Reduced bone formation after exposure to organophosphates

Compston, JE; Vedi, S.; Stephen, A. B.; Bord, S.; Lyons, AR; Hodges, SJ; Scammell, B.E.

doi:10.1016/s0140-6736(99)04466-9

Cited by 34 publications

(28 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results by Lari et al (2012) indicate that DZN toxicity is associated with decrease in trabecular and cortical bone density and might be one of the causes for worldwide increasing prevalence of osteoporosis. Significant reduction in bone mass and density in individuals following chronic low-level intoxication with OP pesticides was also reported in the study by Compston et al (1999). Higher amounts of DZN caused additional defects in quail and chicken including folding of the spinal chord, shortening of the neck (Wyttenbach & Hwang 1984), fusing and twisting of vertebrae, abnormal development of ribs and breastbone (Meneely & Wyttenbach 1989), curled claws, reduced growth of leg and wing bones (Cho & Lee 1990), and reduced bone calcification (Cho & Lee 1991).…”

Section: Introductionsupporting

confidence: 71%

“…Moreover, DZN is a potential inhibitor of AChE activity. This enzyme is important in the cell-matrix adhesive interactions and in the coupling of bone resorption to bone formation (Compston et al 1999). Therefore, higher bone resorption manifested by the presence of resorption lacunae in our study could also be attributed to DZN-induced inhibition of AChE.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Acute and subchronic co-administrations to cadmium, diazinon and selenium induce apparent osteoporotic symptoms in adult male rats

et al. 2014

View full text Add to dashboard Cite

Cadmium (Cd) and diazinon (DZN) are known to be environmental risk factors for various bone diseases including osteoporosis. Selenium (Se), an essential constituent of many antioxidant enzymes, has in higher concentrations negative effects on the bone. The present study was aimed to investigate possible changes in femoral bone of adult male rats after their acute and subchronic exposures to Cd, DZN and Se. A total of 30 male Wistar rats were randomized into three experimental groups. The rats in the group A (4-months-old) were injected intraperitoneally with a mixture of 2 mg CdCl2 kg −1 , 20 mg DZN kg −1 and 2 mg Na2SeO3 kg −1 body weight and killed 36 h after xenobiotics had been injected. In the group B, young males (1-month-old) were administered with a combination of 30 mg CdCl2 L −1 , 40 mg DZN L −1 and 5 mg Na2SeO3 L −1 in their drinking water, for 90 days. Ten 4-months-old males without toxicant supplementation served as a control group (C). After treatment period, detailed histological analysis of femoral bone was performed in each group. Our results revealed apparent osteoporotic symptoms (resorption lacunae, osteoporotic fractures) in rats from groups A and B. Moreover, histomorphometrical evaluation showed reduced bone vascularization (constricted primary osteons' vascular canals and Haversian canals) and weakness mechanical properties of bones (smaller size of the secondary osteons) in these rats in comparison with those of the control group. Our study demonstrates for the first time that acute and subchronic co-administrations to Cd, DZN and Se induce evident manifestation characteristics of osteoporosis in male rats.

show abstract

Section: Introductionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Acute and subchronic co-administrations to cadmium, diazinon and selenium induce apparent osteoporotic symptoms in adult male rats

et al. 2014

View full text Add to dashboard Cite

show abstract

“…To understand the relationship between health problems and occupational exposure, the collection of data and biological observation methods must be ensured. 1,5,9,10 …”

Section: Discussionmentioning

confidence: 99%

“…Negative effects of the occupational and environmental exposures on human health with respect to the intensive use of pesticides may involve review by forensic medical practitioners. 5,6 The legal codification and educational requirements of pesticide users are discussed.…”

Section: Introductionmentioning

confidence: 99%

Pesticide use among greenhouse workers in Turkey

Ergönen

Salaçin

Özdemir

2005

Journal of Clinical Forensic Medicine

View full text Add to dashboard Cite

“…were enumerated as described in [6,8]. Triplicate 1-ml aliquots of the farm Table 1 Animal slurry-SP-sheep dip microcosms SP-sheep dip (ml) in dH 2 slurry dilutions were pipetted into bijou bottles and topped up with Preston selective enrichment broth leaving su¤cient headspace to allow the development of microaerophilic conditions. After incubation for 4 h at 37³C and 44 h at 42³C, samples were loop-streaked onto modi¢ed Campylobacter charcoal deoxycholate agar and incubated for 48 h at 42³C under microaerophilic conditions.…”

Section: Campylobactermentioning

confidence: 99%

Impact of synthetic pyrethroid-sheep dip on the indigenous microflora of animal slurries

Semple

2000

FEMS Microbiology Letters

View full text Add to dashboard Cite

The chemical constituents of sheep dip in the UK are currently changing from organophosphate-based to synthetic pyrethroid-based insecticides. As a result, changes are also being made to the methods of disposal of these chemicals in the environment, such that pyrethroid sheep dips must now be diluted in animal slurry or water. To date, there is a lack of quantitative information on the impact of the insecticide on the indigenous microflora of animal slurries. This paper investigated the impact of Bayticol (synthetic pyrethroid sheep dip) over a range of concentrations on selected populations of bacteria within animal slurry. It was found that, with increasing pesticide concentration, there was up to a four orders of magnitude increase in the numbers of faecal coliforms and pathogens, such as putative Salmonella spp. These findings have implications for the disposal of sheep dip-amended animal slurries to land from several aspects: (i) the longevity of putative pathogens in the field may require re-evaluation of the time required before the return of grazing livestock to a slurry-amended field; (ii) the potential for the transfer of pathogenic bacteria and faecal coliforms into human and animal foodchains, and (iii) the increased potential for faecal coliforms being washed into streams, rivers and coastal bathing waters. ß

show abstract

Reduced bone formation after exposure to organophosphates

Cited by 34 publications

References 3 publications

Acute and subchronic co-administrations to cadmium, diazinon and selenium induce apparent osteoporotic symptoms in adult male rats

Acute and subchronic co-administrations to cadmium, diazinon and selenium induce apparent osteoporotic symptoms in adult male rats

Pesticide use among greenhouse workers in Turkey

Impact of synthetic pyrethroid-sheep dip on the indigenous microflora of animal slurries

Contact Info

Product

Resources

About