Redox sensitive lipid-camptothecin conjugate encapsulated solid lipid nanoparticles for oral delivery

Du, Yawei; Ling, Longbing; Ismail, Muhammad; He, Wei; Xia, Qing; Zhou, Wenxia; Chen, Yao; Li, Xinsong

doi:10.1016/j.ijpharm.2018.08.010

Cited by 52 publications

(32 citation statements)

References 36 publications

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“…Camptothecins constitute a class of anticancer alkaloid traditionally from Chinese medicine that possesses potential anticancer activity against colon, breast, colorectal, stomach, liver, leukemia, and ovarian cancers. Their mechanism of action involves inhibition of tumor-specific topoisomerase I, a critical enzyme responsible for cutting and re-ligating single DNA strands, which results in DNA damage 40–43. The pharmacokinetic profile and anticancer activity of nanocrystals and PEG-PBLG loaded into hydroxycamptothecin (HCPT) were evaluated in rats and rabbits 40,41.…”

Section: Resultsmentioning

confidence: 99%

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<p>Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review</p>

Omar

Na‐Bangchang

2019

IJN

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The poor pharmacokinetic characteristics of most anticancer drugs have limited their clinical effectiveness. The application of nanoparticles as a novel drug delivery system has provided opportunities to tackle the current challenges facing conventional drug delivery systems such as poor pharmacokinetics, lack of specificity to tumor cells, multidrug resistance, and toxicity. This systematic review aims to examine the application of pharmacokinetic studies of nanoparticles loaded in conventional drugs and herb-derived compounds for cancer therapy. The pharmacokinetic parameters of several herbal medicines and chemotherapeutic drugs loaded into nanoparticles were reported. This included area under the curve (AUC) of plasma concentration–time profile, maximum plasma concentration (Cmax), time to maximum plasma concentration (Tmax), volume of distribution (Vd or Vss), elimination half-life (t½), and clearance (CL). The systematic review was conducted using information available in the PubMed and Science Direct databases up to February 2019. The search terms employed were: pharmacokinetics, pharmacokinetic study, nanoparticles, anticancer, traditional medicine, herbal medicine, herb-derived compounds, natural products, and chemotherapy. Overall, nanoparticle carriers not only significantly improved pharmacokinetics but also further enhanced permeability, solubility, stability, specificity, and selectivity of the carried anticancer drugs/herb-derived compounds to target tumor cells. Additionally, they also limited hepatic first-pass metabolism and P-glycoprotein (P-gp) efflux of the carried anticancer drugs/herb-derived compounds. Based on this systematic review, polymeric nanoparticles were the most commonly used nanocarrier to improve the pharmacokinetic parameters. The use of nanoparticles as a novel drug delivery system has the potential to improve both pharmacokinetics and cytotoxicity activity of the loaded drugs/herb-derived compounds for cancer therapy.

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Section: Resultsmentioning

confidence: 99%

“…The increased bioavailability was associated with enhanced cytotoxic activity against SKOV3 cancer cells. Similarly, the bioavailability of the solid lipid nanoparticles (SLN) delivering camptothecin (CPT) was shown to be improved by 2.38-fold 43…”

Section: Resultsmentioning

confidence: 99%

<p>Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review</p>

Omar

Na‐Bangchang

2019

IJN

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“…[ 35 ] Disulfide bond linked CPT and palmitic acid prodrug conjugates can formed NPs and achieved high oral absorption and reduced intestinal side effect for cancer treatment. [ 36 ] To improve the clinical potential of CPT based nanoformulaiton in tumor therapy, phosphorylcholine was introduced into CPT prodrug conjugates. [ 37 , 38 , 39 ]…”

Section: Small Molecule Prodnmsmentioning

confidence: 99%

Nanoparticulation of Prodrug into Medicines for Cancer Therapy

et al. 2021

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This article provides a broad spectrum about the nanoprodrug fabrication advances co-driven by prodrug and nanotechnology development to potentiate cancer treatment. The nanoprodrug inherits the features of both prodrug concept and nanomedicine know-how, attempts to solve underexploited challenge in cancer treatment cooperatively. Prodrugs can release bioactive drugs on-demand at specific sites to reduce systemic toxicity, this is done by using the special properties of the tumor microenvironment, such as pH value, glutathione concentration, and specific overexpressed enzymes; or by using exogenous stimulation, such as light, heat, and ultrasound. The nanotechnology, manipulating the matter within nanoscale, has high relevance to certain biological conditions, and has been widely utilized in cancer therapy. Together, the marriage of prodrug strategy which shield the side effects of parent drug and nanotechnology with pinpoint delivery capability has conceived highly camouflaged Trojan horse to maneuver cancerous threats.

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“…Another interesting strategy to solve the inconveniences of camptothecin and facilitate its oral administration would be its encapsulation in nanocarriers, including lipid-based nanoparticles ( Yang et al, 1999 ; Du et al, 2018 ), dendrimers ( Sadekar et al, 2013 ), and polymer nanoparticles ( Huarte et al, 2016 ; Ünal et al, 2020 ). In this context, an alternative to increase the oral absorption of this drug may be its encapsulation in nanoparticles capable of diffusing through the mucus layer and, then, of reaching the mucosal epithelium surface in order to increase their residence time in close contact with the absorptive membrane.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles from Gantrez-based conjugates for the oral delivery of camptothecin

Huarte

Espuelas

Martínez-Ohárriz

et al. 2021

International Journal of Pharmaceutics: X

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Redox sensitive lipid-camptothecin conjugate encapsulated solid lipid nanoparticles for oral delivery

Cited by 52 publications

References 36 publications

<p>Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review</p>

<p>Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review</p>

Nanoparticulation of Prodrug into Medicines for Cancer Therapy

Nanoparticles from Gantrez-based conjugates for the oral delivery of camptothecin

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