Abstract:Purpose
In recent years, metabolic alteration has been identified as a driver in the development of renal cell carcinoma (RCC), which plays a critical role in cancer cells to adapt to hypoxic environment and cell proliferation. Melatonin (MLT), a neurohormone secreted during the dark hours by the vertebrate pineal gland, induces metabolic reprogramming in cancer cells by suppression of aerobic glycolysis. Whether it can be used as a potential therapeutic tool in RCC is worth exploring.
Methods
In this study,… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.