2021
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Abstract: Renal cell carcinoma (RCC) is one of the most lethal urological cancers, highly resistant to chemo and radiotherapy. Obesity and smoking are the best-known risk factors of RCC, both related to oxidative stress presence, suggesting a significant role in RCC development and maintenance. Surgical resection is the treatment of choice for localized RCC; however, this neoplasia is hardly diagnosable at its initial stages, occurring commonly in late phases and even when metastasis is already present. Systemic therapi… Show more

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Cited by 4 publications
(1 citation statement)
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References 172 publications
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“…The parallel decline suggests that increased stress from excess iA␤ is just one of many possible age-related stressors possibly associated with inflammation. Oxidative redox stress is well known to alter signaling through sensitivity to dimerization of growth factor receptors, NfkB and Akt signaling (e.g., [99,100]) and possibly A␤PP processing [101]. We did not see evidence of circadian oscillation, possibly related to tighter control of redox state in the brain compared to plasma.…”
Section: Glutathione and Redox Statecontrasting
confidence: 60%