Reduced brain corticotropin‐releasing factor receptor activation is required for adequate maternal care and maternal aggression in lactating rats

Klampfl, Stefanie M.; Neumann, Inga D.; Bosch, Oliver J.

doi:10.1111/ejn.12274

Cited by 42 publications

(57 citation statements)

References 56 publications

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“…Recently, we have demonstrated that hypo-activation of CRF-R centrally (Klampfl et al, 2013) as well as in the medial-posterior BNST (mpBNST) or the anterior-dorsal BNST (adBNST) is essential for the adequate expression of maternal behavior and for the hypo-anxious state in lactating rats. Activation of CRF-R2 in the mpBNST and of CRF-R1 in the adBNST results in a strong reduction of maternal behavior while both receptor subtypes concomitantly mediate maternal anxiety in the mpBNST, but not the adBNST.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Brain CRF-binding protein modulates aspects of maternal behavior under stressful conditions and supports a hypo-anxious state in lactating rats

Klampfl

Schramm

Stinnett

et al. 2016

Hormones and Behavior

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Section: Accepted Manuscriptmentioning

confidence: 99%

“…For experiment 1 -3, pregnant females were also single-housed after surgery to guarantee recovery and undisturbed delivery (Klampfl et al, 2013). On the day of birth, litters were culled to eight pups of mixed sexes.…”

Section: Animalsmentioning

confidence: 99%

Brain CRF-binding protein modulates aspects of maternal behavior under stressful conditions and supports a hypo-anxious state in lactating rats

Klampfl

Schramm

Stinnett

et al. 2016

Hormones and Behavior

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“…This is associated with elevated levels of Crh mRNA in the pPVN under basal conditions. It is not known whether prenatal social stress affects CRH expression in other regions of the brain; however, as the activation of the central CRH system is known to impair maternal behaviour (Pedersen et al 1991, Gammie et al 2004, Klampfl et al 2013, this may contribute to reduced mother-pup interactions and reduced nursing.…”

Section: Maternal Behaviour In Rodentsmentioning

confidence: 99%

Effects of maternal exposure to social stress during pregnancy: consequences for mother and offspring

2013

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A suboptimal in utero environment, for example, as a result of maternal stress, can have detrimental effects on the pregnancy and long-term adverse 'programming' effects on the offspring. This article focuses on the effects of prenatal social stress on the mother, her pregnancy and the offspring, since these issues have ethological relevance in both animals and humans. The consequences of social stress exposure depend on when during pregnancy the stress occurs, and many of the effects on the offspring are sex specific. Social stress during early pregnancy tends to result in pregnancy loss, whereas stress exposure later in pregnancy, when the mother has already invested considerable resources in the foetuses, results in programmed offspring of low birth weight: a risk factor for various adulthood diseases. Neuroendocrine and behavioural responses to stress in the offspring are particularly sensitive to foetal programming by prenatal stress, indicated by enhanced hypothalamo-pituitary-adrenal (HPA) axis responses and increased anxiety behaviour, which result from permanent changes in the offspring's brain. The dysregulation of HPA axis function may also interfere with other systems, for example, the hypothalamic-pituitary-gonadal axis, as there is evidence for alterations in steroidogenesis, reproductive potential and impaired reproductive/social behaviours in prenatally stressed offspring. Prenatal social stress also programmes future maternal behaviour, highlighting the potential for negative phenotypes to be transmitted to future generations. The possible mechanisms through which maternal stress during pregnancy is transmitted to the foetuses and the foetal brain is programmed by prenatal stress and the potential to overwrite programming of the offspring are discussed.Reproduction (2013) 146 R175-R189

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“…These results are consistent with previous studies showing that high-licking dams are less neophobic than low-licking dams (Francis, Champagne, and Meaney, 2000) and that, more generally, postpartum rats display less anxiety-related behavior than nulliparous females (reviewed in Lonstein, 2007). This lower "trait-level of emotional reactivity observed in the more maternally responsive females may be what allows them to be more accepting of and attentive to pups, and may be regulated by differences in their central GABA, oxytocin, and corticotropin releasing hormone receptor signaling (Walker et al, 2001;Klampfl et al, 2013;Hansen, Ferreira, and Selart, 1985;Lonstein, Maguire, Meinlschmidt, and Neumann, 2014).…”

mentioning

confidence: 99%

Associations among within-litter differences in early mothering received and later emotional behaviors, mothering, and cortical tryptophan hydroxylase-2 expression in female laboratory rats

Ragan

Harding

Lonstein

2016

Hormones and Behavior

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This article is part of a Special Issue "Parental Care". The effects of differential maternal care received on offspring phenotype in rodents has been extensively studied between litters, but the consequences of differential mothering within litters on offspring neurobehavioral development have been rarely examined. We here investigated how variability in maternal care received among female rat siblings (measured four times daily on postnatal days 4, 6, 8, and 10) relates to the siblings' later emotional and maternal behaviors. As previously reported, we found that some female pups received up to three times more maternal licking bouts compared to their sisters; this difference was positively correlated with the pups' body weights. The number of maternal licking bouts that females received was negatively correlated with their later neophobic behaviors in an open field during periadolescence, but positively correlated with their anxiety-related behavior in an elevated plus maze during adulthood. Licking received was also positively correlated with females' later likelihood to retrieve pups in a maternal sensitization paradigm. In addition, females' neophobia during adolescence and anxiety-related behavior during adulthood predicted some aspects of both postpartum and sensitized maternal responsiveness. Medial prefrontal cortex expression of tryptophan hydroxylase-2 (TPH2; enzyme necessary for serotonin synthesis) was negatively associated with early maternal licking received. Interestingly, cortical TPH2 was positively associated with the maternal responsiveness of sensitized virgins but negatively associated with it in postpartum females. These results indicate that within-litter differences in maternal care received is an often neglected, but important, contributor to individual differences in offspring socioemotional behaviors as well as to the cortical serotonin neurochemistry that may influence these behaviors.

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Reduced brain corticotropin‐releasing factor receptor activation is required for adequate maternal care and maternal aggression in lactating rats

Cited by 42 publications

References 56 publications

Brain CRF-binding protein modulates aspects of maternal behavior under stressful conditions and supports a hypo-anxious state in lactating rats

Brain CRF-binding protein modulates aspects of maternal behavior under stressful conditions and supports a hypo-anxious state in lactating rats

Effects of maternal exposure to social stress during pregnancy: consequences for mother and offspring

Associations among within-litter differences in early mothering received and later emotional behaviors, mothering, and cortical tryptophan hydroxylase-2 expression in female laboratory rats

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