Bronchopulmonary Dysplasia: The Role of Oxidative Stress

Lavoie, Jean-Claude; Mohamed, Ibrahim

doi:10.5772/30033

Cited by 1 publication

(2 citation statements)

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“…Both oxidants induce the oxidation of redox potential and increase the incidence of BPD [ 6 ]. Knowing that, in vivo, free oxygen will first be converted in superoxide anion before becoming hydrogen peroxide [ 7 ], a relevant question could be whether the addition of GSSG to PN will also be beneficial to infants exposed to O 2 supplementation. Brown et al showed that glutathione supplementation attenuated oxidative lung injury and protected preterm rabbits exposed to 95% O 2 [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

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Dose–Response Effects of Glutathione Supplement in Parenteral Nutrition on Pulmonary Oxidative Stress and Alveolarization in Newborn Guinea Pig

2022

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In premature infants, glutathione deficiency impairs the capacity to detoxify the peroxides resulting from O2 metabolism and those contaminating the parenteral nutrition (PN) leading to increased oxidative stress, which is a major contributor to bronchopulmonary dysplasia (BPD) development. In animals, the supplementation of PN with glutathione prevented the induction of pulmonary oxidative stress and hypoalveolarization (characteristic of BPD). Hypothesis: the dose of glutathione that corrects the plasma glutathione deficiency is sufficient to prevent oxidative stress and preserve pulmonary integrity. Three-day-old guinea pigs received a PN, supplemented or not with GSSG (up to 1300 µg/kg/d), the stable form of glutathione in PN. Animals with no handling other than being orally fed constituted the control group. After 4 days, lungs were removed to determine the GSH, GSSG, redox potential and the alveolarization index. Total plasma glutathione was quantified. The effective dose to improve pulmonary GSH and prevent the loss of alveoli was 330 µg/kg/d. A 750 µg/kg/d dose corrected the low-plasma glutathione, high-pulmonary GSSG and oxidized redox potential. Therefore, the results suggest that, in a clinical setting, the dose that improves low-plasma glutathione could be effective in preventing BPD development.

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Section: Discussionmentioning

confidence: 99%

“…Peroxides contaminating parenteral nutrition [ 1 , 2 , 3 , 4 , 5 ] are suspected to be a major trigger for the development of bronchopulmonary dysplasia (BPD) in extreme premature newborns [ 5 , 6 , 7 ]. This chronic lung disease affects 30–60% of premature infants born before 30 weeks of gestation [ 8 ].…”

Section: Introductionmentioning

confidence: 99%