Reduced Degradation of the Chemokine MCP-3 by Matrix Metalloproteinase-2 Exacerbates Myocardial Inflammation in Experimental Viral Cardiomyopathy

Westermann, Dirk; Savvatis, Kostas; Lindner, Diana; Zietsch, Christin; Becher, Peter Moritz; Hammer, Elke; Heimesaat, Markus M.; Bereswill, Stefan; Völker, Uwe; Escher, Felicitas; Riad, Alexander; Plendl, Johanna; Klingel, Karin; Poller, Wolfgang; Schultheiss, Heinz‐Peter; Tschöpe, Carsten

doi:10.1161/circulationaha.111.035964

Cited by 82 publications

(72 citation statements)

References 38 publications

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“…25 In addition to their canonical function in ECM remodeling, researches in the last decade have highlighted new MMP-2 functions, including proteolysis of novel substrates beyond ECM proteins such as troponin I, 26 localization to subcellular organelles such as mitochondria, 27 and proteolysis of susceptible intracellular proteins in those subcellular compartments such as monocyte chemoattractant protein-3. 28 Therefore, inhibition of MMP-2 and MMP-9 is considered as an important target for therapeutic intervention of cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Polyphenols and Polypeptides in Chinese Rice Wine Inhibit Homocysteine-induced Proliferation and Migration of Vascular Smooth Muscle Cells

Meng

Liu

Zhou

et al. 2016

Journal of Cardiovascular Pharmacology

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The beneficial effect of Chinese rice wine on atherosclerosis has been proved, but the exact components that have the cardiovascular protective effect are still unknown. This study aimed to explore the exact ingredients in Chinese rice wine that could inhibit homocysteine (Hcy)-induced vascular smooth muscle cell (VSMC) proliferation and migration. VSMCs were divided into 7 groups: control, Hcy (1 mmol/L), Hcy + oligosaccharide, Hcy + polypeptides, Hcy + polyphenols, Hcy + alcohol, and Hcy + Chinese rice wine. methyl thiazolyl tetrazolium (MTT) assay, Transwell chambers, and wound-healing assay were used to test the proliferation and migratory ability of the VSMCs. Western blot and gelatin zymography were used to investigate the expressions and activities of metal matrix proteinase 2/9 (MMP-2/9) and tissue inhibitor of metalloproteinase 2 (TIMP-2) in VSMCs. Polypeptides and polyphenols in the Chinese rice wine reduced the proliferation and migration ability of the VSMCs. Furthermore, they also decreased the expression and activity of MMP-2/9 but had no obvious impact on the expression of TIMP-2 in each group. This study further confirms that polypeptides and polyphenols in the Chinese rice wine could inhibit Hcy-induced proliferation and migration of VSMCs and maintain the balance between matrix metalloproteinases (MMPs) and TIMPs.

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Section: Discussionmentioning

confidence: 99%

Polyphenols and Polypeptides in Chinese Rice Wine Inhibit Homocysteine-induced Proliferation and Migration of Vascular Smooth Muscle Cells

Meng

Liu

Zhou

et al. 2016

Journal of Cardiovascular Pharmacology

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“…Concurrently, miR-23a expression upregulation decreased the expression of the putative target CCL7, an important proinflammatory factor whose increasing levels can exacerbate myocardial inflammation [32,33]. As such, miR-23a is probably another important negative regulator of VMC.…”

Section: Discussionmentioning

confidence: 99%

MicroRNAs Regulate the Pathogenesis of CVB3-Induced Viral Myocarditis

Zhang

Xiao

et al. 2012

Intervirology

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Aims: To evaluate the role of microRNAs (miRNAs) in the pathogenesis of Coxsackievirus B3 (CVB3)-induced viral myocarditis. Methods: We detected miRNA expression profiling by microarray utilizing a mouse model on day 4 after CVB3 infection. Then we validated differentially expressed miRNAs using real-time polymerase chain reaction (PCR). We predicted target genes using miRNA target prediction databases and assessed them using mRNA microarray and qualitative reverse transcription PCR measurements. By analyzing the target function of differentially expressed miRNAs, we initially explored the regulating role of miRNAs in viral myocarditis. Results: We found five differentially expressed miRNAs that are involved in regulating several important innate immune and antiviral pathways such as the Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, NOD-like receptor signaling pathway, cytokine- cytokine receptor interaction, MAPK signaling pathway, JAK-STAT signaling pathway, and natural killer cell-mediated cytotoxicity. Conclusion: miRNAs regulate the pathogenesis of viral myocarditis. This study may provide a new perspective and a deeper understanding of the pathogenesis of viral myocarditis that may help with the development of novel therapies against CVB3 infection.

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“…Li, et al, 2002;Westermann, et al, 2011) and heart failure (dilated cardiomyopathy) (Y. Y. Li, et al, 2001).…”

Section: Preventing Fibrosis: Targeting the Matrix Metalloproteinasesmentioning

confidence: 99%

Emerging pharmacologic targets and treatments for myocarditis

Jensen

Marchant

2016

Pharmacology & Therapeutics

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Reduced Degradation of the Chemokine MCP-3 by Matrix Metalloproteinase-2 Exacerbates Myocardial Inflammation in Experimental Viral Cardiomyopathy

Cited by 82 publications

References 38 publications

Polyphenols and Polypeptides in Chinese Rice Wine Inhibit Homocysteine-induced Proliferation and Migration of Vascular Smooth Muscle Cells

Polyphenols and Polypeptides in Chinese Rice Wine Inhibit Homocysteine-induced Proliferation and Migration of Vascular Smooth Muscle Cells

MicroRNAs Regulate the Pathogenesis of CVB3-Induced Viral Myocarditis

Emerging pharmacologic targets and treatments for myocarditis

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