Lipid and Lipoprotein Levels following Pure Estradiol Implantation in Post-Menopausal Women

Шарф, М; Oettinger, Moshe; Lanir, Amos; Kahana, Luna; Yeshurun, Daniel

doi:10.1159/000299035

Cited by 31 publications

(1 citation statement)

References 11 publications

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“…For the purposes of this study, each subject acted as her own control by being studied twice: pre-implantation (on day 21 of the menstrual cycle) and 6 weeks after implantation (but before progestin administration). This interval has previously been shown to allow full expression of metabolic changes induced by hormone implants (Sharf, Oettinger, Lanir, Kahana and Yeshurun 1985). At each visit, venous blood was obtained under standardized conditions after an overnight fast.…”

Section: Methodsmentioning

confidence: 99%

Lipid and Carbohydrate Metabolism in Premenopausal Women Given Subdermal Estradiol Implants

Crook¹,

Montgomery²,

Godsland³

et al. 1991

Horm Metab Res

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Fifteen premenopausal women were studied before and 6 weeks after receiving subcutaneous implants of 100 mg estradiol. Serum estradiol levels doubled; increases were also seen in fasting serum total cholesterol and in high-density lipoprotein cholesterol (HDL). This increase was confined to the HDL2 subfraction, and was not reflected in the HDL apolipoproteins. Low density lipoprotein (LDL) cholesterol levels were unchanged, as were those of apolipoprotein B, the major protein component of LDL. Carbohydrate metabolism was assessed in a subgroup of 12 women. Estrogen implantation reduced fasting plasma glucose levels but did not alter the plasma glucose response to an oral glucose tolerance test. Plasma insulin levels were unchanged both in the fasted state and during the glucose tolerance test. Our findings indicate that parenteral administration of estradiol can alter lipid and carbohydrate metabolism in premenopausal women.

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Section: Methodsmentioning

confidence: 99%