Reduced glomerular filtration rate due to loss of nephron mass may be an independent risk factor for atherosclerosis

Glodny, Bernhard; Nasseri, Parinaz; Rehder, Peter; Unterholzner, Verena; Plaikner, Michaela; Koppelstätter, Christian; Petersen, Johannes

doi:10.1093/ndt/gfq678

Cited by 8 publications

(10 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The study may be subject to an uncontrollable bias that can occur in retrospective studies, and the fact that the study design is retrospective limits its impact. The method used to quantify the aortic atherosclerotic burden [21, 22] underestimates the actual atherosclerotic burden because it detects only mature plaques, not so-called soft plaques. Most of the variability of the aortic atherosclerotic burden was explained by the parameters examined; the remaining 36.4 % variability must still be considered large.…”

Section: Discussionmentioning

confidence: 99%

“…The strength of this study is that the method of calcium scoring used [21, 22] objectively quantifies the hard plaques of the aorta. Its objectivity sets it apart from all other methods of quantification.…”

Section: Discussionmentioning

confidence: 99%

“…After all structures with a density of less than 600 HU (Fig. 1) were excluded electronically, the volume of the remaining calcified plaques was automatically measured [22]. This means of measuring calcium plaques is an accepted method for a general assessment of cardiovascular status.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

The association of chronic apical periodontitis and endodontic therapy with atherosclerosis

et al. 2013

View full text Add to dashboard Cite

ObjectivesChronic apical periodontitis (CAP) appears to be a risk factor for coronary heart disease. The aims of the study were to estimate the significance of AP for the atherosclerotic burden and to examine the potential effect of endodontic treatment.Materials and methodsThe whole-body computed tomography (CT) examinations of 531 patients with a mean age of 50 ± 15.7 years were evaluated retrospectively. The atherosclerotic burden of the abdominal aorta was quantified using a calcium scoring method. The parameters of periodontitis were measured using the CT scan.ResultsThe patients had a total of 11,191 teeth. The volume of the aortic atherosclerotic burden for patients with at least one CAP lesion was 0.32 ± 0.92 ml, higher than for patients with no CAP (0.17 ± 0.51 ml; p < 0.05). The atherosclerotic burden increased with age and number of CAP lesions without root canal treatment, but not with number of CAP lesions with endodontic treatments (p < 0.05 each). In logistic regression models, age (Wald 90.8), CAP without endodontic treatment (Wald 39.9), male gender (Wald 9.8), and caries per tooth (Wald 9.0) correlated positively and the number of fillings (Wald 11) correlated negatively with the atherosclerotic burden (p < 0.05 each). Apical radiolucencies in teeth with endodontic treatment were irrelevant with respect to atherosclerosis.ConclusionsCAP correlated positively with the aortic atherosclerotic burden. In regression models, CAP without endodontic treatment was found to be an important factor, not however apical radiolucencies in teeth with endodontic treatment.Clinical relevanceFurther research is needed to clarify the possible clinical significance of these associations.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The association of chronic apical periodontitis and endodontic therapy with atherosclerosis

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The aortic calcification was quantified without knowledge of the jaw or dental status using a volumetric calcium scoring method (13). For this process, a defined segment of the abdominal aorta from the celiac trunk to the bifurcation was used.…”

Section: Methodsmentioning

confidence: 99%

The occurrence of dental caries is associated with atherosclerosis

Glodny¹,

Nasseri²,

Crismani³

et al. 2013

Clinics

View full text Add to dashboard Cite

OBJECTIVE:Previous studies have suggested that marginal periodontitis is a risk factor for developing atherosclerosis. The objective of this study was to determine whether caries may also be associated with atherosclerosis.METHODS:The computed tomography data sets of 292 consecutive patients, 137 women and 155 men with a mean age of 54.1±17.3 years, were analyzed. Caries were quantified based on the number of decayed surfaces of all the teeth, and periodontitis was quantified on the basis of the horizontal bone loss in the jaw. The presence of chronic apical periodontitis (CAP) was assessed, and the aortic atherosclerotic burden was quantified using a calcium scoring method.RESULTS:The patients with <1 caries surfaces/tooth had a lower atherosclerotic burden (0.13±0.61 mL) than patients with ≥1 caries surfaces/tooth. The atherosclerotic burden was greater in patients with a higher number of lesions with pulpal involvement and more teeth with chronic apical periodontitis. In the logistical regression models, age (Wald 49.3), number of caries per tooth (Wald 26.4), periodontitis (Wald 8.6), and male gender (Wald 11) were found to be independent risk factors for atherosclerosis. In the linear regression analyses, age and the number of decayed surfaces per tooth were identified as influencing factors associated with a higher atherosclerotic burden, and the number of restorations per tooth was associated with a lower atherosclerotic burden.CONCLUSION:Dental caries, pulpal caries, and chronic apical periodontitis are associated positively, while restorations are associated inversely, with aortic atherosclerotic burden. Prospective studies are required to confirm these observations and answer the question of possible causality.

show abstract

“…26 The hypothesis that kidney size and resulting kidney function lead to a slight protection against atherosclerosis could potentially explain the somewhat higher plasma renin in patients with MRAs, 12 namely, that it is due to the greater kidney length. The somewhat higher blood pressure in patients with MRAs in the study cited could have been a selection bias effect, as most of these patients presented owing to arterial hypertension.…”

Section: Discussionmentioning

confidence: 99%

Influence of Renal Artery Variants, Number, Location, and Degree of Renal Artery Stenoses on the Atherosclerotic Burden of the Aorta

Petersen

Plaikner

Nasseri

et al. 2012

Journal of Investigative Medicine

View full text Add to dashboard Cite

show abstract

Reduced glomerular filtration rate due to loss of nephron mass may be an independent risk factor for atherosclerosis

Abstract: The factors 'low GFR' and RNM are risk factors for greater atherosclerotic plaque burden. Patients with RNM should undergo regular control examinations to monitor arterial blood pressure and treat hypertension if it occurs.

Cited by 8 publications

References 30 publications

The association of chronic apical periodontitis and endodontic therapy with atherosclerosis

The association of chronic apical periodontitis and endodontic therapy with atherosclerosis

The occurrence of dental caries is associated with atherosclerosis

Influence of Renal Artery Variants, Number, Location, and Degree of Renal Artery Stenoses on the Atherosclerotic Burden of the Aorta

Contact Info

Product

Resources

About