Reduced Hemodynamic Responses to Physical and Mental Stress Under Low-Dose Rilmenidine in Healthy Subjects

Castro, Renata Rodrigues Teixeira de; Tibiriçá, Eduardo; Oliveira, Marcos Aurélio Brazão de; Moreira, Pedro; Catelli, Marcelo Flores; Rocha, Nazareth N.; Nóbrega, Antônio Cláudio Lucas da

doi:10.1007/s10557-006-7653-8

Cited by 3 publications

(2 citation statements)

References 33 publications

(36 reference statements)

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“…Similarly, rilmenidine, an I1 IBS agonist reduces blood pressure in healthy and hypertensive resting subjects (Fauvel et al, 1999;Esler et al, 2004) and decreases peak exercise heart rate without modifying peak aerobic power (Teixeira de Castro et al, 2006). Teixeira de Castro et al (2006) have also shown that rilmenidine inhibits the stress-induced blood pressure increases exerted by mental stress testing (Teixeira de Castro et al, 2006). Evidence with respect to the effects of rilmenidine on sympathetic nervous system activity during physical and mental stress, however, is equivocal and there are a number of studies which report that rilmendine does not alter responses in blood pressure and heart rate induced by physical (Fauvel et al, 1999;Esler et al, 2004) or mental (Esler et al, 2004) stress.…”

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Modulation of stress by imidazoline binding sites: Implications for psychiatric disorders

Smith

Jessop

Finn

2009

Stress

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In this review, we present evidence for the involvement of imidazoline binding sites (IBS) in modulating responses to stress, through central control of monoaminergic and hypothalamo-pituitary-adrenal (HPA) axis activity. Pharmacological and physiological evidence is presented for differential effects of different IBS subtypes on serotoninergic and catecholaminergic pathways involved in control of basal and stress-stimulated HPA axis activity. IBS ligands can modulate behavioural and neuroendocrine responses in animal models of stress, depression and anxiety, and a body of evidence exists for alterations in central IBS expression in psychiatric patients, which can be normalised partially or fully by treatment with antidepressants. Dysfunction in monoaminergic systems and the HPA axis under basal and stress-induced activation has been extensively reported in psychiatric illnesses. On the basis of the literature, we suggest a potential therapeutic role for selective IBS ligands in the treatment of depression and anxiety disorders.

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confidence: 99%

Section: [Insert Figure 2 Here]mentioning

confidence: 99%

Modulation of stress by imidazoline binding sites: Implications for psychiatric disorders

Smith

Jessop

Finn

2009

Stress

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The synergistic interaction between rilmenidine and paracetamol in the writhing test in mice

Soukupová

Doležal

Kršiak

2009

Naunyn-Schmied Arch Pharmacol

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The aim of the study was to ascertain antinociceptive effects of rilmenidine, a second-generation imidazoline-alpha-2-adrenoreceptor agonist, and to see whether rilmenidine was able to increase the analgesic effects of paracetamol in the writhing test in mice. An acetic acid (0.7%) solution was injected into the peritoneal cavity and the number of writhes was counted. The influence on locomotor performance was tested using the rotarod test. Rilmenidine, paracetamol, and rilmenidine-paracetamol fixed-ratio combinations produced dose-dependent antinociceptive effects. ED(50) values were estimated for the individual drugs and an isobologram was constructed. The derived theoretical additive ED(50) value for the rilmenidine-paracetamol combination was 109.23 +/- 35.05 mg/kg. This value was significantly greater than the observed ED(50) value which was 56.35 +/- 20.86 mg/kg, indicating a synergistic interaction. Rilmenidine did not impair motor coordination, as measured by the rotarod test, at antinociceptive and higher doses.

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Chronic Stress in the Development of Essential Hypertension, Role of Rilmenidine in the Treatment of Stress Induced Hypertension

Simonyi¹

2014

AJIM

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Hypertension is an independent risk factor of cardiovascular diseases. Several factors contribute to its development, including chronic stress, which may induce hypertension by increasing sympathetic activity. The signs of increasing sympathetic activity can be primarily detected in the initial phase of hypertension, which is characterized by the increase in cardiac output. In addition to the hemodynamic consequences (increase in cardiac output, tachycardia, coronary vasoconstriction, proarrhythmia), the increase in sympathetic activity has many harmful effects. Numerous metabolic (insulin resistance, dyslipidemia), structural and trophic effects (endothelial dysfunction, vascular hypertrophy, myocardial hypertrophy), as well as thrombotic and humoral processes (procoagulation, enhancement of thrombocyte aggregation, sodium retention, activation of the renin-angiotensin-aldosterone axis) may develop and consequently damage body functions at many targets. Several different antihypertensive drug classes are available for reducing increased sympathetic activity, including peripheral alpha and beta blockers and compounds with central effects. First generation antihypertensive drugs with central mechanisms of action (e.g. clonidine, guanfacine, alpha-methyldopa) is currently rarely administered and only for a few indications as they have a significant adverse events profile. Among second generation compounds with central effects, rilmenidine stimulates imidazoline-1 receptors and thus beneficially influences mild or moderate hypertension that involves enhanced sympathetic nervous system activity.

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Reduced Hemodynamic Responses to Physical and Mental Stress Under Low-Dose Rilmenidine in Healthy Subjects

Cited by 3 publications

References 33 publications

Modulation of stress by imidazoline binding sites: Implications for psychiatric disorders

Modulation of stress by imidazoline binding sites: Implications for psychiatric disorders

The synergistic interaction between rilmenidine and paracetamol in the writhing test in mice

Chronic Stress in the Development of Essential Hypertension, Role of Rilmenidine in the Treatment of Stress Induced Hypertension

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