Redox regulation of the VEGF signaling path and tissue vascularization: Hydrogen peroxide, the common link between physical exercise and cutaneous wound healing

Aerobically Derived Lactate Stimulates Revascularization and Tissue Repair via Redox Mechanisms

“…invasion of macrophage-led tubes into the implant edge demonstrating development of blood vessels from pre-existing vessels. Instead there was more evidence of isolated endothelial cells and tubes in the Matrigel® substance, consistent with vasculogenesis (32). By day 11 of implantation, many tubules contained red blood cells suggesting that hematopoetic stem cells may have differentiated to form functional vessels.…”

Bronchopulmonary Dysplasia: The Role of Oxidative Stress

“…Indeed, the redox potential is a component of the Gibbs free energy equation that predicts the feasibility of a chemical reaction. Several biochemical pathways are dependent on the intracellular redox potential, including NF-B activation and HIF-1 levels as discussed earlier (Bonello et al, 2007;Chen & Shi, 2008;Land & Wilson, 2005;López-Lázaro, 2006;Roy et al, 2008). In the presence of a large peroxide load or sustained generation of peroxides, the formation of GSSG can exceed the capacity of glutathione reductase to recycle it into GSH, and the redox potential will change to a more oxidized state.…”

The Long-Term Effects of Colostrum Supplementation and Sprint-Endurance Training on Plasma VEGF Levels in Male Wistar Rats

“…7,11 For binding of VEGF, an optimal level of antioxidants must exist on the outer surface of the cell, since these antioxidants mediate the binding of VEGF to VEGFR-2. 5 However, it has been shown that binding of VEGF to VEGFR-2 activates NADPH oxidase and consequently produces oxidants necessary for angiogenic response to VEGF signaling. 9 Angiogenesis is a multistep process including migration and proliferation of endothelial cells and organization of cell masses as tube-like structures, interconnection of tube-like structures, and finally, maturity and stability of the forming vessel.…”

“…35 Moreover, athletes tend to use antioxidants to remove and scavenge free radicals which act as cellular mediators in the process of vascularization. 3,5 This can reduce vascularization in athletes taking antioxidant supplements. Even despite all the studies conducted on colostrum and accessibility to sports supplements enriched with colostrum, there are no studies on the interactive effects of colostrum supplementation and exercise training on VEGF in a controlled manner and in an experimental design (animal model).…”