Celiac And Inflammatory Bowel Diseases In Children With Primary Humoral Immunodeficiency

Pituch-Noworolska,; Zwonarz, Katarzyna

doi:10.5772/50219

Cited by 6 publications

(5 citation statements)

References 60 publications

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“…For many years, the serologic diagnosis of coeliac disease was based on the detection of IgA anti‐endomysial antibodies (EMA), IgA and IgG antigliadin antibodies (AGA), and antitissue transglutaminase antibodies (AtTGA) as well as IgA antireticulin antibodies . It has been demonstrated that the levels of these autoantibodies in the serum of PID patients are often lower than in patients without PID . For example, in CVID the serological diagnosis of coeliac disease is more difficultly and doubtfully made due to low production of both IgG and IgA antibodies, .…”

Section: Management Of Autoimmunity In Pid Patientsmentioning

confidence: 99%

Approach to the Management of Autoimmunity in Primary Immunodeficiency

Azizi

Ziaee

Tavakol³

et al. 2017

Scand J Immunol

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Primary immunodeficiency diseases (PIDs) consist of a genetically heterogeneous group of immune disorders that affect distinct elements of the immune system. PID patients are more prone to infections and non-infectious complications, particularly autoimmunity. The concomitance of immunodeficiency and autoimmunity appears to be paradoxical and leads to difficulty in the management of autoimmune complications in PID patients. Therefore, management of autoimmunity in patients with PID requires special considerations because dysregulations and dysfunctions of the immune system along with persistent inflammation impair the process of diagnosis and treatment.

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Section: Management Of Autoimmunity In Pid Patientsmentioning

confidence: 99%

Approach to the Management of Autoimmunity in Primary Immunodeficiency

Azizi

Ziaee

Tavakol³

et al. 2017

Scand J Immunol

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“…gliadin) is enough to induce and to support the synthesis of antibodies/autoantibodies, overcoming the impaired function of immune system. The level of autoantibodies in serum is often lower than in patients without immune deficiency [54,[56][57][58]. In our observations, these antibodies present in low level were clinically significant, so, they should be considered in CVID patients as marker of celiac disease.…”

Section: Production Of Autoantibodies In Immunodeficiencymentioning

confidence: 51%

“…In biopsy of jejunum mucous in celiac or Leśniowski-Crohn's disease in CVID patients, the infiltrates contain T lymphocytes, almost exclusively, with low number of B and plasma cells. To differentiate atypical histological pattern of intestine infiltrates in CVID from typical histology of affected intestine in otherwise healthy patients, the celiac disease and Leśniowski-Crohn's disease are termed "celiac-like, " and "Crohn-like" for CVID patients [8,[55][56][57].…”

Section: Production Of Autoantibodies In Immunodeficiencymentioning

confidence: 99%

Autoimmunity in Children with Primary Immunodeficiency – Diagnosis, Management and Therapy

Pituch‐Noworolska¹

2015

Autoimmunity - Pathogenesis, Clinical Aspects and Therapy of Specific Autoimmune Diseases

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“…Untreated celiac disease in young adults leads to unexplained subfertility, recurrent miscarriages, increasing the risk of lymphoma and gastric/large bowel carcinoma. The therapy is based on restricted gluten-free diet (GFD) [26][27][28][29][47][48][49][50]. In humoral immunodeficiency, in about 5% of patients, the celiac disease is refractory to GFD.…”

Section: Celiac Diseasementioning

confidence: 99%

Autoimmunity of Gastrointestinal Tract

Pituch‐Noworolska¹,

Mach-Tomalska²

2017

Immunopathogenesis and Immune-Based Therapy for Selected Autoimmune Disorders

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Gastrointestinal tract diseases are recognised as autoimmune based on typical histopathology, presence of autoantibodies in serum and clinical response to immunosuppressive therapy. Like in other autoimmune diseases, the inducing factor is unknown; however, accumulating data suggests an increasing role of microbiota homeostasis and relation between the immune system (mucous-associated lymphoid tissue) and microbiota in intestinal lumen. The inflammation process is now described as autoinflammation with inflammasome formation or autoimmune chronic inflammation with overproduction of pro-inflammatory cytokines. Diagnostic procedures include autoantibodies assay, histology of biopsy from intestinal mucous, genetic background (especially in celiac disease) and clinical symptoms. Therapy is adjusted to pathomechanism including regulation of microbiota homeostasis with pre-biotics and probiotics, inhibition of inflammatory process with steroids, classical immunosuppression and anti-cytokine monoclonal antibodies and haematopoietic stem cells transplantation in severe cases with therapy resistance, progression and life-threatening course. The aim of this chapter is to review mechanisms of autoinflammation and autoimmunity, diagnosis and therapy of gastrointestinal tract.

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Celiac And Inflammatory Bowel Diseases In Children With Primary Humoral Immunodeficiency

Cited by 6 publications

References 60 publications

Approach to the Management of Autoimmunity in Primary Immunodeficiency

Approach to the Management of Autoimmunity in Primary Immunodeficiency

Autoimmunity in Children with Primary Immunodeficiency – Diagnosis, Management and Therapy

Autoimmunity of Gastrointestinal Tract

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