Drug Metabolism and Pharmacokinetics Profiling

Wernevik

Bergström

Novén

et al. 2020

ASSAY and Drug Development Technologies

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Evaluation and optimization of physicochemical and metabolic properties of compounds are a crucial component of the drug development process. Continuous access to this information during the design-make-test-analysis cycle enables identification of chemical entities with suitable properties for efficient project progression. In this study, we describe an integrated and automated assay panel (DMPK Wave 1) that informs weekly on lipophilicity, solubility, human plasma protein binding, and metabolic stability in rat hepatocytes and human liver microsomes. All assays are running in 96-well format with ultraperformance liquid chromatography–mass spectrometry (MS)/MS as read-out. A streamlined overall workflow has been developed by optimizing all parts of the process, including shipping of compounds between sites, use of fit-for-purpose equipment and information systems, and technology for compound requesting, data analysis, and reporting. As a result, lead times can be achieved that well match project demands across sites independently of where compounds are synthesized. This robust screening strategy is run on a weekly basis and enables optimization of structure-activity relationships in parallel with DMPK properties to allow efficient and informed decision making.

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“…The half-life of HSA is about 19 days and its decrease production in the liver by 10–15% after 50 years of age [18] . Free albumin up to 80% is found within the interstitial spaces where it is assumed to perform the transport function for fatty acids, bilirubin, and hormones as well as for many drugs [19] . Free fatty acids (FFA), SARS coronavirus-2 (SARS-CoV-2) virions and melatonin are transported through bound albumin, as are called glycolates [18] .…”

Section: Low Human Serum Albumin Level In Non-surviving Covid-19 Patientsmentioning

confidence: 99%

Review: Roles of human serum albumin in prediction, diagnoses and treatment of COVID-19

Rabbani¹,

Ahn²

2021

International Journal of Biological Macromolecules

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The severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) keeps on destroying normal social integrity worldwide, bringing about extraordinary medical services, cultural and financial interruption. Individuals with diabetes have been demonstrated to be at higher risk of complications and even death when exposed to SARS-CoV-2. Regardless of pandemic scale infection, there is presently limited comprehension on the potential impact of SARS-CoV-2 on individuals with diabetes. Human serum albumin (HSA) is the most abundant circulating plasma protein in human serum and attracted more interest from researchers because most susceptible to non-enzymatic glycation reactions. Albumin down-regulates the expression of ACE2 that is the target receptor of COVID-19. Hypoalbuminemia, coagulopathy, and vascular disease have been connected in COVID-19 and appear to predict outcomes independent of age and morbidity. This review discusses the most recent evidence that the ACE/ACE2 ratio could influence by human serum albumin both the susceptibility of individuals to SARS-CoV-2 infection and the outcome of the COVID-19 disease.

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Cross-Sectional Guidelines for Therapy with Blood Components and Plasma Derivatives: Chapter 5 Human Albumin - Revised

Abstract: Chapter 5 ‘Human Albumin' that was suspended on January 10, 2011 has been completed and updated in the present version.

Cited by 31 publications

References 112 publications

Mortality, Morbidity and Related Outcomes Following Perioperative Blood Transfusion in Patients with Major Orthopaedic Surgery: A Systematic Review

Mortality, Morbidity and Related Outcomes Following Perioperative Blood Transfusion in Patients with Major Orthopaedic Surgery: A Systematic Review

A Fully Integrated Assay Panel for Early Drug Metabolism and Pharmacokinetics Profiling

Review: Roles of human serum albumin in prediction, diagnoses and treatment of COVID-19

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