Redox regulation in health and disease — Therapeutic potential of berberine

Siow, Yaw L.; Sarna, Lindsei K.; Karmin, O

doi:10.1016/j.foodres.2010.12.038

Cited by 63 publications

(39 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antioxidant properties of different varieties of B.vulgaris from various countries have been demonstrated [18]. Furthermore, B.vulgaris contains phenolic compounds with beneficial antioxidant activities that can prevent chronic diseases and cancers [5].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have demonstrated that antioxidants can reduce markers of oxidative stress in both experimental and clinical models of diabetes. The redox status is disrupted in both type 1 and type 2 DM due to hyperglycemia, resulting in stressmediated cellular injury [5]. Berberis vulgaris (B.vulgaris) Linn, which is commonly known as B.vulgaris, belongs to the family Berberidaceae.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of an ethanolic extract of Berberis vulgaris fruits on hyperglycemia and related gene expression in streptozotocin-induced diabetic rats

et al. 2016

View full text Add to dashboard Cite

Background: Finding a treatment for diabetes that does not have side effects has remained elusive. Among natural agents, much attention has been focused on phenolic compounds. For both their medicinal and nutritional value, barberry plants are of particular interest. Berberis vulgaris is known for its medicinal benefits in Iranian traditional medicine. In this study, we investigated the biological activities of B.vulgaris in a rodent model of experimentally induced diabetes. Method: The fasting blood glucose (FBG), insulin, malondialdehyde (MDA), and total antioxidant levels were measured in experimental groups of rats, including normoglycemic control, diabetic control, and diabetics treated with B.vulgaris, and the gene expression of the stress proteins HSF-1, HSP27, and HSP70 as well as the enzymes glucokinase (GK) and glucose 6-phosphatase (G6P) were assayed by real-time PCR.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of an ethanolic extract of Berberis vulgaris fruits on hyperglycemia and related gene expression in streptozotocin-induced diabetic rats

et al. 2016

View full text Add to dashboard Cite

show abstract

“…137 Berberine quenches superoxide anions and nitric oxide and 138 exerts radical scavenging activity against the high reactive 139 peroxynitrite and hydroxyl radicals [75]. In addition to its high 140 free radical scavenging effects, Berberine shows strong Fe 2+ 141 chelating activity [76].…”

mentioning

confidence: 99%

Berberine and neurodegeneration: A review of literature

Ahmed

Gilani

Abdollahi

et al. 2015

Pharmacological Reports

158

View full text Add to dashboard Cite

The excessive production of reactive oxygen species in nervous tissues is considered one of the major risk factors of neurodegenerative diseases. During the last two decades, much attention has been paid to the antioxidant and anti-inflammatory activity of natural products and compounds isolated from natural products which are often characterized by high efficacy and low adverse effects. Berberine is an isoquinoline alkaloid, widely present in different medicinal herbs, especially in the genus Berberis. It is mainly used as antidiarrhoeal, antibacterial, antifungal, and antiprotozoal agent. However, current research has focused on its beneficial role in neurodegenerative diseases, mainly due to its powerful antioxidant effect. The therapeutic potential of Berberine in different neurodegenerative diseases such as Alzheimer, Parkinson and Huntington disease has been brought to evidence by numerous studies. However, a limited number of reviews focus on the beneficial role of Berberine against neurodegeneration. The main objective of this review is to discuss the role of oxidative stress in neurodegeneration and the potential role of antioxidant compounds, in particular Berberine which is analyzed in its chemical structure, source, bioavailability, therapeutic potential, with special attention to its mechanism of action at a molecular level.

show abstract

“…Increasing evidences suggest that many phytochemicals can activate pathways that prevent or reverse oxidative injury. BBR is able to quench superoxide anions and exert radical scavenging activity [38]. In culture cells, BBR was able to inhibit ROS production and prevent generation of superoxide anions caused by NADPH oxidase in the LPS stimulated human monocyte-derived macrophages [39].…”

Section: Discussionmentioning

confidence: 99%

Berberine Protects against Hydrogen Peroxide-Induced Oxidative Damage in PC12 Cells through Activation of ERK1/2 Pathway

Liu¹,

Zeng²,

Gaur³

et al. 2017

Clin Exp Pharmacol

View full text Add to dashboard Cite

Oxidative stress is a much-recognized phenomenon linked with the progression of Neurodegenerative Diseases (NDs) due to imbalances in redox homeostasis. Increasing evidence indicates that excessive Reactive Oxygen Species (ROS), impairing the physiological functions of neurons via inducing cell apoptosis, is the main cause of NDs. The drug candidates are required that can effectively protect neurons from oxidative stress insult to slow down the process of neurodegenerative diseases. In present study, we investigated the protective effect and the underlying mechanisms of berberine (BBR, an isoquinoline alkaloid isolated from the herb Rhizoma coptidis, against oxidative damage in PC12 cells. It was found that BBR was able to suppress hydrogen peroxide (H 2 O 2 )-induced cell death in PC12 cells. Flow cytometry revealed that BBR significantly reduced the apoptosis of PC12 cells exposed to H 2 O 2 . Western blot analysis displayed that BBR stimulated the extracellular regulated ERK1/2 survival signaling, while application of PC12 cells with ERK1/2 pathway inhibitor PD98059 blocked the neuroprotective effect of BBR. These results together indicated that BBR is a potential protectant, and it protects PC12 cells against H 2 O 2 toxicity through activated the ERK1/2 pathway.

show abstract

Redox regulation in health and disease — Therapeutic potential of berberine

Cited by 63 publications

References 112 publications

Effects of an ethanolic extract of Berberis vulgaris fruits on hyperglycemia and related gene expression in streptozotocin-induced diabetic rats

Effects of an ethanolic extract of Berberis vulgaris fruits on hyperglycemia and related gene expression in streptozotocin-induced diabetic rats

Berberine and neurodegeneration: A review of literature

Berberine Protects against Hydrogen Peroxide-Induced Oxidative Damage in PC12 Cells through Activation of ERK1/2 Pathway

Contact Info

Product

Resources

About