Reduced High-Density Lipoprotein in Women Aged 40-41 Using Oral Contraceptives

Arntzenius, A. C.; Gent, C.M. van; Voort, H. Van Der; Stegerhoek, C.I.; Stýblo, K

doi:10.1016/s0140-6736(78)92461-3

Cited by 67 publications

(19 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…HDL cholesterol or HDL to total cholesterol ratio also showed controversial results in dif ferent estrogen or contraceptive pill prepara tions. Most of them demonstrated a clear tendency for a decline in the lipoprotein lev els [5,6]. As HDL were proved to be anti atherogenic, the influence of hormonal prep aration on these lipoproteins became of high importance.…”

Section: Discussionmentioning

confidence: 99%

Lipid and Lipoprotein Levels following Pure Estradiol Implantation in Post-Menopausal Women

Шарф¹,

Oettinger²,

Lanir³

et al. 1985

Gynecol Obstet Invest

View full text Add to dashboard Cite

8 post-menopausal, post-oophrectomy and hysterectomy women had a 100-mg pure 17Β-estradiol pellet installed in their subcutaneous abdominal tissue. The pellet caused a marked systemic hormonal effect in these patients causing an up to 30-fold increase in plasma estradiol and a marked decrease in follicle-stimulating hormone levels. It showed a significant increase in plasma high density lipoprotein (HDL) and HDL to total cholesterol ratio levels, no change in plasma triglycerides and very low density lipoprotein levels and some decrease in total cholesterol and low density lipoprotein cholesterol concentrations. These results differ from the previously reported influence of synthetic hormonal preparations on the same plasma lipids and lipoproteins.

show abstract

Section: Discussionmentioning

confidence: 99%

Lipid and Lipoprotein Levels following Pure Estradiol Implantation in Post-Menopausal Women

Шарф¹,

Oettinger²,

Lanir³

et al. 1985

Gynecol Obstet Invest

View full text Add to dashboard Cite

show abstract

“…'-6 As PGI2 is a potent inhibitor of platelet aggregation,7 the deficiency in production of PGI2 may contribute to the high incidence of vascular disease in diabetes. The relevance of these findings in diabetic rat aortas has been challenged by reports showing no decrease in circulating 6-oxo-prostaglandin Floc (6-oxo-PGF,cx) (the stable metabolite of PGI2) in human diabetes.8 19 This suggests either that the observations in diabetic rats are not relevant to human diabetes or that regional differences in PGI2 production occur. In particular there might be differences in PGI2 production between large arteries and the microvascular circulation.…”

Section: Discussionmentioning

confidence: 99%

Influence of contraceptive pill and menstrual cycle on serum lipids and high-density lipoprotein cholesterol concentrations.

Demacker¹,

Rr²,

Stalenhoef³

et al. 1982

BMJ

View full text Add to dashboard Cite

The fluctuations of serum lipid and lipoprotein concentrations within one cycle were studied both in women using and not using oral contraceptives. High-density lipoprotein cholesterol decreased significantly from 1 47 mmol/l (57 mg/100 ml) to 1 30 mmol/l (50 mg/100 ml) during one contraceptive cycle in eight women and rose again to the initial value during the pill-free days. The mean concentration of total cholesterol also fell significantly as a result of the decrease of high-density lipoprotein cholesterol and of a not significant decrease of low-density lipoprotein cholesterol. The mean serum triglyceride concentration did not change significantly. The fluctuations in the concentration of serum lipids and lipoproteins in 10 women not using oral contraceptives were smaller than in the women using oral contraceptives and no significant changes in the concentrations were found during one cycle.Thus, high-density lipoprotein cholesterol concentration decreases during each contraceptive cycle. Since these concentrations are related to the risk of coronary heart disease,5 precise knowledge of the effect of oral contraceptives is of the utmost importance.The effect of oral contraceptives on high-density lipoprotein cholesterol is a particularly controversial subject, probably because of the qualitative and quantitative differences between the many formulations of drug combinations in use.6 7 Moreover, in most of these studies blood samples were taken on random days of the contraceptive cycle. Furthermore, the concentrations of serum lipids and lipoproteins were assumed to be more or less constant during one cycle. This has, however, never been proved. We therefore studied possible changes in the concentrations of serum lipids and lipoproteins during one contraceptive cycle in women using oral contraceptives and also during one menstrual cycle in women not using them.

show abstract

“…OC use appears frequently to lower HDL concentrations in the blood (30,48). This effect, thought to be due to the progestin component, and recently reported to depend on both the type and amount of progestin (49), might therefore be expected to reduce bile aci~ excretion into the bowel.…”

Section: Exogenous Sex Hormonesmentioning

confidence: 97%

Reproduction, Endogenous and Exogenous Sex Hormones, and Colon Cancer: A Review and Hypothesis

McMichael

Potter

1980

JNCI: Journal of the National Cancer Institute

103

View full text Add to dashboard Cite

Colon cancer is regarded as predominantly a cancer of affluent nutrition. A high intake of dietary fat and a lack of dietary fiber have particularly been implicated in both international correlation studies and analytic studies (1). Internationally, the endocrine-influenced cancers and colon cancer show similar variations, and breast cancer is particularly closely linked with colon cancer (2).There is little overall sex difference in the risk of colon cancer, yet for cancers of most other sex-shared sites the male risk is cleariy higher. Although this approximation of the colon cancer sex ratio (male: female) to unity in Western countries has been noted previously, little attention has been given to two additional details.First, in Western countries, the age-specific colon cance.r sex ratios vary considerably. Below age 35 years, the nsk tends to be higher in males; between ages 35 and 54 years, the risk is higher in females; and at older ages, the male risk again becomes higher. Second, a recent secular trend has occurred in the sex ratio whereby the higher RR in women 35-54 years old ha~ begun to disappear, and, simultaneously, the preponderance in males at older ages has increased further.These two characteristics of the colon cancer sex ratio are displayed in table I for ten countries representative of the three major regions of the Western World: Europe, North America, and Australasia.Any secular changes in the validity of cause-of-death certification should affect the sexes similarly. Hence real changes appear to have occurred in the RR between males and females across both age and time. This suggests, in turn, a sex difference in patterns of recent exposure to etiologic factors. Inasmuch as dietary changes probably impinge similarly on men and women, other sex-related exposures must be considered. Occupational factors appear unimportant (l). Alcohol consumption is more likely to influence rectal cancer than colon cancer, although there is some evidence for the alcohol-colon cancer association (6). The most fruitful source of explanation may therefore reside in hormonal and reproductive factors.When the data from table I are rearranged (table 2) into three. age bands (premenopause, perimenopause, and postmenopause for women) and averaged across countries, the sex ratio appears unexpectedly high at 35-44 years of age during 1970-74 and 1975-77. Within that particular generation of persons around 40 years old in the mid-1970's, the colon cancer death rates have either increased relatively suddenly in males or decreased in females. Changes in actual rates of colon cancer must therefore be examined.

show abstract

Reduced High-Density Lipoprotein in Women Aged 40-41 Using Oral Contraceptives

Cited by 67 publications

References 12 publications

Lipid and Lipoprotein Levels following Pure Estradiol Implantation in Post-Menopausal Women

Lipid and Lipoprotein Levels following Pure Estradiol Implantation in Post-Menopausal Women

Influence of contraceptive pill and menstrual cycle on serum lipids and high-density lipoprotein cholesterol concentrations.

Reproduction, Endogenous and Exogenous Sex Hormones, and Colon Cancer: A Review and Hypothesis

Contact Info

Product

Resources

About