Reduced graphene oxide-chitosan-aptamer interface as new platform for ultrasensitive detection of human epidermal growth factor receptor 2

Tabasi, Arezoo; Noorbakhsh, Abdollah; Sharifi, Ensiyeh

doi:10.1016/j.bios.2017.04.020

Cited by 121 publications

(42 citation statements)

References 32 publications

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“…Tabasi et al . reported an ultrasensitive biosensor made with an rGO‐chitosan film cast on a GCE surface to detect the human epidermal growth factor receptor 2 protein (HER2) in human serum samples. The use of rGO with chitosan resulted in a homogeneous dispersion with amino groups at the modified electrode surface.…”

Section: Graphene Used In Immunosensingsupporting

confidence: 93%

Thin Films and Composites Based on Graphene for Electrochemical Detection of Biologically‐relevant Molecules

et al. 2018

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Graphene is one of the most studied materials ever, owing to its exceptional electronic, mechanical and thermal properties, which allow for many different types of application. In this review, we shall concentrate on the use of graphene and derivatives for electrochemical sensors and biosensors, where emphasis is placed on the importance of surface functionalization as this permits synergistic combinations with other nanomaterials and biomolecules. In addition to describing recent advances in graphene‐based electroanalytical applications, we discuss a few examples of their use in detecting small biomolecules and in immunosensing for a few diseases using films and composites. Also discussed are the possible methods for mass production of graphene, which is key to low‐cost biosensors for implantable devices and portable systems in point‐of‐care diagnosis.

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Section: Graphene Used In Immunosensingsupporting

confidence: 93%

Thin Films and Composites Based on Graphene for Electrochemical Detection of Biologically‐relevant Molecules

et al. 2018

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“…It is well known that chitosan can be crosslinked by dialdehydes and a molecule such as glutaraldehyde is traditionally used [81], in spite of its critical aspects as for the impact on human health. In the scientific literature, nanocomposites based on chitosan and graphene related materials (i.e., graphene oxide or reduced graphene oxide) have been reported for different applications, such as the preparation of highly compatible membranes [82], the detection of human epidermal growth [83] and bone tissue engineering [84]. Improved properties are expected for the bionanocomposite Reaction between G-CHO and CS was performed as described in the experimental part and schematically shown in Figure 6.…”

Section: Nanocomposites Based On G-cho and Chitosanmentioning

confidence: 99%

Selective edge functionalization of graphene layers with oxygenated groups by means of Reimer–Tiemann and domino Reimer–Tiemann/Cannizzaro reactions

et al. 2018

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“…Applications of nanocomposites are studied in particular for energy storage devices [26], catalyst supports and fuel cells [27], sensors and actuators [28], chemical filters and membranes [29], structural composites [30], biosensors [31] and artificial bone tissues [32]. G and GRM are also increasingly used in the field of catalysis [33,34].…”

Section: Introductionmentioning

confidence: 99%

Facile and sustainable functionalization of graphene layers with pyrrole compounds

Barbera

Bernardi

Palazzolo

et al. 2017

Pure and Applied Chemistry

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A facile and sustainable functionalization of graphene layers was performed with pyrrole compounds (PyC) prepared through the Paal-Knorr reaction of a primary amine with 2,5-hexanedione. A good number of primary amines were used: hexanamine, dodecanamine, octadecanamine, 2-aminoacetic acid, 2-amino-1,3-propanediol, 3-(triethoxysilyl)propan-1-amine. The reactions were characterized by good yield, up to 96 %, and indeed satisfactory atom efficiency, up to 80 %. The functionalization of graphene layers was obtained by mixing PyC with a high surface area graphite and heating at a temperature range from 130 °C to 150 °C for 3 h. The yield of functionalization reaction was larger than 60 % and also up to about 90 % for the pyrrole compounds from dodecanamine and 2-amino-1,3-propanediol, respectively. The cycloaddition reaction between the graphene layers and the pyrrole compound, oxidized in two position, is proposed as working hypothesis to account for such efficient functionalization. Raman spectroscopy revealed that the structure of the graphitic substrate remained substantially unaltered, after the reaction. Stable dispersions of HSAG adducts with different PyC were prepared in solvents with different solubility parameters and HRTEM analysis showed the presence of aggregates of only few layers of graphene. Qualitative results of dispersion tests were used to calculate the Hansen sphere for the HSAG adduct with the pyrrole compound based on dodecanamine so to provide a first estimate of its Hansen solubility parameters. This work paves the way for the facile and sustainable modification of the solubility parameters of graphene layers and for the predictive assessment of their compatibility with different environments.

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Reduced graphene oxide-chitosan-aptamer interface as new platform for ultrasensitive detection of human epidermal growth factor receptor 2

Cited by 121 publications

References 32 publications

Thin Films and Composites Based on Graphene for Electrochemical Detection of Biologically‐relevant Molecules

Thin Films and Composites Based on Graphene for Electrochemical Detection of Biologically‐relevant Molecules

Selective edge functionalization of graphene layers with oxygenated groups by means of Reimer–Tiemann and domino Reimer–Tiemann/Cannizzaro reactions

Facile and sustainable functionalization of graphene layers with pyrrole compounds

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