Reduced Histamine Reaction in Atopic Dermatitis

Uehara, Masami

doi:10.1001/archderm.1982.01650160034018

Cited by 31 publications

(14 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The result is consistent with results of previous studies done on atopic dermatitis [6,23,24] . The decreased sensation of pruritus with injected histamine in psoriatic patients could be due to an increased concentration of histamine in psoriasis plaques [25] , leading to a downregulation of histamine receptors.…”

Section: Discussionsupporting

confidence: 93%

Responses to Intradermal Injections of Substance P in Psoriasis Patients with Pruritus

Amatya

Nordlind²,

Wahlgren³

2009

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Background: Various mediators have been suggested for the pathogenesis of pruritus in psoriasis. Methods: To investigate cutaneous responses of substance P in pruritic lesional and nonlesional areas of psoriasis patients and in healthy controls, substance P, saline and histamine were injected intradermally. After each injection, pruritus, flare and wheal were recorded. Results: There was no statistical difference in the latency period, duration, area under the curve and maximum intensity of pruritus evoked by substance P (10^–5 and 10^–6 mol/l) between psoriasis and healthy control skin. Substance P (10^–5 mol/l) induced a tendency to a greater intensity of pruritus in lesional compared to nonlesional psoriatic skin (p = 0.08). Histamine produced a shorter itch latency period (p < 0.05) and a lower maximum intensity of pruritus (p = 0.05) in lesional psoriasis skin than in healthy control skin. No significant difference in flare area was observed between the psoriasis patients and healthy controls. The histamine-induced wheal was smaller in psoriasis patients than in healthy individuals (p < 0.05). Conclusion: Intradermally injected substance P induced pruritus, flare and wheal in psoriasis patients. However, these responses did not differ significantly from those of the healthy controls.

show abstract

Section: Discussionsupporting

confidence: 93%

Responses to Intradermal Injections of Substance P in Psoriasis Patients with Pruritus

Amatya

Nordlind²,

Wahlgren³

2009

Skin Pharmacol Physiol

View full text Add to dashboard Cite

show abstract

“…Apparently VIP induces the release of histamine from mast cells (14) and vice versa (17). The present findings suggest the involvement of histamine in VIP-induced reactions, which is supported by previous reports of diminished responses of AE patients to direct administration of histamine (18,19) and histamine releasing substances (20,21).…”

Section: Discussionsupporting

confidence: 91%

Administration of acetylcholine and vasoactive intestinal polypeptide to atopic eczema patients

Rukwied

Heyer

1999

Experimental Dermatology

View full text Add to dashboard Cite

Responses to acetylcholine (ACh) and vasoactive intestinal polypeptide (VIP) were investigated in atopic eczema (AE) patients. To elucidate the involvement of histamine to ACh-provoked vasoreactions and sensations, we applied a selective H1-antagonist (cetirizine) 3 h prior to the ACh-administration. Solutions of acetylcholine (ACh, 0.55 M) and vasoactive intestinal polypeptide (VIP, 1.5x 10(-5) M) were injected (10 microl) intracutaneously into the volar forearm of 14 healthy subjects and 14 atopic eczema (AE) patients. The substances were applied as single stimulus as well as in combination. Sensations evoked by the stimulation were recorded using 2 visual analog scales (VAS). Vasoreactions were analyzed with the new technique of computer assisted video image analysis. With this method we measured the dynamics of the flare development and the extension of the final flare size independent of the observer's assessment. In control subjects the development and extension of the final flare size was almost similar, regardless whether ACh and VIP were applied in combination or separately. Compared to healthy controls, after injection of ACh, VIP and the combination of VIP and ACh smaller flare sizes were recorded in AE patients. After VIP was given, the control subjects reported pruritus, which was significantly augmented compared to AE patients. In contrast, controls reported a burning pain after the injection of ACh, whereas AE patients felt predominantly pruritus. Itch sensation after the combined application of VIP and ACh was significantly elevated in AE patients. Consequently, we assume that mediators of sudomotor neurons, i.e., VIP and ACh meet in AE patients apparently sensitized nociceptive primary afferents and induce exaggerated itch, pain and flare responses. When pretreated with the selective H1-antagonist cetirizine before ACh was injected, pain and erythema due to ACh was diminished in healthy controls. In contrast, cetirizine did not influence the size of erythema and the magnitude of sensation in AE patients. We conclude, that the release of histamine is not involved in ACh-induced erythema and pruritus in AE. These data provide evidence that pruritus can be elicited in atopic eczema by a cholinergic, histamine independent mechanism.

show abstract

“…One group of patients with AE suffered from an acute outbreak of been reported by several investigators (1)(2)(3)(4)(5). The reason for their disease during our study and all of them were treated as the diminished histamine-induced axon-reflex erythema could in-patients.…”

Section: Axon-reflex Function Possibly Due To a Downregulation Of C-mentioning

confidence: 62%

Histamine and cutaneous nociception: histamine-induced responses in patients with atopic eczema, psoriasis and urticaria

Heyer

Koppert²,

Martus³

et al. 1998

Acta Dermato-Venereologica

View full text Add to dashboard Cite

Having observed altered itch and flare reactions after histamine application in patients with atopic eczema, we tried to determine these reactions in patients with urticaria and psoriasis. We investigated 16 healthy non-atopic subjects, 16 atopics in an eczema-free interval, 16 with acute atopic eczema, 16 with urticaria and 16 with psoriasis. Histamine was iontophoretically applied. The resulting sensations were rated on a visual analogue scale. Flare areas were measured 6 min after stimulation. Itch ratings of urticaria and psoriasis patients did not differ significantly from controls, whereas both atopic groups, regardless of acute or symptom-free state, reported significantly reduced intensity of itching. Flares were significantly diminished in all subjects with acute skin disease (psoriasis, urticaria and atopic eczema), regardless of diagnosis. However, flares were "normal" in symptom-free atopics and were not significantly different from controls. In conclusion, all "acute" patients showed a diminished axon-reflex function, possibly due to a downregulation of C-fiber responsiveness to histamine or an increased turnover rate of inflammatory mediators. Both atopic groups reported weaker itching, suggesting altered central nervous processing of itch.

show abstract

Reduced Histamine Reaction in Atopic Dermatitis

Cited by 31 publications

References 11 publications

Responses to Intradermal Injections of Substance P in Psoriasis Patients with Pruritus

Responses to Intradermal Injections of Substance P in Psoriasis Patients with Pruritus

Administration of acetylcholine and vasoactive intestinal polypeptide to atopic eczema patients

Histamine and cutaneous nociception: histamine-induced responses in patients with atopic eczema, psoriasis and urticaria

Contact Info

Product

Resources

About