Effects of an ethanolic extract of Berberis vulgaris fruits on hyperglycemia and related gene expression in streptozotocin-induced diabetic rats

Abstract

Background: Finding a treatment for diabetes that does not have side effects has remained elusive. Among natural agents, much attention has been focused on phenolic compounds. For both their medicinal and nutritional value, barberry plants are of particular interest. Berberis vulgaris is known for its medicinal benefits in Iranian traditional medicine. In this study, we investigated the biological activities of B.vulgaris in a rodent model of experimentally induced diabetes. Method: The fasting blood glucose (FBG), insulin, malondialdehyde (MDA), and total antioxidant levels were measured in experimental groups of rats, including normoglycemic control, diabetic control, and diabetics treated with B.vulgaris, and the gene expression of the stress proteins HSF-1, HSP27, and HSP70 as well as the enzymes glucokinase (GK) and glucose 6-phosphatase (G6P) were assayed by real-time PCR.

The effect of hydroalcoholic Berberis integerrima fruits extract on the lipid profile, antioxidant parameters and liver and kidney function tests in patients with nonalcoholic fatty liver disease

“…These results indicated that barberry can improve hyperglycemia in diabetic rats by inhibition of gluconeogenesis. ( Hemmati et al, 2017 ). These results were in agreement with our results…”

Anti-Diabetic Effects of Acankoreagenin from the Leaves of Acanthopanax Gracilistylus Herb in RIN-m5F Cells via Suppression of NF-κB Activation

“…Further investigations of the anti-diabetic effects of acankoreagenin are needed to be determined in diabetic rats in vivo [ 46 ].…”

Phytopharmacology and Clinical Updates of Berberis Species Against Diabetes and Other Metabolic Diseases

“…On the other hand, in diabetic rats, the beneficial effects of B. vulgaris extracts showed positive effects in attenuating the side effects of T2DM (Karami et al, 2016), ameliorating oxidative stress (Hemmati et al, 2016), decreasing the liver damage by influencing hepatic histopathological and biochemical markers (Rahimi-Madiseh et al, 2017), and showed that the serum cholesterol and serum triglycerides levels were decreased (Meliani et al, 2011).…”