Reduced glutathione prevents camphorquinone-induced apoptosis in human oral keratinocytes

Evaluation of cell responses toward adhesives with different photoinitiating systems

“…Beside resin monomers, camphorquinone has been shown to rapidly activate the oxidative stress pathway, even without irradiation [29,33]. We therefore also assessed the extent of oxidative stress in the cytotoxic response of the tHPC cells.…”

Genotoxic effects of camphorquinone and DMT on human oral and intestinal cells

“…Previously, it was documented that ROS-levels were elevated in CQ-treated OKF6/TERT2 cells. An additional light irradiation of CQ amplified this effect [25]. Therefore, the significant 8-oxoguanine formation, which we found in our experiments, may have been the result of the marked ROS generation, which triggers oxidative stress in the cell.…”

“…Furthermore, this concentration generated an amount of ROS, which is comparable to 2.5 mM CQ alone [25]. In an additional experiment, the treatment solutions containing the compounds were removed after 6 h and substituted by fresh growth medium.…”

“…Therefore, it was objective of our study to analyze the effects of irradiated and nonirradiated CQ on human oral keratinocytes (OKF6/TERT2), which are one of the first target cells of released resinous substances, and immortalized epithelial colorectal adenocarcinoma cells (Caco-2). Goal of our experiments was to find out, whether CQ causes DNA strand breaks and oxidative DNA modifications due to elevated ROS levels in keratinocytes [25]. The hypothesis, which we set forth, was that non-irradiated CQ without and with DMT significantly elevate ROS levels and is genotoxic in cultures of immortalized human adenocarcinoma cells (Caco-2).…”

Influence of viscosity and amine content on CC conversion and color stability of experimental composites

“…Consequently, the CQ-amine combination is still the most used photoinitiator system in commercially available resinbased dental materials. Nevertheless, questions on the CQ:amine system still persist and studies have been performed to CLARIFY the CQ ability to leach out from polymerized materials [19], the toxicity potential of CQ [20,21] and the influence of CQ and co-initiator concentrations/ratios on a wide range of materials properties, including few reports on the optical characteristics [7,16,22].…”