Reduced frequency of CD4+CD25HIGHFOXP3+ cells and diminished FOXP3 expression in patients with Common Variable Immunodeficiency: A link to autoimmunity?

Genre, Julieta; Errante, Paolo Ruggero; Kokron, Cristina Maria; Toledo-Barros, Myrthes; Câmara, Niels Olsen Saraiva; Rizzo, Luiz Vicente

doi:10.1016/j.clim.2009.03.519

Cited by 84 publications

(62 citation statements)

References 25 publications

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“…No differences were seen in the TGF-β concentration between patients and the control group [36]. Genre et al [66] and Holm et al [67] reported a decreased level of IL-10 in CVID. Regarding abnormality of Treg cells in CVID patients, it could be concluded that cellular dysregulation, including an elevated activated CD4 + T-cell count, may be a consequence of lower numbers and reduced suppressive capacity of Treg cells, especially in patients with autoimmune manifestations.…”

Section: Regulatory T-cell Defectsmentioning

confidence: 89%

“…There is a significant correlation between low numbers of Treg cells and autoimmune manifestations [61,63,65,66], granulomatous lesions [65], and splenomegaly [61]. Genre et al [66] reported that CVID patients who were likely to develop autoimmunity had a significantly reduced frequency of Treg cells accompanied by decreased intensity of Foxp3 expression.…”

Section: Regulatory T-cell Defectsmentioning

confidence: 99%

Section: Regulatory T-cell Defectsmentioning

confidence: 99%

“…Genre et al [66] reported that CVID patients who were likely to develop autoimmunity had a significantly reduced frequency of Treg cells accompanied by decreased intensity of Foxp3 expression. Moreover, levels of expression of Foxp3 in CVID patients without autoimmunity did not differ from those in healthy individuals [66]. Arumugakani et al [61] showed that a low frequency of Treg cells was correlated with expansion of CD21 low B cells in CVID patients with autoimmunity, while a significantly reduced frequency and number of Treg cells was observed in patients with splenomegaly.…”

Section: Regulatory T-cell Defectsmentioning

confidence: 99%

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T-Cell Abnormalities in Common Variable Immunodeficiency

Azizi

Rezaei

Kiaee

et al. 2016

J Investig Allergol Clin Immunol

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Common variable immunodeficiency (CVID) is the most common clinical primary immunodeficiency. It is characterized by a defect in B-cell differentiation to plasma and memory B cells. Moreover, numerous T-cell abnormalities have been reported and include decreased T-cell count and proliferative response, increased T-cell activation and apoptosis, and abnormalities in cytokine production. The aims of this review are to describe phenotypic and functional defects in T cells in CVID patients and to review the literature with respect to the effects of immunoglobulin replacement on the T-cell component in CVID patients. Key words: Common variable immunodeficiency. T cell. Helper T cells. Regulatory T cells. ResumenLa inmunodeficiencia común variable (CVID) es la inmunodeficiencia primaria más frecuente. Se caracteriza por un defecto en la diferenciación de linfocitos B hacia células plasmáticas y linfocitos B memoria. Se han descrito numerosas alteraciones en los linfocitos T de estos pacientes, tales como disminución en el número de linfocitos T y en sus respuestas proliferativas, aumento en la activación de células T y en la apoptosis, así como alteraciones en la producción de citokinas. El objetivo de esta revisión es describir las alteraciones funcionales y fenotípicas de los linfocitos T en los pacientes con CVID y revisar la bibliografía en relación a los efectos que la administración de inmunoglobulinas produce en los linfocitos T de los pacientes con CVID. Palabras clave: Inmunodeficiencia común variable. Células T. Células T helper. Células T reguladoras.

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Section: Regulatory T-cell Defectsmentioning

confidence: 89%

Section: Regulatory T-cell Defectsmentioning

confidence: 99%

Section: Regulatory T-cell Defectsmentioning

confidence: 99%

Section: Regulatory T-cell Defectsmentioning

confidence: 99%

See 2 more Smart Citations

T-Cell Abnormalities in Common Variable Immunodeficiency

Azizi

Rezaei

Kiaee

et al. 2016

J Investig Allergol Clin Immunol

View full text Add to dashboard Cite

show abstract

“…Natural Treg (CD4+/CD25+/FoxP3+) from thymus and iTreg (inducible Treg) are involved in monitoring the immune response, maintaining the immune balance, prevention of excessive and potentially harmful immune activation within mucous of gastrointestinal tract [47,[61][62]. The study of Treg lymphocytes (CD4/CD25/FoxP3) within the lamina propria patients with Leśniowski-Crohn's disease and UC showed increased number of these cells; whereas the number in peripheral blood was decreased as compare to healthy people.…”

Section: 12the Histology Of Jejunum In Celiac Disease and Leśniowmentioning

confidence: 99%